DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BubR1 and Bub1b

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	NP_612549.1	Gene:	Bub1b / 171576	RGDID:	619791	Length:	1052	Species:	Rattus norvegicus

Alignment Length:	1492	Identity:	306/1492 - (20%)
Similarity:	493/1492 - (33%)	Gaps:	547/1492 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDNAKENIQPLASGRNVSLLQASLSQDSTHGQELLAQRK-QMEEEVRTYKGADPLGAWYTFICW 65
            :::.:|||:|||..||.::.||.:|:|..:.....|.|:| ..|.|:|.|.|.|||..|..:|.|
  Rat    14 EWELSKENVQPLRHGRIMATLQGALAQQESACSTTLQQQKWAFESEIRFYSGNDPLDVWDRYINW 78

  Fly    66 IEQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYNNGIGT 130
            .||:||.||..|.:.|:|.:.:...:.::||..|.|.:.|:||......:.::.|..:::.|||.
  Rat    79 TEQNYPQGGKESNMSTLLERAIEALQGEKRYYSDPRFLNLWIKLGHLCNEPLDMYSYLHSQGIGI 143

  Fly   131 MLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVGQRMLYSTGEEANA 195
            .||.|||:||..|:...|.:|||.:|:.|:||:||||:.|:..|..|...|.::.|.:.|.|...
  Rat   144 SLAQFYISWAEEYEARENFKKADIVFQQGIECKAEPLDRLQSQHRQFQARVSRQALLALGNEEEE 208

  Fly   196 VNQELNERRLALQSLHGRRQQISNS-ITVGSIRTGAAVKSGLPGVVQVEPSTTTSRRNVGRNVEV 259
            |......:|..|..|..|.::::.: |.    |.|.|:|:  ||..:...:|.....:..|.:.|
  Rat   209 VLGSSEPQRSTLAELKSRGKKMARAPIN----RVGGALKA--PGQSRGFLNTLPQPVHSNRRITV 267

  Fly   260 FNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVA--WNKANAKRHKHGKIFGSNASPD 322
            | |||:                     ||| |:..:.:|||  |......|.|
  Rat   268 F-DENA---------------------DSA-SRPELSKPVAQPWMAPPVPRAK------------ 297

  Fly   323 LGFDIHVDEQAMPPITNYERRLE-QPFRFPT----------NFV--AKNRPQEPWVTPVTIEDEP 374
                   :.:..|...|.:|.|| :|...|.          ||.  .:...|:..:||..||
  Rat   298 -------ENELQPGPWNTDRPLEYRPHSNPASVTSVPSVLPNFTPYVEESAQQTVMTPCKIE--- 352

  Fly   375 NASGLPCYNKCLLYPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDDWWGTGRVIRGIRCYPNFA 439
                 |..|..|...:|..|......|..|            |:..             |
  Rat   353 -----PSINHVLSTRKPGREEGDPLQRVQS------------HQQG-------------C----- 382

  Fly   440 RYSKPQDLDELDKFWKPPLVPGL-QVVFDKIYNEV---EQKEYQPEELLAAKWMEKRNVTVHGDF 500
                 ::..|...:.|..:..|: :..|::|..||   :.||.:..|||.:  .:||.
  Rat   383 -----EEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKERREAELLTS--AKKRE------- 433

  Fly   501 DMEETVCLPGNKMPRRKSFFPSSFRKSIMPRRVSSVQEEDEKKEDEATLIVKDIPSQVAPKIPES 565
            :|::.:    .:|.|:....     ::|...|....|||....:|.|.|.:.. .||....:|
  Rat   434 EMQKQI----EEMERKLKAM-----QTIQQERAGDQQEERMLSKDSARLEIAS-ESQEMSGVP-- 486

  Fly   566 PCDQIDEPKIKIFEDSGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPKTRPFYDGDETCSTQMFNM 630
                   |...|:..|.:||:  ..||..:.:       |:|:....:.||...||:.|.:.
  Rat   487 -------PSCSIWPLSSNPRE--ISPAENILQ-------EQPETKGPSMPFSIFDESLSDKK--- 532

  Fly   631 FIKSQAVSTPKGTQKQAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLRKQLSTILETSEHGT 695
             .||.|...|:....|                                  |:.| |:|:|:|
  Rat   533 -DKSPATDGPQVLNAQ----------------------------------RRPL-TVLKTTE--- 558

  Fly   696 QSLATSGTTTKSTITSTSSPGSNAVSKLGSKIEENTPGQMRLQRVISAGVSAVLSEPEKPGGDNF 760
                                                        ||.|.
  Rat   559 --------------------------------------------VIPAN---------------- 563

  Fly   761 LRRELWEPNAPSVPMLKSLRFQEDKTETIPRPLACFQEDKTETLPQMPIALPENSMDHGSLGAEN 825
                  |..:|.|                     |  ::.||..|     |.|:::..|......
  Rat   564 ------EDISPDV---------------------C--DELTEIEP-----LSEDAIITGFRNGIL 594

  Fly   826 CFSAPQLPTLEDESDL--CGLFGKTP-----PKTNIFGSPKRNFDPTSQLFKSTQGDRRSFAVTG 883
            |      |..||..|.  ...|..||     |..:|...||..........|:|:|..
  Rat   595 C------PNPEDTCDFARAARFASTPFHEILPSKSIASDPKEGLQEEDLDGKATEGHH------- 646

  Fly   884 NKLEAAPSISNLQDSFMCDLSFVPETQPEAVAKSGAIQKFDIFLDDTQPKLTKSKPVALMVSSFD 948
                    |.:||...:..||.:.|...||...||
  Rat   647 --------IVHLQTLSVKKLSPIIEDSREATHSSG------------------------------ 673

  Fly   949 LDCTLPETQQVAIKEPGTQQENIGHSHMIASFMKDCTEIGSCPSQMPASVVKTNISSTSNKIKFS 1013
                                                                           ||
  Rat   674 ---------------------------------------------------------------FS 675

  Fly  1014 NDSMSESSRKAPVNENVGISKQPDEFFELNAATEMFATNISMIKNSTLLIPNAKVAEASELSIYY 1078
            ..|.|                               .|:.|.||...:|.......:|:|.:|.
  Rat   676 RSSSS-------------------------------VTSTSSIKGFQILEKLELTTDAAENAIQ- 708

  Fly  1079 KTTPLTPKQSHRSWSQSDLETPPRENFVHPTSNGDQTVLNETLADANKNPFNVELISSLLE---S 1140
                 :|..||                                       :.::|:.||.|   .
  Rat   709 -----SPWCSH---------------------------------------YRLQLLKSLPELSAF 729

  Fly  1141 IDFSMYIEKLPHCQL-----VGHVKRLHPNTHLEVHNEKFEVSKMIGKGAYGSVYVGKHLKSGKK 1200
            .:||:....:|..:|     :||........||...:             |...:|... .|.:.
  Rat   730 AEFSVEDRPMPMLELGKEIELGHEDYCIKQEHLTCED-------------YRLFWVAPR-NSAEL 780

  Fly  1201 VALKQERPTNYWEFYICLEIHSRLTS--EQMIPSYAHIDYALVGNNSSVYISEFSDYGSLIGVCN 1263
            ..:|.......|:|||.|::..||..  :|:.....:.|..:|...   ||:           |:
  Rat   781 TMIKASSQPLPWDFYINLKLKERLNEDCDQLCSCCQYQDGHVVWYQ---YIN-----------CS 831

  Fly  1264 KVKSVTNRN--MDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADP------NEV 1320
            .::.:...:  :...:::.:.|.:|.||:.||...|:|.|:.|.:.:|...| .||      ::.
  Rat   832 TLQDLLQHSEFVTHEIIVLIICNLLTIVEKLHKAEIVHGDLSPRSLILRNRI-HDPYDYINKDDH 895

  Fly  1321 SLQLIDFGVSIDMKLFPDNQTFNYVHHDDLFKCIEMRTGR--------PWTYQLDLYGLVSVMHV 1377
            :::::||..|:||::..|  .|.|    ..|:..::..|:        |  ||:||.|:..:.|:
  Rat   896 AVRIVDFSYSVDMRVQLD--AFAY----SGFRTAQVLEGQKILANCSSP--YQVDLLGIADLAHL 952

  Fly  1378 LLFGRYMEVVQRSPSTIWMPKTNVPRYFQRTMWENIFRTLLNIRDCRTMPNLQQLRTQLKCA 1439
            |||..::.|..  ...:|....|........:|...|..:||..|..|:..|::|..::..|
  Rat   953 LLFKEHLHVFW--DGLLWRLSQNTSELKDGELWNKFFVQILNASDKSTVFILRELAAEMSGA 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	46/121 (38%)
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883	63/284 (22%)
Bub1b	NP_612549.1	Mad3_BUB1_I	51..172	CDD:285506	46/120 (38%)
Bub1b	NP_612549.1	PKc_like	739..1035	CDD:304357	69/313 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335671
Domainoid	1	1.000	105	1.000	Domainoid score	I6530
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1411806at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14030
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810