DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BubR1 and Bub1

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	NP_001099977.1	Gene:	Bub1 / 296137	RGDID:	1311707	Length:	1059	Species:	Rattus norvegicus

Alignment Length:	1465	Identity:	319/1465 - (21%)
Similarity:	511/1465 - (34%)	Gaps:	500/1465 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KQMEEEVRTYKGADPLGAWYTFICWIEQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKL 105
            :..|..:::|||.||||.|.:|:.|:|:::|  .:...|.|:|...:.:|.|.:.|..|.|.|..
  Rat     9 RMFEAHMQSYKGNDPLGEWESFMKWVEENFP--DNKEHLVTILEHLMKEFLDKKNYHNDSRFISY 71

  Fly   106 FIKFMEKQKDKIEFYQQMYNNGIGTMLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDL 170
            .:||.|...|:.:|::.:|:.|:||..:..|::||...:..|..:.|..||:.|:..:|||:|.|
  Rat    72 CLKFAEYNSDRHQFFEFLYSQGVGTKSSYLYLSWAGHLEAQGEQQHASAIFQTGIHNQAEPMELL 136

  Fly   171 KEAHHHFGYTVGQRMLYSTGEEANAVNQELNERRLALQSLHGRRQQISNSI--TVGSIRT--GAA 231
            ::.:..|              :|......|.::....:.||.  .||.|.:  |..|..|  .|.
  Rat   137 QQQYRLF--------------QARLTGTHLPDQATTSEPLHS--AQILNQVMLTKSSPETENSAC 185

  Fly   232 VK-------SGLPGVVQVEPSTTTSRRNVGRNVEVFNDENSEGNIPISNSETEVKSSLRSIIDSA 289
            |.       ||      |.|||...:.|: |...|         |.||.||..|.||
  Rat   186 VPRSQGSECSG------VAPSTCDEKSNI-REQRV---------IMISKSECSVSSS-------- 226

  Fly   290 CSQENIKEPVAWNKANAKRHKHGKIFGSNASPDLGFDIHVDEQAMPPITNYERRLEQPFRFPTNF 354
                                                        |.|
  Rat   227 --------------------------------------------MAP------------------ 229

  Fly   355 VAKNRPQEPWVTPVTIEDEPNASGLPCYNKCLLYPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRN 419
                :|:...|             :.|..|.:   |.:.|||.||.||..:.:.:        ::
  Rat   230 ----KPEAQQV-------------MYCKEKLI---RGDSEFSFEELRAQKYNQRK--------KH 266

  Fly   420 DDWWGTGRVIRGIRCYPNFARYSKPQDLDELDKFWKPPLVPGLQVVFDKIYNEVEQKEYQPEELL 484
            :.|....|            .|.|.::.:..::          |::..|: :|:.:|.:|..||
  Rat   267 EQWVSEDR------------NYMKRKEANAFEE----------QLLKQKM-DELHKKLHQVVEL- 307

  Fly   485 AAKWMEKRNVTVHGDFDMEET------VCLPGNKMPRRKSFFPSSFRKSIMPRRVSSVQEEDEKK 543
                       .|.|....|.      ||:..|          :...:.:....:||:.::..:.
  Rat   308 -----------SHKDLPASENRPDANLVCVGQN----------TCSHQELRGLSLSSINQQTSEN 351

  Fly   544 EDEATLIVKDIPSQVAPKIPESPCDQIDEPKIKIFEDSGSPRDNFAVPAVPVPKIEIYEDSEEPQ 608
            ..|..|                     :||.:.:..:  :.......||:.:|.:.|
  Rat   352 SGEKPL---------------------EEPSVPLMVN--AVNSTLLFPAISLPSLPI-------- 385

  Fly   609 PTPKTRPFYDGDETCSTQMFNMFIKSQAVSTPKGTQKQAPSRQFGTVLKELPLPEEAAHSVESPV 673
                                           |...|.:..||.....::|.
  Rat   386 -------------------------------PVSGQSETDSRGVNQSIREF-------------- 405

  Fly   674 ETRSPTLRKQLSTILETSE-HGTQSLATSGTTTKSTITST-----SSPGSNAVSKLGSKIEENTP 732
            .|:|...:|:   :.||:: .......|:..|:...:..|     .||..:....||.
  Rat   406 MTQSGPDKKE---VCETNKVANINDFHTTPNTSLGMVQGTPCKVQPSPTVHTKEALGF------- 460

  Fly   733 GQMRLQRVISAGVSAVLSEPEKPG-GDNFLRRELW-----EPNAPSVPMLKSLRFQED----KTE 787
                        :..:...|..|. .|:   ::.|     ..:|......|:..|.||    |..
  Rat   461 ------------IMDMFQAPTLPDISDD---KDEWPSLDQNEDAFEAQFQKNAVFSEDWGVKKIM 510

  Fly   788 TIPRPLACFQEDKTET--LPQMPIALPENSMDHGSLGAENCFS----APQLPTLEDESDLCGL-F 845
            |:......|::...|.  ||| |...|..:...|......|.|    .|......|:|.:||: :
  Rat   511 TLSSAFPIFEDGNKENYGLPQ-PKNKPLGARTFGERSLSKCSSRSNEMPHTDEFMDDSTVCGIRY 574

  Fly   846 GKTPPKTNIFGSPKRNFDPTSQLFKSTQGDRRSFAVTGNKLEAAPSISNLQDSFMCDLSFVPETQ 910
            .||     :..|||...|.||                     ||...|.....|..|...:||.:
  Rat   575 NKT-----LAPSPKSIGDFTS---------------------AAQLSSTPFHKFPADPLQIPEDK 613

  Fly   911 PEAVAKSGAIQKFDIFLDDTQPKL---TKSKPVALMVSSFDLDCTLPETQQVAIKEPGTQQENIG 972
            ...|    |.|...:.||..:..:   :|.:.:.|:                        ||.|.
  Rat   614 ENVV----ATQYTHMALDSCKENMVDPSKDRKLGLI------------------------QEKIS 650

  Fly   973 HSHMIASFMKDCTEIGSCPSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVNENVGISKQPD 1037
            .|.             ||||| ||:                                .|:..| :
  Rat   651 ASL-------------SCPSQ-PAT--------------------------------GGLLTQ-E 668

  Fly  1038 EFFELNAATEMFATNISMIKNSTLLIPNAKVAEASELSIYYKTTPLTPKQSHRSWSQ--SDLETP 1100
            ..|.|..                                 ||.|     .:.|:..:  ||....
  Rat   669 AVFSLET---------------------------------YKCT-----GTDRAIMEDLSDASAG 695

  Fly  1101 PRENFVHPTSNGDQTVLNETLADANKNPFNVELISSLLESI-----DFSMYIE---KLPHCQLVG 1157
            .:..:|..:|.|:....|.|:    :||::.|||..||..:     .:|...|   |||
  Rat   696 LQVEWVQTSSFGNVNAPNFTI----ENPWDDELILKLLSGLSKPVTSYSNTFEWQSKLP------ 750

  Fly  1158 HVKRLHPNTHLEVHNEKFEVSKMIGKGAYGSVYVGKH--LKSGKKVALKQERPTNYWEFYICLEI 1220
               .:...|..::.:....|:.::|:||:..|:...|  .||.:|..||.::|.|.|||||.:::
  Rat   751 ---AIKTKTEFQLGSLLVYVNHLLGEGAFAQVFEAIHGDTKSKQKCILKVQKPANSWEFYIGMQL 812

  Fly  1221 HSRLTSE---QMIPSY-AHIDYALVGNNSSVYISEFSDYGSLIGVCNKVKSVTNRNMDEYVVMHL 1281
            ..||..|   ..|..| ||:     ..|.|:.:.|...||:|:.|.|..|:.:.:.|.:.:|:..
  Rat   813 MERLKPEVHHMFIKFYSAHL-----FQNGSILVGELYSYGTLLNVINLYKNTSEKVMPQALVITF 872

  Fly  1282 SCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNE---VSLQLIDFGVSIDMKLFPDNQTFN 1343
            :.:||.:|:.:|:..|||.|||||||:|........:|   ..|.|||.|.||||||||....|.
  Rat   873 AIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQDDEDLATGLTLIDLGQSIDMKLFPKGTVFT 937

  Fly  1344 YVHHDDLFKCIEMRTGRPWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPSTIWMPKTNVPRYFQRT 1408
            .......|:|.||.:.:||.||:|.||:.:.::.:|||.||:|  ::...:|.|:....|.....
  Rat   938 GKCETSGFQCPEMLSNKPWNYQVDYYGVAASIYCMLFGTYMKV--KNEGGVWKPEGLFRRLPHLD 1000

  Fly  1409 MWENIFRTLLNIRDCRTMPNLQQLRTQLKCALAEK 1443
            |||..|..:|||.||..:|:|..||.::...|.::
  Rat  1001 MWEEFFHIMLNIPDCHNLPSLDFLRQKMNKLLEQQ 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	38/117 (32%)
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883	100/279 (36%)
Bub1	NP_001099977.1	Mad3_BUB1_I	6..125	CDD:285506	38/117 (32%)
Bub1	NP_001099977.1	PKc_like	764..1047	CDD:304357	100/279 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335673
Domainoid	1	1.000	143	1.000	Domainoid score	I4531
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2808
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1411806at2759
OrthoFinder	1	1.000	-	-		FOG0004065
OrthoInspector	1	1.000	-	-		otm44728
orthoMCL	1	0.900	-	-		OOG6_103677
Panther	1	1.100	-	-	LDO	PTHR14030
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2819
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800