DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7881 and SLC17A5

DIOPT Version :9

Sequence 1:	NP_001286144.1	Gene:	CG7881 / 35521	FlyBaseID:	FBgn0033048	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	440	Identity:	136/440 - (30%)
Similarity:	224/440 - (50%)	Gaps:	40/440 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EKGPV-IGIRHMQALLLFLAIVVNYTARLSVSVAIVAMTDAATTNLD------FPE--------- 53
            |..|| ...|:..|:|.|....:.|..|:::|||:|.|.|:.||..|      .||
Human    30 EAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHH 94

  Fly    54 ------YNWNGVQQSYILSSFYWGYIVTQFPAGFLVRRFGAKAVLLVPTLATAVLSGLTPYCVAW 112
                  |.|:...|.:||.||::|||:||.|.|::..:.|.|.:|....|.||||:..||.....
Human    95 NQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADL 159

  Fly   113 G-GWQAFCTIRIVEGLFQGLIFPCIHEHLAKWSPPEDRNRLGAFAYSGADCGSVLAMASSGLIAN 176
            | |  ....:|.:|||.:|:.||.:|...:.|:||.:|::|.:.:|:||..|:|:::..||:|..
Human   160 GVG--PLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICY 222

  Fly   177 GSMGWPGIFYVSAGTCGL-WCLLWVLFGANNAPSSRLIGSREREHIERSMKRQDGFHAQKIPIPW 240
             .|.|..:||. .||.|: |.|||:...::.....:.|...|:|:|..|::.|  ..:|| .:||
Human   223 -YMNWTYVFYF-FGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQ--LSSQK-SVPW 282

  Fly   241 RAIWSSSPFYALLVVRSAQGWANSTMQLQTPSYMHGVLEMDIKSNALYSALPFLAMWGMSYVYLV 305
            ..|..|.|.:|::|...:..|...|:....|:||..:|..:::.|...|:||:|..|....:...
Human   283 VPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQ 347

  Fly   306 FADVAMSRQWMSLTTLRKSINTVSYWGPAAALIGIGFLDKSQTTLAIALMTINAGLNAGSGIGSI 370
            .||...::...|...:|:..:.:...|||..|:..||:. ...:||:|.:||:..|......|..
Human   348 AADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIG-CDYSLAVAFLTISTTLGGFCSSGFS 411

  Fly   371 LTIIDMSPNHSGMLMAIVNGIGNIFPLLTPLLVGVIVTES---DSRSQWQ 417
            :..:|::|:::|:|:.|.|....|     |.:||.::.:|   |:..||:
Human   412 INHLDIAPSYAGILLGITNTFATI-----PGMVGPVIAKSLTPDAGVQWR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7881	NP_001286144.1	2A0114euk	12..449	CDD:129972	133/432 (31%)
CG7881	NP_001286144.1	MFS	18..437	CDD:119392	131/426 (31%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	132/428 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D619250at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850