DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7881 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_001286144.1	Gene:	CG7881 / 35521	FlyBaseID:	FBgn0033048	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	464	Identity:	138/464 - (29%)
Similarity:	242/464 - (52%)	Gaps:	38/464 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RHMQALLLFLAIVVNYTARLSVSVAIVAMTDAATTNLD-FPE-----YNWNGVQQSYILSSFYWG 71
            |::.|::..|...:::..|.::.||||.|.:.:|..:| .||     :||:......|..||:||
Human    75 RYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWG 139

  Fly    72 YIVTQFPAGFLVRRFGAKAVLLVPTLATAVLSGLTPYC--VAWGGWQAFCT--IRIVEGLFQGLI 132
            ||:||.|.||:..:|.|..|.......|:.|:...|..  |.:|     |.  :||::||.:|:.
Human   140 YIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYG-----CVMCVRILQGLVEGVT 199

  Fly   133 FPCIHEHLAKWSPPEDRNRLGAFAYSGADCGSVLAMASSGLIANGSMGWPGIFYVSAGTCG-LWC 196
            :|..|...:||:||.:|:||...::.|:..|:|:||..:|::.. .:||..:||: .|..| :|.
Human   200 YPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQ-YIGWSSVFYI-YGMFGIIWY 262

  Fly   197 LLWVLFGANNAPSSR-LIGSREREHIERSMKRQDGFHA---QKIPIPWRAIWSSSPFYALLVVRS 257
            :.|:| .|...|::. .|.:.|:.:||.|:  .:|.:.   .|...||:..::|.|.||::|...
Human   263 MFWLL-QAYECPAAHPTISNEEKTYIETSI--GEGANVVSLSKFSTPWKRFFTSLPVYAIIVANF 324

  Fly   258 AQGWANSTMQLQTPSYMHGVLEMDIKSNALYSALPFLAMWGMSYVYLVFADVAMSRQWMSLTTLR 322
            .:.|....:.:..|:|...|....|....|.||:|.:.|..:..:....||...|||.::.|.:|
Human   325 CRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVR 389

  Fly   323 KSINTVSYWGPAAALIGIGFLDKSQTT-LAIALMTINAGLNAGSGIGSILTIIDMSPNHSGMLMA 386
            |.:|...:...|..|:.:||   |.|. :||:.:.:..|.:..:..|..:..:|::|.::.:||.
Human   390 KIMNCGGFGMEATLLLVVGF---SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMG 451

  Fly   387 IVNGIGNIFPLLTPLLVGVIVTESDSRSQWQIVFAMTAVVFFIGNLVYLIWGTTDQQAWDAEDYL 451
            |.||:|.:..::.||:||. :|...:|.:||.||.:.|:|.:.|.:.|.::.:.::|.|
Human   452 ISNGVGTLSGMVCPLIVGA-MTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEW------ 509

  Fly   452 QAKDPESES 460
              .|||:.|
Human   510 --ADPENLS 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7881	NP_001286144.1	2A0114euk	12..449	CDD:129972	134/451 (30%)
CG7881	NP_001286144.1	MFS	18..437	CDD:119392	130/434 (30%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	135/459 (29%)
		MFS	80..502	CDD:119392	130/435 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148607
Domainoid	1	1.000	49	1.000	Domainoid score	I11776
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740