Protein Alignment BubR1 and bub-1

DIOPT Version :10

• Sequence 1: NP_477382.1
• Gene: BubR1 / 35522
• FlyBaseID: FBgn0263855
• Length: 1460
• Species: Drosophila melanogaster
• Sequence 2: NP_492051.1
• Gene: bub-1 / 172468
• WormBaseID: WBGene00000275
• Length: 987
• Species: Caenorhabditis elegans
• Alignment Length: 897
• Identity: 191/897 - (21%)
• Similarity: 324/897 - (36%)
• Gaps: 240/897 - (26%)

  Fly   630 MFIKSQAVSTPKGTQKQAPSRQFGTVL------------KELPLPEEAAHSVESPV----ETRSP 678
            :|:|.|.:.|.:..:::..:| |...|            |.:...||....:.||:    :...|
 Worm   250 VFVKHQVIDTDRQAREEVENR-FNANLNPRRRHLSPVSEKTVDDEEEKRSRIYSPLVATKDAHRP 313

  Fly   679 TLRKQLSTILETSEHGTQSLATSGTTTKSTITSTSSPGSNA-------VSKLGSKIEENTPGQMR 736
            .||.::        ....:..|..:.|||......|...:|       :...|.| :.|.|.:
 Worm   314 ALRSKI--------ENPPATVTLSSDTKSASEKDVSDSDDADDDERLKIMTAGRK-DGNPPDR-- 367

  Fly   737 LQRVISAGVSAVLSEPEKPGGDNFLRRELWEPNAPSVPMLKSLRFQEDKTETIPRPLACFQEDKT 801
             ...||:..|...:...|.|....|..|           .|.|......::|:.     ...:||
 Worm   368 -STSISSNYSTASARTSKSGAGLDLMAE-----------NKCLEAHAMFSDTVH-----LASEKT 415

  Fly   802 ETLPQMPIALPENSMDHGSLGAENCFSAPQLPTLEDESDLCGLFGKTPPKTNIFGSPKRNFDPTS 866
            ..|....:.:||.|:           :..|:.|  |.|.||   ...|..|.....||:..:..:
 Worm   416 MVLGDDSVFVPERSL-----------ATTQIVT--DFSVLC---DPDPTMTITQERPKKVSNGLN 464

  Fly   867 QLFKSTQGDRRSFAVTGNKLEAAPSISNLQDSFMCDLSFVPETQPEAVAKSGAIQKFDIFLDDTQ 931
            .::     |..:......|:|.:                  |.|||.|..|
 Worm   465 VVY-----DEAAEPEESQKVEES------------------EVQPEIVLVS-------------- 492

  Fly   932 PKLTKSKPVALMVSSFDLDCTL----PETQQVAIKEP--GTQQENIGHSHMIASFMKDCTEIGSC 990
             .:|::.|..:....:|.:...    |.........|  |....||.      .:..:..|..:.
 Worm   493 -PVTQTSPATMFNDIYDDEIEFGFFKPSRGNFVTSTPAQGVHLVNID------EYFGNKEEESTH 550

  Fly   991 PSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVNENVGISKQPDEFFELNAATEMFATNI-- 1053
            ..:.|..|..|  |||.:|:.......:..:.:..|.|    |.:|:.....:::.:....|:
 Worm   551 EQEAPVFVAPT--SSTFSKLTRRKSLAANQAVQPSVTE----SSKPERSDPKDSSIDCLTANLGR 609

  Fly  1054 ----------SMIKNSTLLIPNAKVAEASELSIYYKTTPLTPKQSHRSWSQSDLETPPRENFVHP 1108
                      ::.:|:...|...|:...||:   .|...:.|      |
 Worm   610 RLSIGADEIPNLTENNESEITGCKIRRRSEI---IKQGDINP------W---------------- 649

  Fly  1109 TSNGDQTVLNETLADANKNPFNVELISSLLESIDFSMYIEKLPHCQLVGHVKRLHPNTHLEVHNE 1173
                |:| |.:.|....:.|.|:.         :|.   |:.|..|.:         ...||..|
 Worm   650 ----DET-LRKKLMCLVRPPQNMH---------EFQ---ERAPKIQAL---------RDCEVSGE 688

  Fly  1174 KFEVSKMIGKGAYGSVYVGKHLKSGKKVALKQERPTNYWEFYICLEIHSRLTSE----------- 1227
            |..:..:||:|.|..||... ....:.||:|.|.|:..||.|||.::.:||...
 Worm   689 KLHIQTLIGQGGYAKVYRAV-TDDQRTVAVKYEVPSCSWEVYICDQMRNRLKDRGLELMAKCCIM 752

  Fly  1228 QMIPSYAHIDYALVGNNSSVYISEFSDYGSLIGVCNKVKSVTNRNMDEYVVMHLSC----QMLDI 1288
            :::.:|.:       :.:|:.::::.:||:|:...|.:|...         .|::|    ||..:
 Worm   753 EVMDAYVY-------STASLLVNQYHEYGTLLEYANNMKDPN---------WHITCFLITQMARV 801

  Fly  1289 VDHLHAMGIIHADIKPDNFLLMKPI--------CADPNEVSLQLIDFGVSIDMKLFP-DNQTFNY 1344
            |..:||..|||.|||||||::.:.|        ....:...:::||:|.:|||  .| .||.|..
 Worm   802 VKEVHASKIIHGDIKPDNFMITRKIDDKWGKDALMSNDSFVIKIIDWGRAIDM--MPLKNQRFKG 864

  Fly  1345 VHHDDLFKCIEMRTGRPWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPSTIWMPKTNVPRYFQRTM 1409
            ....:.|.|.||..||.||||.|.:|..:.|.|::.|:|.::...|.....:......|...|..
 Worm   865 RAGTEAFDCPEMVDGRSWTYQADYFGFAATMAVVVAGKYAQLTGASVGDYSLNVDIKRRNILRDA 929

  Fly  1410 WENIFRTLLNIRDCRTMPNLQQLRTQLKCALAE--KEKYVA----EAISKFN 1455
            ..::....|||..|.::|:...|   :| :.:|  .||:.|    :|:||||
 Worm   930 CYDVINRFLNIPSCDSLPDWNIL---IK-SFSEIWNEKFEASGWRQAVSKFN 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:214817
		STKc_Bub1_BubR1	1174..1458	CDD:270883	89/312 (29%)
bub-1	NP_492051.1	STKc_Bub1_BubR1	689..980	CDD:270883	89/312 (29%)