Protein Alignment CG43366 and SERPINE3

DIOPT Version :10

• Sequence 1: NP_610188.2
• Gene: CG43366 / 35519
• FlyBaseID: FBgn0263109
• Length: 2140
• Species: Drosophila melanogaster
• Sequence 2: NP_001094790.1
• Gene: SERPINE3 / 647174
• HGNCID: 24774
• Length: 424
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 116/552 - (21%)
• Similarity: 183/552 - (33%)
• Gaps: 211/552 - (38%)

  Fly  1638 PPLLINLMASSTQSTRPPVKLDPSPESSQGLEASTAMMDED----LQSFARLCNELAFSYWRAIT 1698
            ||.||.|....:...|....|         .|..|.:..|.    .||.|...||..|
Human     2 PPFLITLFLFHSCCLRANGHL---------REGMTLLKTEFALHLYQSVAACRNETNF------- 50

  Fly  1699 SEKISSARSLVISPFALTSMLSMVFLGARGSTSGEMNEIL-------KLDDMVTFNPHLIFKNIT 1756
                      ||||..::..|.::..||.|||..::.:.|       ::.|.:    |.::..:.
Human    51 ----------VISPAGVSLPLEILQFGAEGSTGQQLADALGYTVHDKRVKDFL----HAVYATLP 101

  Fly  1757 NSVEQASDSDIATAAFVREIFSDRANGKILPFFKE-----KTQQLYAGHVEEVNFHVVNDIVRRR 1816
            .| .|.::.::|.:.||      :....:.|.|.|     ....|....:.|.|...:      :
Human   102 TS-SQGTEMELACSLFV------QVGTPLSPCFVEHVSWWANSSLEPADLSEPNSTAI------Q 153

  Fly  1817 TNLLVKRHTMGKVLEYLRTNSVWVNGP------------------LATISANLFQ-TDCSHGSTT 1862
            |:....|.|.|             .||                  |..:|...|| |.....|:|
Human   154 TSEGASRETAG-------------GGPSEGPGGWPWEQVSAAFAQLVLVSTMSFQGTWRKRFSST 205

  Fly  1863 DRDGEMFFQVHPTVRQRRLVPIPAVLYRSGFLAGYEPSLDATVVSFGRVQNTVSTVYVMPGHQ-- 1925
            |.      |:.|......||....:::::            |.|::|:.|:|.       |||
Human   206 DT------QILPFTCAYGLVLQVPMMHQT------------TEVNYGQFQDTA-------GHQVG 245

  Fly  1926 --------SSIS-----PMDN---LDRLERSLVETAFSDKQAWRRLLTSLMDRPGMEVQLPRFSH 1974
                    |::|     |.|.   |..:|..|..:..       .|.|:.:.|..|:|.||||..
Human   246 VLELPYLGSAVSLFLVLPRDKDTPLSHIEPHLTASTI-------HLWTTSLRRARMDVFLPRFRI 303

  Fly  1975 RSFVNASLGLQKMGLRGLFKSDFADLRGLTGAGNRDIFLSDMIQINTFSTCGEEKISEHHH---V 2036
            ::..|....|...|:..||....|:|:|::|   :|.|.                :||..|   :
Human   304 QNQFNLKSILNSWGVTDLFDPLKANLKGISG---QDGFY----------------VSEAIHKAKI 349

  Fly  2037 EMYPAPPLRKRNKDVDATDDDAFDSSERVVDFGSLVQESALGRGFYDDLLDPKYLELPLPLRPRQ 2101
            |:     |.:..|...||                     ||                   |..::
Human   350 EV-----LEEGTKASGAT---------------------AL-------------------LLLKR 369

  Fly  2102 ARVPDAPRLRFDKPFLYFVRHNPTGMILFMGR 2133
            :|:   |..:.|:||:||:|...||:.:|..|
Human   370 SRI---PIFKADRPFIYFLREPNTGITVFFDR 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43366	NP_610188.2	MDN1	956..>1505	CDD:444083
		Serpin	1687..2136	CDD:459662	103/499 (21%)
SERPINE3	NP_001094790.1	serpinE3	18..400	CDD:381040	110/536 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..174		8/49 (16%)