DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BubR1 and mad3

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	NP_588043.2	Gene:	mad3 / 2539219	PomBaseID:	SPCC1795.01c	Length:	310	Species:	Schizosaccharomyces pombe

Alignment Length:	341	Identity:	85/341 - (24%)
Similarity:	148/341 - (43%)	Gaps:	56/341 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MD-FDNAKENIQPLASGRNVSLLQASLSQDSTHGQELLAQRKQM--EEEVRTYKGA-DPLGAWYT 61
            || .:.:||||:|..:|.:.|.|..|.|::.|..:....|:::|  |.::.|.:.. |||..|..
pombe    13 MDVIEQSKENIEPRKAGHSASALAKSSSRNHTEKEVAGLQKERMGHERKIETSESLDDPLQVWID 77

  Fly    62 FICWIEQSYPAGGS-GSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYN 125
            :|.|...::|.|.: .|||.|:|.:|..:|..:..|:.|.|.::::::::....:.:|.:..:.:
pombe    78 YIKWTLDNFPQGETKTSGLVTLLERCTREFVRNPLYKDDVRYLRIWMQYVNYIDEPVELFSFLAH 142

  Fly   126 NGIGTMLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVGQRMLYSTG 190
            :.||...:.||..:|..::..|..:||||:::.|...:|:|....::.:..|.:...:....|..
pombe   143 HHIGQESSIFYEEYANYFESRGLFQKADEVYQKGKRMKAKPFLRFQQKYQQFTHRWLEFAPQSFS 207

  Fly   191 EEANAVNQ-ELNERRLALQSLHGRRQQISN---SITVGSIRTGAAVKSGLPGVVQVEPSTTTSRR 251
            ...|:||. :.......:|.:...|.:||.   ..:|.|...|:. |.|.||..|. ..|...||
pombe   208 SNTNSVNPLQTTFESTNIQEISQSRTKISKPKFKFSVYSDADGSG-KDGQPGTWQT-LGTVDQRR 270

  Fly   252 NVGRNVEVFNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVAWNKANAKRHKHGKIFG 316
                         .|.||                  ||.|....|.|:   |:..|....||
pombe   271 -------------KENNI------------------SATSWVGEKLPL---KSPRKLDPLGK--- 298

  Fly   317 SNASPDLGFDIHVDEQ 332
                    |.:|.||:
pombe   299 --------FQVHCDEE 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	33/124 (27%)
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883
mad3	NP_588043.2	Mad3_BUB1_I	52..176	CDD:214817	33/123 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	68	1.000	Domainoid score	I2723
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2052
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840