DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7882 and SLC2A1

DIOPT Version :9

Sequence 1:	NP_610189.2	Gene:	CG7882 / 35520	FlyBaseID:	FBgn0033047	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_006507.2	Gene:	SLC2A1 / 6513	HGNCID:	11005	Length:	492	Species:	Homo sapiens

Alignment Length:	466	Identity:	166/466 - (35%)
Similarity:	258/466 - (55%)	Gaps:	16/466 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 AIGSSLGAAVPVGYCTGVMNSPAELMRSWCNETLIASYDLNLSDAGLEILWSAIVSIFLVGGAIG 108
            |:|.::..::..||.|||:|:|.:::..:.|:|.:..|..::....|..|||..|:||.|||.||
Human    15 AVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIG 79

  Fly   109 SVVGATMANRFGRRGCFFICGLLLGLGAISFYACRPLRSVELLLLGRMMVGLAGGLLTSFMSMWH 173
            |.......||||||....:..||..:.|:.....:..:|.|:|:|||.::|:..||.|.|:.|:.
Human    80 SFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYV 144

  Fly   174 SEISALSQRSTLAPLCPMGLTLGVVIAQVCSLRSVLGGPENWH--FGLAFYGLLVLVCYAPFRWY 236
            .|:|..:.|..|..|..:|:.:|::||||..|.|::|..:.|.  ..:.|...|:.....||  .
Human   145 GEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPF--C 207

  Fly   237 PESPKWLFIVQGRKEDARRQLQLLRGYTAGSAALKAEMEEMEQES--ACEVKTSSLMQVLRDPQL 299
            ||||::|.|.:..:..|:..|:.||    |:|.:..:::||::||  ....|..:::::.|.|..
Human   208 PESPRFLLINRNEENRAKSVLKKLR----GTADVTHDLQEMKEESRQMMREKKVTILELFRSPAY 268

  Fly   300 RLPLIIVCAFLGGQQLSGINAIFYYSVSIFRKAGLSSQASEWANLGAGSLNLFASMLGPVLLERV 364
            |.|::|.......||||||||:||||.|||.|||:  |...:|.:|:|.:|...:::...::||.
Human   269 RQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGV--QQPVYATIGSGIVNTAFTVVSLFVVERA 331

  Fly   365 NRRPLMLFSTFFCAVFLLLFAIMLFFIESYSWFGMGCIGCIFLYIFFFQFGLGPMPFFIGAELFE 429
            .||.|.|......|...:|..|.|..:|...|.....|..||.::.||:.|.||:|:||.||||.
Human   332 GRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFS 396

  Fly   430 LATRPAAMSLGSLAYWLCNFIIGMAFPTMQNLWGALVFLPFSVTCLLIFGLTKRYLPETRGRHPS 494
            ...||||:::...:.|..|||:||.|..::.|.|..||:.|:|..:|.|..|...:|||:||...
Human   397 QGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFD 461

  Fly   495 EVAPLVALGFK 505
            |:|.    ||:
Human   462 EIAS----GFR 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7882	NP_610189.2	Sugar_tr	43..491	CDD:278511	160/450 (36%)
CG7882	NP_610189.2	MFS	95..480	CDD:119392	141/388 (36%)
SLC2A1	NP_006507.2	MFS_GLUT_Class1	14..458	CDD:340989	160/450 (36%)
		Monosaccharide binding. /evidence=ECO:0000269\|PubMed:24847886	282..288		5/5 (100%)
		Disordered. /evidence=ECO:0000305\|PubMed:30197081	468..492		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	0.197	Inparanoid score	I2535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.900