DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7882 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_610189.2	Gene:	CG7882 / 35520	FlyBaseID:	FBgn0033047	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_037011.2	Gene:	Slc2a2 / 25351	RGDID:	3705	Length:	522	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	153/497 - (30%)
Similarity:	246/497 - (49%)	Gaps:	61/497 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 AAIGSSLGAAVPVGYCTGVMNSPAELMRSWCNETL---------IASYDLNLSDAGL-------- 90
            |.:||     ...||..||:|:|.|::.|.....|         ..:||:|.:|..|
  Rat    17 AVLGS-----FQFGYDIGVINAPQEVIISHYRHVLGVPLDDRRATINYDINGTDTPLIVTPAHTT 76

  Fly    91 ---------------EILWSAIVSIFLVGGAIGSVVGATMANRFGRRGCFFICGLLLGLGAISFY 140
                           .:|||..||.|.|||.:.|..|..:.::.||.........|...||:...
  Rat    77 PDAWEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANSLSLTGALLMG 141

  Fly   141 ACRPLRSVELLLLGRMMVGLAGGLLTSFMSMWHSEISALSQRSTLAPLCPMGLTLGVVIAQVCSL 205
            ..:...:..|::.||.:.||..||::..:.|:..||:..:.|..|..|..:.|..|::|:|:..|
  Rat   142 CSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILISQIAGL 206

  Fly   206 RSVLGGPENWHFGLAFYG-------LLVLVCYAPFRWYPESPKWLFIVQGRKEDARRQLQLLRGY 263
            ..:||..:.||..|....       ||:|.|       ||||::|::....:..|::.|:.|||.
  Rat   207 SFILGNQDYWHILLGLSAVPALLQCLLLLFC-------PESPRYLYLKLEEEVRAKKSLKRLRGT 264

  Fly   264 TAGSAALKAEMEEMEQESACEVKTSSLMQVLRDPQLRLPLIIVCAFLGGQQLSGINAIFYYSVSI 328
            ...:..:. ||.:.::|::.|.|. |::|:..||..|.|:::.......||.||||.|||||.||
  Rat   265 EDVTKDIN-EMRKEKEEASTEQKV-SVIQLFTDPNYRQPIVVALMLHLAQQFSGINGIFYYSTSI 327

  Fly   329 FRKAGLSSQASEWANLGAGSLNLFASMLGPVLLERVNRRPLML---FSTFFCAVFLLLFAIMLFF 390
            |:.||:|...  :|.:|.|::|:..:.:..:|:|:..||.|.|   ...||||||:.|..::|
  Rat   328 FQTAGISQPV--YATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAVFMSLGLVLL-- 388

  Fly   391 IESYSWFGMGCIGCIFLYIFFFQFGLGPMPFFIGAELFELATRPAAMSLGSLAYWLCNFIIGMAF 455
             :.::|.....:..|||::.||:.|.||:|:|:.||.|....||.|::|.:.:.|:|||||.:.|
  Rat   389 -DKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFIIALCF 452

  Fly   456 PTMQNLWGALVFLPFSVTCLLIFGLTKRYLPETRGRHPSEVA 497
            ..:.:..|..||..|:...|:....|...:|||:|:...|:|
  Rat   453 QYIADFLGPYVFFLFAGVVLIFTLFTFFKVPETKGKSFDEIA 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7882	NP_610189.2	Sugar_tr	43..491	CDD:278511	150/489 (31%)
CG7882	NP_610189.2	MFS	95..480	CDD:119392	127/394 (32%)
Slc2a2	NP_037011.2	MFS_GLUT_Class1	12..488	CDD:340989	150/489 (31%)
Slc2a2	NP_037011.2	Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	312..318		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337945
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	0.113	Inparanoid score	I2429
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900