DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BubR1 and bub1

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	NP_588140.1	Gene:	bub1 / 2538736	PomBaseID:	SPCC1322.12c	Length:	1044	Species:	Schizosaccharomyces pombe

Alignment Length:	1510	Identity:	301/1510 - (19%)
Similarity:	472/1510 - (31%)	Gaps:	640/1510 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DPLGAWYTFICWIEQSYPAGGSGSGLQTVLHQCLTKFEDD-----ERYR---QDKR--LIKLF-I 107
            ||:..||..|.|:.::     ...|::||     .|..||     ||.|   .|.|  ||:|. |
pombe    48 DPVDVWYRCIEWLLET-----RFLGMETV-----NKMLDDAIQYLERCRFALNDVRHLLIQLAKI 102

  Fly   108 KFMEKQKDKI-----EFYQQMYNNGIGTMLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPL 167
            |...:..|::     :|| |:.:.|||..||.||..:..........::|.|:|...:...|.||
pombe   103 KQSYETPDELQQAAKQFY-QLASKGIGLELALFYEEYGSLLIRMQRWKEASEVFHAAVSREARPL 166

  Fly   168 EDLKEAHHHFGYTVGQRMLYSTGEEANAVNQELNERRLALQSLHGRRQQISNSITVGSIRTGAAV 232
                           .|:|.:..|.:.|.:            ||.....|.:          |..
pombe   167 ---------------VRLLRNAAEFSRAYD------------LHNAHPSIHD----------APY 194

  Fly   233 KSGLP------GVVQVEPSTTTSRRNVGRNVEVFNDENSEGNIPISNSETEVKSSLRSIIDSACS 291
            .|..|      |...|..||..|:   .::.:||:|.:|..:...::...:.||     ::|..:
pombe   195 SSPFPPPRIVLGSKPVSSSTLPSK---PKSFQVFSDASSSRDSQNASDLPQAKS-----LESEAN 251

  Fly   292 QENIKEPVAWNKANAKRHKHGKIFGSNASPDLGFDIHVDEQAMPPITNYERRLEQPFRFPTNFVA 356
            ..|:  |:.::|::.||.::...                                      ||:|
pombe   252 TPNL--PLLYDKSSGKRVEYSAF--------------------------------------NFLA 276

  Fly   357 KNRPQEPWVTPVTIEDEPNASGLPCYNKCLLYPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDD 421
                                          ||.... |.|.||.||..:|.
pombe   277 ------------------------------LYENGE-ERSMEECRAQRYLS-------------- 296

  Fly   422 WWGTGRVIRGIRCYPNFARYSKPQDLDELDKFWKPPLVPGLQVVFDKIYNEVEQKEYQPEELLAA 486
                       ...||.|.           .|  |.:||
pombe   297 -----------SIQPNTAA-----------SF--PKVVP-------------------------- 311

  Fly   487 KWMEKRNVTVHGDFDMEETVCLPGNKMPRRKSFFPSSFRKSIMPRRVSSVQEEDEKKEDEATLIV 551
                |..::||.|                       |...::.|...:.|.|:
pombe   312 ----KNEISVHHD-----------------------SSSSNVSPIYKNPVAEQ------------ 337

  Fly   552 KDIPSQVAPK----IPESPCDQIDEPKIKIFEDSGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPK 612
            .|.|::..||    :.:|     ..|::|:|:.        .:|....||    ...:.|.||..
pombe   338 SDTPTRSLPKNYAYVAKS-----TSPELKVFDT--------VMPVALSPK----PAQKPPSPTIH 385

  Fly   613 TR----PFYDGDETCSTQMFNMFIKSQAVSTPKGTQKQAPSRQFGTVLKELPLPEEAAHSVESPV 673
            |:    ...|        :||..::|:::.                            .|.:||:
pombe   386 TKAALADILD--------IFNQPLRSESLE----------------------------KSSKSPI 414

  Fly   674 ETRSPTLRKQLSTILETSEHGTQSLATSGTTTKSTITSTSSPGSNAVSKLGSKIEEN-------T 731
            ..:|    ..|.|.|:..|:.:.|.|||.|                    |...||:       |
pombe   415 SAQS----SYLGTPLKNDENSSNSGATSLT--------------------GRSQEEHLDFIPSLT 455

  Fly   732 PGQMRLQRVISAGVSAVLSEPEKPGGDNFLRRELWEPNAPSVPMLKSLRFQEDKTETIPRPLACF 796
            |.:               :.|.|          ::.||       |:|.|....:
pombe   456 PSK---------------NYPSK----------IYSPN-------KNLDFSHTAS---------- 478

  Fly   797 QEDKTETLPQMPIALPENSMDHGSLGAENCFSAPQLPTLEDESDLCGLFGKTPPKTNIFGSPKRN 861
               |.||.        :||.:..::..|..||.....||::|:       .|...:..|.:.||
pombe   479 ---KAETY--------KNSNELENVKREQPFSELLPSTLQEET-------ATGTTSTTFANAKR- 524

  Fly   862 FDPTSQLFKSTQGDRRSFAVTGNKLEAAPSISNLQDSFMCDLSFVPETQPEAVAKSGAIQKFDIF 926
                                                            :||           |..
pombe   525 ------------------------------------------------RPE-----------DSN 530

  Fly   927 LDDTQPKLTKSKPVALMVSSFDLDCTLPETQQVAIKEPGTQQENIGHSHMIASFMKDCTEIGSCP 991
            :..|.||...               |||.:.|.:..:
pombe   531 ISPTNPKKLH---------------TLPRSPQYSTVD---------------------------- 552

  Fly   992 SQMPASVVKTNISSTSNKIKFSNDSMSESSRKAP--VNENVGISKQPDEFFELNAATEMFATNIS 1054
                                 ||..:|.:..|..  ||||..:..:                  |
pombe   553 ---------------------SNSVLSPAMPKGYMFVNENQSMKHE------------------S 578

  Fly  1055 MIKNSTLLIP--NAKVAEASELS-IYYKTTPLTPKQSHRSWSQSDLETPPRENFVHPTSNGDQTV 1116
            .:.|....||  |.| .:..:|| |.:|  |..||........|...|.|.|..:...||....:
pombe   579 SVSNPVATIPHENGK-HDFGQLSPIEHK--PFFPKNDDELPGPSGYLTMPYEEAMASLSNLPTLI 640

  Fly  1117 --LNETLADANKNPFNVELISSLLESIDFSMYIEKLPHCQLVGHV---------------KRLHP 1164
              |:::|.|.   .|.| |..|||...|   |.|......||.|:               :|...
pombe   641 NPLDQSLRDL---LFQV-LRPSLLRDKD---YHEHETSFALVEHIESFVSKIKPKAGGPGRRRSS 698

  Fly  1165 NTHL----EVH-----NEKFEVSKMIGKGAYGSVYV---------------GKHLKSGKKVALKQ 1205
            |.|.    |.|     |....|...:|:||:..||:               |......|..|||.
pombe   699 NRHSLDGPEFHLFYPPNTNLSVISKLGQGAFAPVYLVKSKIETENGDVSQGGAENNESKLFALKI 763

  Fly  1206 ERPTNYWEFYICLEIHSRLTSEQMIPSYAHIDYALVGNNSSVYISEFSDYGSLIGVCNKVKSVT- 1269
            |.|.:.:|||:..:..:||...:...|...:....:.:::|..:.::...||::.:.|.:.:.|
pombe   764 ETPPSCFEFYLTRQAMTRLKGLRETNSILPVHQLHMFHDTSHLLMDYRPQGSILDLVNSMHNSTF 828

  Fly  1270 -NRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICAD--------PNEV----- 1320
             :..|||.:|:..|.:.|.|::.||...|||.|:|.||.||.....||        |..:
pombe   829 SSSGMDEILVVFFSIEFLRIIEALHTHKIIHGDLKADNALLRLETVADSEWSPIYSPEGLYGWSF 893

  Fly  1321 -SLQLIDFGVSIDMKLFPDNQTFNYVHHDDLFKCIEMRTGRPWTYQLDLYGLVSVMHVLLFGRY- 1383
             .:.|||||..||:.||.:...|......||..|||||.|||||||:|.:||.::::.:|||:|
pombe   894 KGIYLIDFGRGIDLSLFEEKVKFIADWDTDLQDCIEMREGRPWTYQIDYHGLAAIIYTMLFGQYI 958

  Fly  1384 ---MEVVQRSPSTIWMPKTNVPRYFQRTMWENIFRTLLNIRDCRTMPNLQQLRTQLKCALAEKEK 1445
               :||:......:...:  :.||:.:.:|..:|..|||       |.|.         ::|:..
pombe   959 ETRIEVINGQRRQVLTQR--MKRYWNQDLWHRLFDLLLN-------PTLH---------VSEENL 1005

  Fly  1446 YVAEAISKFNTILQK 1460
            .:.|.:||....:::
pombe  1006 PMTEELSKIRIEMEE 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	36/120 (30%)
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883	91/318 (29%)
bub1	NP_588140.1	Mad3_BUB1_I	30..158	CDD:214817	36/120 (30%)
bub1	NP_588140.1	STKc_Bub1_BubR1	718..1040	CDD:270883	91/321 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	116	1.000	Domainoid score	I1508
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I1177
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004065
OrthoInspector	1	1.000	-	-		otm47060
orthoMCL	1	0.900	-	-		OOG6_103677
Panther	1	1.100	-	-	LDO	PTHR14030
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2052
SonicParanoid	1	1.000	-	-		X2819
TreeFam	0	0.000	Not matched by this tool.
	10	9.980