DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7881 and slc17a5

DIOPT Version :9

Sequence 1:	NP_001286144.1	Gene:	CG7881 / 35521	FlyBaseID:	FBgn0033048	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001070195.1	Gene:	slc17a5 / 767760	ZFINID:	ZDB-GENE-060929-1158	Length:	488	Species:	Danio rerio

Alignment Length:	467	Identity:	149/467 - (31%)
Similarity:	245/467 - (52%)	Gaps:	35/467 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DNEKGPVIG-IRHMQALLLFLAIVVNYTARLSVSVAIVAM---TDAATT--------NLDFPE-- 53
            |.:|.|..| .|:..|.|......|.|..|:::|||:|.|   :..|.|        |:..|:
Zfish    25 DIQKAPACGSSRYGLAFLSCYGFFVAYALRVNLSVAMVDMLKNSSKANTSSSICPPHNIPVPKHN 89

  Fly    54 -----YNWNGVQQSYILSSFYWGYIVTQFPAGFLVRRFGAKAVLLVPTLATAVLSGLTPYCVAWG 113
                 |:||...|.:||.||::|||:||.|.|:|.|::|||.:|.:..|.|.:.:.|||.....|
Zfish    90 HTAMVYDWNSETQGWILGSFFYGYIITQIPGGYLARKYGAKWLLGLGILCTVIFTLLTPLAADLG 154

  Fly   114 -GWQAFCTIRIVEGLFQGLIFPCIHEHLAKWSPPEDRNRLGAFAYSGADCGSVLAMASSGLIANG 177
             |:  ...:|::||:.:|:.:|.:|...|.|:||.:|:||...:|:||..|:|:|:..||.|. .
Zfish   155 AGY--LIAVRVLEGIGEGVTYPAMHAMWASWAPPLERSRLLTISYTGAQLGTVVALPLSGQIC-F 216

  Fly   178 SMGWPGIFYVSAGTCGLWCLLWVLFGANNAPSSRLIGSREREHIERSMKRQDGFHAQKIPIPWRA 242
            .:.|..:||:......||..||:.|.:|:..|.:.|...|:.:|..|:|.:  ....:..|||.:
Zfish   217 YLDWTYVFYIFGAVGLLWFFLWICFVSNSPSSHKRITEAEKTYIMSSLKNE--LSPTQDYIPWTS 279

  Fly   243 IWSSSPFYALLVVRSAQGWANSTMQLQTPSYMHGVLEMDIKSNALYSALPFLAMWGMSYVYLVFA 307
            |:.|.|.:|::|...:..|...|:....|:||:.||...|:.|.:.||||:|..|.::.:....|
Zfish   280 IFKSMPLWAIVVAHFSYNWTFYTLLTLLPTYMNDVLGFSIQQNGMLSALPYLGCWLLALLGGQLA 344

  Fly   308 DVAMSRQWMSLTTLRKSINTVSYWGPAAALIGIGFLDKSQTTLAIALMTINAGLNAGSGIGSILT 372
            |:...|.......:||:...|...|||..|:..|:.. ....||:|.:||::.|...|..|..:.
Zfish   345 DLLRERFLFRTVIVRKAFTVVGMAGPAVFLVAAGYTG-CNYILAVAFLTISSSLGGISASGFNIN 408

  Fly   373 IIDMSPNHSGMLMAIVNGIGNIFPLLTPLLVGVIV----TESDSRSQWQIVFAMTAVVFFIGNLV 433
            .:|::|:::|:|:.|.|....|     |.:||.::    |:|::..:|||||.::|.:...|.:.
Zfish   409 HLDIAPSYAGILLGITNSFATI-----PGMVGPVIARSLTKSNTIPEWQIVFYISAAINIFGAVF 468

  Fly   434 YLIWGTTDQQAW 445
            :.|:|....|.|
Zfish   469 FTIFGKGTVQPW 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7881	NP_001286144.1	2A0114euk	12..449	CDD:129972	145/457 (32%)
CG7881	NP_001286144.1	MFS	18..437	CDD:119392	139/441 (32%)
slc17a5	NP_001070195.1	2A0114euk	27..488	CDD:129972	148/465 (32%)
slc17a5	NP_001070195.1	MFS	92..472	CDD:119392	126/390 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D619250at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850