DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7881 and liz1

DIOPT Version :9

Sequence 1:	NP_001286144.1	Gene:	CG7881 / 35521	FlyBaseID:	FBgn0033048	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001342731.1	Gene:	liz1 / 2540342	PomBaseID:	SPBC2G2.01c	Length:	514	Species:	Schizosaccharomyces pombe

Alignment Length:	529	Identity:	107/529 - (20%)
Similarity:	190/529 - (35%)	Gaps:	120/529 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PVIGIRHMQALLLF-----------LAIVVNYTARLSVSVAIVA-MTDAATTNLDFPEYNWNGVQ 60
            |..|:..::..||.           ::..:||..|.|::.|.:: |.:         :...:|.:
pombe    13 PYYGLNKVEQKLLIKIDWFILSYCCVSYFINYLDRSSINNAYLSGMQE---------DLKMHGNE 68

  Fly    61 QSYILSSFYWGYIVTQFPAGFLVRRFGAKAVLLVPTLATAVLSGL-TPYCVAWGGWQAFCTIRIV 124
            ...|...|..|||:.|.|..:.::|..|:....|..    :|.|| |.:..|....:|...:|..
pombe    69 LQDINVVFTCGYIIGQLPGSYALQRVPARLWFSVMN----ILWGLMTIFSFAVHSVRALMILRFF 129

  Fly   125 EGLFQGLIFPCIHEHLAKW-SPPEDRNRLGAFAYSGADCGSVLA-----MASSGLIANGSM-GWP 182
            ..:.:...|...|..|..| ...|...|.|.|:.||. .|::.|     ...|.|...|.: ||.
pombe   130 MAVAEASTFAGTHYILGAWYKESELCKRAGIFSASGL-VGTMFAGYLQTAVHSSLNGKGGLSGWR 193

  Fly   183 GIFYVSAGTCGLWCLLWVLFGANNAPSSRLIGSREREHIERSMKRQDGFHAQKIPIPWRAI---- 243
            .:|.:. |...:...|:.||...:.|.:........:..|.|.||... ..:|.|:..:||
pombe   194 WLFIID-GILTIPLSLYGLFLFPDVPETTKAPYFTEQEKELSFKRLPA-RPKKKPLTLKAIKDIV 256

  Fly   244 -----------WSSSPFYALLVVRSAQG----WANSTMQLQTPSYMHGVLEMDIKSNALYSALPF 293
                       |..|.....:.|....|    |:|.....|..:|           ..:.:|:..
pombe   257 RSWRIYGLCILWIFSGETQAIAVNVLMGQWMKWSNKFSVAQINNY-----------PTVITAVGV 310

  Fly   294 LAMWGMSYVYLVFAD-VAMSRQW---MSLTTLRKSINTVSYWGPAAALIGIGFLDKSQTTLAIAL 354
            ::..|.|    |.:| :|.:.:|   :.|..    |.|||    |..|:.....|.::.....|.
pombe   311 VSTLGAS----VISDKLAGNPRWPFGLFLCV----ITTVS----ATILLAWNVPDGAKFFAYFAS 363

  Fly   355 MTINAGLNAGSGIGSILTIIDMSPNHSGMLMAIVNGIGNIF-----PLLTPL---------LVGV 405
            ....||........:  .|...:....|:::.::|...||:     |::.|.         |:|:
pombe   364 GCTYAGQAVWFSWAN--DICRDNDQERGVVVFLMNMCQNIWHIWWAPIMYPNTDTPRFIKGLIGL 426

  Fly   406 IVTESDSRSQWQIVFAMTAVVFFIGNLVYLIWGTTDQQ----AWDAEDYLQAKDPESESNAHQME 466
            :|...       |||..:.:|.::        ...|::    ..||:|:   .|..:|..:.:::
pombe   427 LVVGG-------IVFVSSCIVSYM--------QIRDKRIKRSIQDAKDF---DDVFTEHESLELK 473

  Fly   467 FKSRTDSEA 475
            ...:.|.|:
pombe   474 KIGKNDEES 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7881	NP_001286144.1	2A0114euk	12..449	CDD:129972	100/497 (20%)
CG7881	NP_001286144.1	MFS	18..437	CDD:119392	97/475 (20%)
liz1	NP_001342731.1	MFS_1	37..401	CDD:311564	84/404 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I1933
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.050