Protein Alignment BubR1 and Bub1b

DIOPT Version :9

• Sequence 1: NP_477382.1
• Gene: BubR1 / 35522
• FlyBaseID: FBgn0263855
• Length: 1460
• Species: Drosophila melanogaster
• Sequence 2: XP_006498685.1
• Gene: Bub1b / 12236
• MGIID: 1333889
• Length: 1053
• Species: Mus musculus
• Alignment Length: 1508
• Identity: 283/1508 - (18%)
• Similarity: 486/1508 - (32%)
• Gaps: 584/1508 - (38%)

  Fly     2 DFDNAKENIQPLASGRNVSLLQASLSQDSTHGQELLAQRKQ-MEEEVRTYKGADPLGAWYTFICW 65
            :::.:|||||||..||.:|.||.:|::..:.|...|.|:|: .|.|:|.|.|.|||..|..:|.|
Mouse    14 EWELSKENIQPLRHGRVMSTLQGALAKQESAGHTALQQQKRAFESEIRFYSGDDPLDVWDRYINW 78

  Fly    66 IEQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYNNGIGT 130
            .||:||.||..|.:..::.:.:...:.:.||..|.|.:.|:||......:.::.|..:.:.|||.
Mouse    79 TEQNYPQGGKESNMSALVERAIEALQGETRYYNDPRFLSLWIKLGHLCNEPLDMYSYLQSQGIGV 143

  Fly   131 MLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVGQRMLYSTGEEANA 195
            .||.|||:||..|:...|.:|||.||:.|:|.:||||:.|:..|..|...|.::...:.|.|...
Mouse   144 SLAQFYISWAEEYEARENFKKADIIFQEGIERKAEPLDRLQSQHRQFQSRVSRQAFLALGNEEEE 208

  Fly   196 VNQELNERRLALQSLHGRRQQISNS-ITVGSIRTGAAVKSGLPGVVQVEPSTTTSRRNVGRNVEV 259
            ..:....:|.:|..|..|.::::.: |:    |.|.|:|:  ||..:...:......:..|.:.|
Mouse   209 ALEPSEPQRSSLAELKSRGKKMARAPIS----RVGGALKA--PGQSRGFLNAVPQPVHGNRRITV 267

  Fly   260 FNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVA--WNKANAKRHKHGKIFGSNASPD 322
            | |||::                      ..|:..:.:|||  |
Mouse   268 F-DENAD----------------------TASRTELSKPVAQPW--------------------- 288

  Fly   323 LGFDIHVDEQAMPPITNYERRLEQPFRFPTNFVAKNRPQEPWVTPVTIEDEPNASGLPCYNKCLL 387
                      ..||:...:....||..:.|:..|..||.:   .|.::...|  |.||.:.
Mouse   289 ----------MAPPVPRAKENELQPGPWSTDRPAGRRPHD---NPASVTSIP--SVLPSFT---- 334

  Fly   388 YPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDDWWGTGRVIRGIRCYP--NFARYSKPQDLDEL 450
               |.:|.|.::                           .|:...:..|  |....::....:|.
Mouse   335 ---PYVEESAQQ---------------------------TVMTPCKIEPSINHVLSTRKPGREEG 369

  Fly   451 DKFWKPPLVPGLQVVFDKIYNEVEQKEYQPEELLAAKWMEKRNVTVHGDFDMEETVCLPGNKMPR 515
            |     ||        .::.:..:..|.:.|:::..|  ||....| |:|..||
Mouse   370 D-----PL--------QRVQSHQQGCEEKKEKMMYCK--EKIYAGV-GEFSFEE----------- 407

  Fly   516 RKSFFPSSFRKSIMPRRVSSVQEEDEKKEDEATLIVKDIPSQVAPKIPESPCDQIDEPKIKIFED 580
               .....|||.:..||.:.:....:|:|:
Mouse   408 ---IRAEVFRKKLKERREAELLTSAKKREE----------------------------------- 434

  Fly   581 SGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPKTRPFYDGDETCSTQMFNMFIKSQAVSTPKGTQK 645
                                                                          .||
Mouse   435 --------------------------------------------------------------MQK 437

  Fly   646 QAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLRKQLSTILETSEHGTQSLATSGTTTKSTIT 710
            |.               ||               :.::|..:....:.|..
Mouse   438 QI---------------EE---------------MERRLKAMQAVQQEGAG-------------- 458

  Fly   711 STSSPGSNAVSKLGSKIEENTPGQ--MRLQRVISAGVSAVLSEPEKPGGDNFLRRELWEPNAPSV 773
                         |.:.||..|.:  .|||         :.|.|::..|
Mouse   459 -------------GQQQEEKMPTEDPARLQ---------IASGPQEMSG---------------- 485

  Fly   774 PMLKSLRFQEDKTETIPRPLACFQEDKTETLPQMPIALPENSMDHGSLGAENCFSAPQLPTLEDE 838
                             .||:|
Mouse   486 -----------------VPLSC------------------------------------------- 490

  Fly   839 SDLCGLFGKTPPKTNIFGSPKRNFDPTSQLFKSTQGDRRSFAVTGNKLEAAPSISNLQDSFMCDL 903
             .:|.|                                     :.|..|.:|:.:.||:
Mouse   491 -SICPL-------------------------------------SSNPREISPAENILQE------ 511

  Fly   904 SFVPETQPEAVAKSGAIQKFDIFLDDTQPKLTKSKPVALMVSSFDLDCTLPETQQVAIKEPGTQQ 968
                  ||::   .|:...|.||.:....|..||                |.|       .|.|.
Mouse   512 ------QPDS---KGSSMPFSIFDESLSDKKDKS----------------PAT-------GGPQV 544

  Fly   969 ENIGHSHMIASFMKDCTEIGSCPSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVNE----- 1028
            .|                    ..:.|.||:||....|:|: ..|.|...|.:...|::|
Mouse   545 LN--------------------AQRRPLSVLKTTEVGTTNE-DVSPDICDELTELEPLSEDAIIT 588

  Fly  1029 ---NVGISKQPDEFFELNAATEMFATNISMIKNSTLLIP-----------NAKVAEA-----SEL 1074
               ||.:...|::..:...|..:.:|....|.:|..:..           :.|.|||     .:.
Mouse   589 GFRNVTLCPNPEDTCDFARAARLASTPFHEILSSKGIAADPEGLLQEEDLDGKAAEAHHTVHHQA 653

  Fly  1075 SIYYKTTPL---TPKQSHRS-WSQSDLETPPRENFVHPTSNGDQ-----TVLNETLADANKNP-- 1128
            .|..|.:|:   :.:.:|.| :|:|....|...:.     .|.|     .:.|:...||.::|
Mouse   654 LIIKKLSPIIEESREATHSSGFSRSSSSAPSTSSI-----KGFQLLEKLELTNDGAEDAIQSPWC 713

  Fly  1129 --FNVELISSLLESIDFSMY-IEKLPHCQLVGHVKRLHPNTHLEVHNEKFEVSKMIGKGAYGSVY 1190
              :.::|:.||||...|:.: :|..|...|                    |:.|.|..|....|.
Mouse   714 SQYRLQLLKSLLELSAFAEFSVEDRPMPVL--------------------EIGKEIELGPEDYVI 758

  Fly  1191 VGKHL-------------KSGKKVALKQERPTNYWEFYICLEIHSRLTSEQMIPSYAHIDYALVG 1242
            ..:||             .|.:...:|.......|:|||.|::..||..:     |..:......
Mouse   759 KQEHLTCDDYRLFWVAPRSSAELTMIKASSQPIPWDFYINLKLKERLNED-----YDQLCSCCQY 818

  Fly  1243 NNSSVYISEFSDYGSLIGVCNKVKSVTNRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNF 1307
            .:..|...::.:..:|..:....:.||:.     :::.:...:|.||:.||...|:|.|:.|.:.
Mouse   819 QDGHVVWYQYINCSTLQNLLQHSEFVTHE-----IIVLIIYNLLTIVEKLHRAEIVHGDLSPRSL 878

  Fly  1308 LLMKPICADP------NEVSLQLIDFGVSIDMKLFPDNQTFNYVHHDDLFKCIEMRTGR------ 1360
            :|...| .||      ::.:::::||..|:|:::..|  .|.|    ..|:..::..|:
Mouse   879 ILRNRI-HDPYDYVNKDDHAVRIMDFSYSVDLRVQLD--AFAY----SGFRTAQILEGQKILANC 936

  Fly  1361 --PWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPSTIWMPKTNVPRYFQRTMWENIFRTLLNIRDC 1423
              |  |.:||.|:..:.|:|||..::.|..  ...:|....:........:|...|..:||..|.
Mouse   937 SSP--YHVDLLGIADLAHLLLFKEHLHVFW--DGLLWKLSQSTSELKDSELWNKFFVRILNASDK 997

  Fly  1424 RTMPNLQQLRTQL 1436
            .|:..|.:|..::
Mouse   998 STVSVLGELAAEM 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	45/121 (37%)
		STKc_Bub1_BubR1	1174..1458	CDD:270883	62/290 (21%)
Bub1b	XP_006498685.1	Mad3_BUB1_I	51..172	CDD:369805	45/120 (38%)
		half-pint	<253..445	CDD:130706	56/441 (13%)
		PKc_like	740..1036	CDD:389743	63/312 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831997
Domainoid	1	1.000	102	1.000	Domainoid score	I6844
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6428
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2052
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780