DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43366 and Serpina1

DIOPT Version :9

Sequence 1:	NP_610188.2	Gene:	CG43366 / 35519	FlyBaseID:	FBgn0263109	Length:	2140	Species:	Drosophila melanogaster
Sequence 2:	NP_071964.2	Gene:	Serpina1 / 24648	RGDID:	3326	Length:	411	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	103/509 - (20%)
Similarity:	195/509 - (38%)	Gaps:	154/509 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1658 LDPSPESSQGLEASTAMMDEDLQSFARLCNEL---AFSYWRAITSEKISSARSLVISPFALTSML 1719
            |.||..:....|..|:..|:. .::.::.:.|   |||.:|.:..:  |:..::..||.::|:..
  Rat    18 LAPSFLAEDAQETDTSQQDQS-PTYRKISSNLADFAFSLYRELVHQ--SNTSNIFFSPMSITTAF 79

  Fly  1720 SMVFLGARGSTSGEMNEILK--LDDMVTFNPHLIFKNITNSVEQASDSDI----ATAAFVREIFS 1778
            :|:.||::|.|..::.|.|:  |..:...:.|..|.::..::.: .||::    ....||.:
  Rat    80 AMLSLGSKGDTRKQILEGLEFNLTQIPEADIHKAFHHLLQTLNR-PDSELQLNTGNGLFVNK--- 140

  Fly  1779 DRANGKILPFFKEKTQQLYAGHVEEVNF-------HVVNDIVRRRTNLLVKRHTMGKVLEYLR-- 1834
               |.|::..|.|:.:..|......|||       .|:||        .|::.|.||:::.::
  Rat   141 ---NLKLVEKFLEEVKNNYHSEAFSVNFADSEEAKKVIND--------YVEKGTQGKIVDLMKQL 194

  Fly  1835 --------TNSVWVNG-------PLATISANLFQTDCSHGSTTDRDGEMFFQVHPTVRQRRLVPI 1884
                    .|.::..|       |..|..|: |..|   .|||                   |.:
  Rat   195 DEDTVFALVNYIFFKGKWKRPFNPEHTRDAD-FHVD---KSTT-------------------VKV 236

  Fly  1885 PAVLYRSGFLAGYEPSLDATVVSFGRVQNTVSTVYVMPGHQSSISPMDNLDRLERSLVETAFSDK 1949
            |.:.....|...|..:|.:.|:....:.| .:.::::|..       ..:..||::|.:...|
  Rat   237 PMMNRLGMFDMHYCSTLSSWVLMMDYLGN-ATAIFLLPDD-------GKMQHLEQTLTKDLIS-- 291

  Fly  1950 QAWRRLLTSLMDRPGMEVQLPRFSHRSFVNASLGLQKMGLRGLFKSDFADLRGLTGAGNRDIFLS 2014
                |.|.:...|..: :..|:.|.....|....|..:|:..:|.:| |||.|:|    .|..|
  Rat   292 ----RFLLNRQTRSAI-LYFPKLSISGTYNLKTLLSSLGITRVFNND-ADLSGIT----EDAPL- 345

  Fly  2015 DMIQINTFSTCGEEKISEHHHVEMYPAPPLRKRNKDVDATDDDAFDSSERVVDFGSLVQESALGR 2079
                          |:|:..|             |.|...|:...:::      |:.|.|:
  Rat   346 --------------KLSQAVH-------------KAVLTLDERGTEAA------GATVVEA---- 373

  Fly  2080 GFYDDLLDPKYLELPLPLRPRQARVPDAPRLRFDKPFLYFVRHNPTGMILFMGR 2133
                         :|:.|         .|:::||.||::.:..:.|...||:|:
  Rat   374 -------------VPMSL---------PPQVKFDHPFIFMIVESETQSPLFVGK 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43366	NP_610188.2	SERPIN	1687..2136	CDD:294093	97/480 (20%)
Serpina1	NP_071964.2	alpha-1-antitrypsin_like	49..406	CDD:239011	96/477 (20%)
Serpina1	NP_071964.2	RCL	367..386		7/44 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100