DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43366 and Serpina3c

DIOPT Version :9

Sequence 1:	NP_610188.2	Gene:	CG43366 / 35519	FlyBaseID:	FBgn0263109	Length:	2140	Species:	Drosophila melanogaster
Sequence 2:	NP_036789.2	Gene:	Serpina3c / 24794	RGDID:	2972	Length:	416	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	105/509 - (20%)
Similarity:	184/509 - (36%)	Gaps:	151/509 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1659 DPSPESSQGLEASTAMMDEDLQS--FARLCNELAFSYWRAITSEKISSARSLVISPFALTSMLSM 1721
            |..|...||       ....|.|  .|.:..:...|.::.:...  :..:::|.||.::::.|::
  Rat    27 DTLPHEDQG-------KGRQLHSLTLASINTDFTLSLYKKLALR--NPDKNVVFSPLSISAALAI 82

  Fly  1722 VFLGARGSTSGEMNEILK--LDDMVTFNPHLIFKNITNSVEQASD-SDIATAAFVREIFSDRANG 1783
            :.|||:.||..|:.|.||  |.::.....|..|.::...:.|..| ::|.|.:   .:|.|:..
  Rat    83 LSLGAKDSTMEEILEGLKFNLTEITEEEIHQGFGHLLQRLSQPEDQAEINTGS---ALFIDKEQ- 143

  Fly  1784 KILPFFKEKTQQLYAGHVEEVNFHVVNDIVRRRTNLLVKRHTMGKVLEYL-----RTNSVWVN-- 1841
            .||..|:|||:.||.......:|...|: .::..|..|...|.||:.|..     ||:.|.||
  Rat   144 PILSEFQEKTRALYQAEAFVADFKQCNE-AKKFINDYVSNQTQGKIAELFSDLDERTSMVLVNYL 207

  Fly  1842 ----------GPLATISANLFQTDCSHGSTTDRDGEMFFQVHPTVRQRRLVPIPAVLYRSGFLAG 1896
                      .|..|..:..:                       :.::|.|.:|.:..:. ....
  Rat   208 LFKGKWKVPFNPNDTFESEFY-----------------------LDEKRSVKVPMMKIKD-LTTP 248

  Fly  1897 Y--EPSLDATVVSFGRVQNTVSTVYVMPGH------QSSISPMDNLDRLERSLVETAFSDKQAWR 1953
            |  :..|..:|:.. :.....|.::::|..      :||:.|            ||.    :.|:
  Rat   249 YVRDEELSCSVLEL-KYTGNASALFILPDQGKMQQVESSLQP------------ETL----KKWK 296

  Fly  1954 RLLTSLMDRPGMEVQLPRFSHRSFVNASLGLQKMGLRGLFKSDFADLRGLTGAGNRDIFLSDMIQ 2018
               .||..|...|:::|:||..:..|....|.::|:|.:| |..|||..:||..|
  Rat   297 ---DSLRPRIISELRMPKFSISTDYNLEEVLPELGIRKIF-SQQADLSRITGTKN---------- 347

  Fly  2019 INTFSTCGEEKISEHHHVEMYPAPPLRKRNKDVDATDDDAFDSSERVVDFGSLVQESALGRGFYD 2083
                               ::.:..:.|...|||.|..:...::.......||.|
  Rat   348 -------------------LHVSQVVHKAVLDVDETGTEGAAATAVTAALKSLPQ---------- 383

  Fly  2084 DLLDPKYLELPLPLRPRQARVPDAPRLRFDKPFLYFVRHNPTGMILFMGRF-NP 2136
                                  ..|.|.|::||:..:..|....:.|||:. ||
  Rat   384 ----------------------TVPLLNFNRPFMLVITDNNGQSVFFMGKVTNP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43366	NP_610188.2	SERPIN	1687..2136	CDD:294093	96/477 (20%)
Serpina3c	NP_036789.2	SERPIN	54..415	CDD:214513	96/473 (20%)
Serpina3c	NP_036789.2	RCL	365..392		6/58 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100