DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BubR1 and san-1

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	NP_491846.2	Gene:	san-1 / 172342	WormBaseID:	WBGene00004721	Length:	390	Species:	Caenorhabditis elegans

Alignment Length:	444	Identity:	94/444 - (21%)
Similarity:	158/444 - (35%)	Gaps:	113/444 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDNAKENIQPLASGRNVSLLQASLSQDSTHGQELLAQRKQMEE--EVRTYKGADPLGAWYTFIC 64
            |:|...||::|...||.:..|:.::.:..|.....|...:.:||  .:...:.::.|.....|..
Worm    21 DWDRYSENVRPTRRGRKIDALKRNVEEVVTEETARLKLDQLLEELQNLECSEESEELQKILDFCS 85

  Fly    65 WIEQSYPAGGSGSGLQTVLHQCLTKFEDD----ERYRQDKRLIKLFIKFMEKQKDKI-----EFY 120
            |.|:..     ..|...|.::.|.|....    |:|::|:|::|::    ||..|..     :.|
Worm    86 WFEEKL-----AIGFHKVYYELLWKIISRHGFLEKYKEDERMLKIW----EKMADNSAGHAHDIY 141

  Fly   121 QQMYNNGIGTMLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVGQRM 185
            |...:.......|..|..|:.|.:|:|...:|..:..|.....|.|::.:.:|
Worm   142 QFAISRKSLVKCAALYARWSQSVELAGAYVEARRVLILARTNCAVPIQIVNDA------------ 194

  Fly   186 LYSTGEEANAVNQELNERRLALQSLHG--------RRQQISNSITVGSIRTGAAVKSGLPGVVQV 242
                 |:|    .|:.|.|..||....        .|:..:|...:|...|...|:  ||.:.
Worm   195 -----EDA----LEMREMRRHLQERDSDDDEEEEETRKAFTNLPVIGDNHTVPIVR--LPSMC-- 246

  Fly   243 EPSTTTSRR------NVGRNVEVFNDENSEGNIPISNSETEVKSSLRSI--IDSACSQENIKEPV 299
              |.||.:.      ||.|...|..|...:....:|.::.:....||::  :.:...:..|||..
Worm   247 --SDTTKKAMKFDTGNVERVNPVCKDNQMQPFEVLSYTDADDVEYLRNVHELHAHIERYAIKETT 309

  Fly   300 AWNKANAKRHKHGKIFGSNASPDLGFDIHVDEQAMPPITNYERRLEQPFRFPTNFVAKNRPQEPW 364
                       :..|.||:.|......|:       |:::.|                   .|.|
Worm   310 -----------NPSITGSSTSEAAAVTIY-------PVSSSE-------------------FEVW 337

  Fly   365 VTPVTIEDEPNASGLPCYNKCLLYPRPNIEFSPEEYRAYSFLKHRNPQHPFIHR 418
                |:|    .||.......:...|...:.|.|||.| |.|    |.||.:.|
Worm   338 ----TVE----GSGPTKAKARMAIKRVFKDLSFEEYAA-SLL----PNHPSMVR 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	27/131 (21%)
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883
san-1	NP_491846.2	Mad3_BUB1_I	80..180	CDD:384817	24/108 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14030
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910