DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7882 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_610189.2	Gene:	CG7882 / 35520	FlyBaseID:	FBgn0033047	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	159/458 - (34%)
Similarity:	241/458 - (52%)	Gaps:	20/458 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 AIGSSLGAAVPVGYCTGVMNSPAELMRSWCNETLIASYDL----NLSDAGLEILWSAIVSIFLVG 104
            |:.|::..::..||..||:|:|.:::....|.|.:.....    ::....|..||:..|:||.||
  Rat    27 AVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSIPQGTLTTLWALSVAIFSVG 91

  Fly   105 GAIGSVVGATMANRFGRRGCFFICGLLLGLGAISFYACRPLRSVELLLLGRMMVGLAGGLLTSFM 169
            |.|.|.:...::...||:.......:|..||...........|.|:|:|||.::|...||.:..:
  Rat    92 GMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLV 156

  Fly   170 SMWHSEISALSQRSTLAPLCPMGLTLGVVIAQVCSLRSVLGGPENWHFGLAFYGLLVLVCYAPFR 234
            .|:..||:....|..|..|..:.:.:|:::|||..|.|:||....|...||...|..|:......
  Rat   157 PMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLAITVLPALLQLLLLP 221

  Fly   235 WYPESPKWLFIVQGRKEDARRQLQLLRGYTAGS---AALKAEMEEMEQESACEVKTSSLMQVLRD 296
            :.||||::|:|::..:..||:.|:.|.|:...|   |.||.|..::|:|     :..||:|:|..
  Rat   222 FCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKRKLERE-----RPLSLLQLLGS 281

  Fly   297 PQLRLPLIIVCAFLGGQQLSGINAIFYYSVSIFRKAGLSSQASEWANLGAGSLNLFASMLGPVLL 361
            ...|.||||.......||||||||:||||.|||..||:...|  :|.:|||.:|...:::..:|:
  Rat   282 RTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAGVEQPA--YATIGAGVVNTVFTLVSVLLV 344

  Fly   362 ERVNRRPLMLF---STFFCAVFLLLFAIMLFFIESYSWFGMGCIGCIFLYIFFFQFGLGPMPFFI 423
            ||..||.|.|.   ....||:.:.:..::|..:.|.|:..   |..||.::.||:.|.||:|:||
  Rat   345 ERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPSMSYVS---IVAIFGFVAFFEIGPGPIPWFI 406

  Fly   424 GAELFELATRPAAMSLGSLAYWLCNFIIGMAFPTMQNLWGALVFLPFSVTCLLIFGLTKRYLPET 488
            .||||....|||||::...:.|.||||:||.|..:.:..|..|||.|:|..|..|..|...:|||
  Rat   407 VAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLRVPET 471

  Fly   489 RGR 491
            |||
  Rat   472 RGR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7882	NP_610189.2	Sugar_tr	43..491	CDD:278511	157/456 (34%)
CG7882	NP_610189.2	MFS	95..480	CDD:119392	139/390 (36%)
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	159/458 (35%)
		MFS	78..447	CDD:119392	133/378 (35%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		5/5 (100%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	0.113	Inparanoid score	I2429
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900