DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43366 and Serpina1d

DIOPT Version :9

Sequence 1:	NP_610188.2	Gene:	CG43366 / 35519	FlyBaseID:	FBgn0263109	Length:	2140	Species:	Drosophila melanogaster
Sequence 2:	NP_033272.1	Gene:	Serpina1d / 20703	MGIID:	891968	Length:	413	Species:	Mus musculus

Alignment Length:	517	Identity:	102/517 - (19%)
Similarity:	190/517 - (36%)	Gaps:	151/517 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1640 LLINLMASSTQSTRPPVKLDPSPESSQGLEASTAMMDEDLQSFARLCNELAFSYWRAITSEKISS 1704
            |:.:.:|...|.|....| |.||.|.   |.:|.:.|..|:.:..|.::              |:
Mouse    18 LVPSFLAEDVQETDTSQK-DQSPASH---EIATNLGDFALRLYRELVHQ--------------SN 64

  Fly  1705 ARSLVISPFALTSMLSMVFLGARGSTSGEMNEILKLDDMVTFNP--HLIFKNITNSVEQASDSDI 1767
            ..::..||.::.:..:|:.||::|.|..::.|.|:.:...|...  |..|:::..::.: .||::
Mouse    65 TSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNR-PDSEL 128

  Fly  1768 ATAAFVREIFSDRANG-------KILPFFKEKTQQLYAGHVEEVNF-------HVVNDIVRRRTN 1818
            ..:.         .||       |::..|.|:.:..|...|..|||       .|:||
Mouse   129 QLST---------GNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVIND------- 177

  Fly  1819 LLVKRHTMGKVLEYLR---TNSVWVNGPLATISANLFQTDCSHGSTTDRDGEMFFQVHPTVRQRR 1880
             .|::.|.||::|.::   .::|:     |..:..||:.........:...|..|.|.    :..
Mouse   178 -FVEKGTQGKIVEAVKKLDQDTVF-----ALANYILFKGKWKQPFDPENTEEAEFHVD----EST 232

  Fly  1881 LVPIPAVLYRSGFLAGYEPSLDATVVSFGRVQNTVSTVYVMPGHQSSISPMDNLDRLERSLVETA 1945
            .|.:| ::..||.|..:..|:.::.|.........:.|:::|..       ..:..||::|.:..
Mouse   233 TVKVP-MMTLSGMLDVHHCSMLSSWVLLMDYAGNTTAVFLLPDD-------GKMQHLEQTLNKEL 289

  Fly  1946 FSDKQAWRRLLTSLMDRPGMEVQLPRFSHRSFVNASLGLQKMGLRGLFKSDFADLRGLTGAGNRD 2010
            .|.....||       |...::.:||.|.....|....:..:|:..:|.:. |||.|:|
Mouse   290 ISQFLLNRR-------RSDAQIHIPRLSISGNYNLKTLMSPLGITRIFNNG-ADLSGIT------ 340

  Fly  2011 IFLSDMIQINTFSTCGEE----KISEHHHVEMYPAPPLRKRNKDVDATDDDAFDSSERVVDFGSL 2071
                            ||    |:|:..|          |....:|.|..:|..::
Mouse   341 ----------------EENAPLKLSKAVH----------KAVLTIDETGTEAAAAT--------- 370

  Fly  2072 VQESALGRGFYDDLLDPKYLELPLPLRPRQARVPDAPRLRFDKPFLYFVRHNPTGMILFMGR 2133
                         :|......:|             |.:|||.|||:.:....|...:|:|:
Mouse   371 -------------VLQVATYSMP-------------PIVRFDHPFLFIIFEEHTQSPIFVGK 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43366	NP_610188.2	SERPIN	1687..2136	CDD:294093	88/470 (19%)
Serpina1d	NP_033272.1	SERPIN	53..410	CDD:214513	90/478 (19%)
Serpina1d	NP_033272.1	RCL	368..387		5/53 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100