DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BubR1 and bub1b

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	XP_031747062.1	Gene:	bub1b / 100125106	XenbaseID:	XB-GENE-1010857	Length:	1044	Species:	Xenopus tropicalis

Alignment Length:	1471	Identity:	303/1471 - (20%)
Similarity:	507/1471 - (34%)	Gaps:	528/1471 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDNAKENIQPLASGRNVSLLQASLSQDSTHGQELLAQRKQ-MEEEVRTYKGADPLGAWYTFICW 65
            :::.:|||:|||..||.:|.||..|||..:.....:.|:|| .|.|:|.|.|.|||..|..:|.|
Frog     7 EWELSKENVQPLRQGRVMSTLQEVLSQQESASHTAIQQQKQAFELELRFYSGDDPLDVWDRYIKW 71

  Fly    66 IEQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYNNGIGT 130
            .||::|.||..|.|..:|.:.:..|.:::||..|.|.:.:.:||.....:.::.|..:::..||.
Frog    72 AEQAFPQGGKESNLCPLLERAVKIFHEEQRYYDDLRYLSICLKFANFCSEPLDLYSYLHSQRIGV 136

  Fly   131 MLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVGQRMLYSTGEEANA 195
            ..|..||.||..::..||.:|||.||:.|::.:|||||.|:..|..|...|.:::|....|...|
Frog   137 SHALLYITWAEQFEARGNFKKADSIFQQGMQHKAEPLEKLEIHHRQFQARVSRQILQGISEGPEA 201

  Fly   196 VNQELNE-RRLALQSLHGRRQQISNSITVGSIRTGAAVKSGLPGV-VQVEPSTTTSRRNVGRNVE 258
            ...|:.| :|.:|..|..|.:   |.:.....|.|.::|....|: ||..|:.....|:   ...
Frog   202 EEPEVPEPQRSSLADLKSRGK---NKVKAPINRVGDSIKPRPHGLSVQAAPTQQIPSRS---RFA 260

  Fly   259 VFNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVAWNKANAKRHKHGKIFGSNASPDL 323
            || |||:....|...|.|..:.:..   ..|.|:||.::...||.....|:.|.....|.....|
Frog   261 VF-DENAASAAPELPSLTPQQWTAP---PPARSKENEQKAGQWNSGRPSRNSHQAAAASEPPQTL 321

  Fly   324 -GFDIHVDEQAMPPITNYERRLEQPFRFPTNFVAKNRPQEPWVTPVTIEDEPNASGLPCYNKCLL 387
             .|..:|||.|                           |:..|||..|.        |.....|.
Frog   322 PSFMPYVDESA---------------------------QQQTVTPCKIN--------PAVTSVLS 351

  Fly   388 YPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDDWWGTGRVIRGIRCYPNFARYSKPQDLDELDK 452
            ..:|..|..|.:                           ||            .:..|..:|...
Frog   352 SRKPGKEEDPLQ---------------------------RV------------QNNSQGKEEKVM 377

  Fly   453 FWKPPLVPGLQVVFDKIYNEVEQKEYQPEELLA----AKWMEKRNVTVHGDFDMEETVCLPGNKM 513
            :.|           ||:|..||  |:..||:.|    ||..:||      :.|::|.
Frog   378 YCK-----------DKVYAGVE--EFSLEEIRAEIYLAKIRKKR------EDDLQEI-------- 415

  Fly   514 PRRKSFFPSSFRKSIMPRRVSSVQEEDEKKEDEATLIVKDIPSQ-VAPKIPESPCDQIDEPKIKI 577
                     :.|:..|.|::..::::.:....|:..||.|.|.| |.|.|  :||:.
Frog   416 ---------ALRRQEMERQIQEMEKQLKGSCIESEEIVSDQPVQNVEPII--APCNS-------- 461

  Fly   578 FEDSGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPKTRPFYDGDETCSTQMFNMFIKSQAVSTPKG 642
                                                   ...:..|::|
Frog   462 ---------------------------------------NTNESLCASQ---------------- 471

  Fly   643 TQKQAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLRKQLSTILETSEHGTQSLATSGTTTKS 707
               |||..:|             .|..|  :...:||| .::.|:...:|.|
Frog   472 ---QAPVMEF-------------PHCFE--MADAAPTL-PRMETLPVFNETG------------- 504

  Fly   708 TITSTSSPGSNAVSKLGSKIEENTPGQMRLQRVISAGVSAVLSEPEKPGGDNFLRREL----WEP 768
                                                      ::|..||....|..:|    ::.
Frog   505 ------------------------------------------NKPSLPGLSPALSCDLPFTIFDE 527

  Fly   769 NAPSVPMLKSLRFQEDKTETIPRPLACFQEDKTETLPQMPIALPENSMDHGSLGAENCFSAPQLP 833
            :|.:.|   |:..|:.....:.||||        .:|:..:...|:.:.....|.|
Frog   528 SAEAAP---SMTDQKRMAAPVRRPLA--------AVPKSIVKSQESQLTDTLDGTE--------- 572

  Fly   834 TLEDESDLCGLFGKTPPKTNIFGSPKRNFDPTSQLFKSTQGDRRSFAVTGNKLEAAPSISNLQDS 898
            .|.:|:.:|| .||   ..::|..|:...|.......::....|:...:|..|::        ||
Frog   573 PLNEEAIVCG-SGK---NKSLFPDPEDTCDFVRAAHLASTPFHRARDQSGECLQS--------DS 625

  Fly   899 FMCDLSFVPETQPEAVAKSGAIQKFDIFLDDTQPKLTKSKPVALMVSSFDLDCTLPETQQVAIKE 963
            .  ||..:|                          |.:..||          |.....|::.||:
Frog   626 L--DLERLP--------------------------LREKTPV----------CEESYRQELCIKK 652

  Fly   964 PGTQQENIGHSHMIASFMKDCTEIGSCPSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVNE 1028
                     .|.::.:..:|               .:|::||.|:
Frog   653 ---------LSPILEASQED---------------TRTSVSSVSS-------------------- 673

  Fly  1029 NVGISKQPDEFFELNAATEMFATNISMIKNSTLLIPNAKVAEASELSIYYKTTPLTPKQSHRSWS 1093
                         :::.|.||.:.         .||. |:..|::::..|::.|.|.
Frog   674 -------------ISSTTSMFTSR---------PIPE-KLELATQITGVYESEPTTE-------- 707

  Fly  1094 QSDLETPPRENFVHPTSNGDQTVLNETLADANKNPFNVELISSLLESIDFSMYIEKLPH------ 1152
                |.|..|..                         .||...||||:...:...::.|
Frog   708 ----ELPQAEEL-------------------------AELHRQLLESLPELLVSPEIQHEVGTMP 743

  Fly  1153 -----------CQLVGHVKR---LHPNTHLEVHNEKFEVSKMIGKGAYGSVYVGKHLKSGKKVAL 1203
                       |:..| :|.   ||||:.|                 :....|...:...|..||
Frog   744 DMKEQGEVVLGCETYG-LKNEVILHPNSKL-----------------FMGAPVDWDMGDMKAFAL 790

  Fly  1204 KQERPTNYWEFYICLEIHSRLTS-------EQMIPSYAHIDYALVGNNS-SVY--ISEFSDYGSL 1258
            |.:.....|:||:.:::..||..       ||       .:..|..|.. |:|  |:.||....|
Frog   791 KVDYQPLPWDFYVTMQLKERLGDLFETFFIEQ-------TNCFLYQNGCISLYKDINRFSIQEIL 848

  Fly  1259 IGVCNKVKSVTNRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNEVSL- 1322
            :.....:|.         |::.::..:|.:|:.||::.|:|.|::|:..||...|....:.:.|
Frog   849 LDSEEHIKE---------VIVLVTYNLLSLVEKLHSVEIVHGDLRPETLLLDDKIFDLSSSLELK 904

  Fly  1323 ---QLIDFGVSIDMKLFPDNQTFNYVHHDDLFKCIEMRTGRPW------TYQLDLYGLVSVMHVL 1378
               :|:||..|:|:||:|...:...      |...:..:|:.:      .||:||.|:..::|::
Frog   905 GLFKLVDFSHSVDLKLYPIMSSLRG------FPIAQTESGQQFLSPQSSPYQVDLLGIADLVHLM 963

  Fly  1379 LFGRYMEVVQRSPSTIWMPKTNVPRYFQRTMWENIFRTLLN 1419
            :|.:.:::.|.  :::||....|||.....:|...|..:||
Frog   964 IFRKPLQLHQE--NSVWMICKEVPRLRGGNLWNKFFTKILN 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	44/121 (36%)
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883	61/266 (23%)
bub1b	XP_031747062.1	Mad3_BUB1_I	44..165	CDD:400553	44/120 (37%)
		MerR-DNA-bind	<390..431	CDD:401278	12/63 (19%)
		PKc_like	742..1044	CDD:419665	69/303 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7275
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1411806at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2052
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050