DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7882 and SLC2A2

DIOPT Version :9

Sequence 1:	NP_610189.2	Gene:	CG7882 / 35520	FlyBaseID:	FBgn0033047	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_000331.1	Gene:	SLC2A2 / 6514	HGNCID:	11006	Length:	524	Species:	Homo sapiens

Alignment Length:	511	Identity:	149/511 - (29%)
Similarity:	244/511 - (47%)	Gaps:	75/511 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SLNWAAIGSSLGAAVPVGYCTGVMNSPAELMRS-------------------------------- 71
            :|.:..|.:.|| :...||..||:|:|.:::.|
Human     9 TLVFTVITAVLG-SFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISY 72

  Fly    72 --------WCNETLIASYDLNLSDAGLEILWSAIVSIFLVGGAIGSVVGATMANRFGRRGCFFIC 128
                    |..|..:|:..|      :.:|||..||.|.|||...|..|..:.:..||.....:.
Human    73 SMNPKPTPWAEEETVAAAQL------ITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVA 131

  Fly   129 GLLLGLGAI--SFYACRPLRSVELLLLGRMMVGLAGGLLTSFMSMWHSEISALSQRSTLAPLCPM 191
            .:|..:||:  .|....|  |..|::.||.:.||..||::..:.|:..||:..:.|..|.....:
Human   132 NILSLVGALLMGFSKLGP--SHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQL 194

  Fly   192 GLTLGVVIAQVCSLRSVLGGPENWHFGLAFYG-------LLVLVCYAPFRWYPESPKWLFIVQGR 249
            .:..|::|:|:..|..:||..:.||..|...|       ||:..|       ||||::|:|....
Human   195 AIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFC-------PESPRYLYIKLDE 252

  Fly   250 KEDARRQLQLLRGYTAGSAALKAEMEEMEQESACEVKTSSLMQVLRDPQLRLPLIIVCAFLGGQQ 314
            :..|::.|:.||||...:..:. ||.:..:|::.|.|. |::|:..:...|.|:::.......||
Human   253 EVKAKQSLKRLRGYDDVTKDIN-EMRKEREEASSEQKV-SIIQLFTNSSYRQPILVALMLHVAQQ 315

  Fly   315 LSGINAIFYYSVSIFRKAGLSSQASEWANLGAGSLNLFASMLGPVLLERVNRRPLMLF---STFF 376
            .||||.|||||.|||:.||:|...  :|.:|.|::|:..:.:...|:|:..||.|.|.   ..|.
Human   316 FSGINGIFYYSTSIFQTAGISKPV--YATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFV 378

  Fly   377 CAVFLLLFAIMLFFIESYSWFGMGCIGCIFLYIFFFQFGLGPMPFFIGAELFELATRPAAMSLGS 441
            ||:|:   ::.|..:..:||.....:..|||::.||:.|.||:|:|:.||.|....||||:::.:
Human   379 CAIFM---SVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAA 440

  Fly   442 LAYWLCNFIIGMAFPTMQNLWGALVFLPFSVTCLLIFGLTKRYLPETRGRHPSEVA 497
            .:.|.||||:.:.|..:.:..|..||..|:...|.....|...:|||:|:...|:|
Human   441 FSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIA 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7882	NP_610189.2	Sugar_tr	43..491	CDD:278511	145/499 (29%)
CG7882	NP_610189.2	MFS	95..480	CDD:119392	125/396 (32%)
SLC2A2	NP_000331.1	Sugar_tr	14..499	CDD:278511	148/506 (29%)
		MFS	98..485	CDD:119392	126/402 (31%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	314..320		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	0.197	Inparanoid score	I2535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.900