DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43366 and Serpina1b

DIOPT Version :9

Sequence 1:	NP_610188.2	Gene:	CG43366 / 35519	FlyBaseID:	FBgn0263109	Length:	2140	Species:	Drosophila melanogaster
Sequence 2:	NP_033270.3	Gene:	Serpina1b / 20701	MGIID:	891970	Length:	413	Species:	Mus musculus

Alignment Length:	515	Identity:	103/515 - (20%)
Similarity:	194/515 - (37%)	Gaps:	153/515 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1643 NLMASSTQSTRPPVKLDPSPESSQGLEASTAMMDEDLQSFARLCNELAFSYWRAITSEKISSARS 1707
            :.:|...|.|....| |.||.|.   |.:|.:.|            .|.|.:|.:..:  |:..:
Mouse    21 SFLAEDVQETDTSQK-DQSPASH---EIATNLGD------------FAISLYRELVHQ--SNTSN 67

  Fly  1708 LVISPFALTSMLSMVFLGARGSTSGEMNEILKLDDMVTFNP--HLIFKNITNSVEQASDSDIATA 1770
            :..||.::.:..:|:.||::|.|..::.|.|:.:...|...  |..|:::..::.: .||::..:
Mouse    68 IFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNR-PDSELQLS 131

  Fly  1771 AFVREIFSDRANG-------KILPFFKEKTQQLYAGHVEEVNF-------HVVNDIVRRRTNLLV 1821
            .         .||       |::..|.|:.:..|...|..|||       .|:||        .|
Mouse   132 T---------GNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVIND--------FV 179

  Fly  1822 KRHTMGKVLEYLR---TNSVWVNGPLATISANLFQTDCSHGSTTDRDGEMFFQVHPTVRQRRLVP 1883
            ::.|.||::|.::   .::|:     |..:..||:.........:...|..|.|..:.    .|.
Mouse   180 EKGTQGKIVEAVKELDQDTVF-----ALANYILFKGKWKKPFDPENTEEAEFHVDKST----TVK 235

  Fly  1884 IPAVLYRSGFLAGYEPSLDATVVSFGRVQNTVSTVYVMPGHQSSISPMDNLDR-LERSLVETAFS 1947
            :|.::. ||.|..:..|:.::.|.........|.|:::|    ....|.:|:: |.:.|:.....
Mouse   236 VPMMML-SGMLDVHHCSILSSWVLLMDYAGNASAVFLLP----EDGKMQHLEQTLNKELISKILL 295

  Fly  1948 DKQAWRRLLTSLMDRPGMEVQLPRFSHRSFVNASLGLQKMGLRGLFKSDFADLRGLTGAGNRDIF 2012
            :::  |||         :::.:||.|.....|....:..:|:..:|.:. |||.|:|
Mouse   296 NRR--RRL---------VQIHIPRLSISGDYNLKTLMSPLGITRIFNNG-ADLSGIT-------- 340

  Fly  2013 LSDMIQINTFSTCGEE----KISEHHHVEMYPAPPLRKRNKDVDATDDDAFDSSERVVDFGSLVQ 2073
                          ||    |:|:..|             |.|...|:...:::...|
Mouse   341 --------------EENAPLKLSKAVH-------------KAVLTIDETGTEAAAATV------- 371

  Fly  2074 ESALGRGFYDDLLDPKYLELPLPLRPRQARVPDAPRLRFDKPFLYFVRHNPTGMILFMGR 2133
                            :..:|:.:         .|.||||.|||:.:....|...:|:|:
Mouse   372 ----------------FEAVPMSM---------PPILRFDHPFLFIIFEEHTQSPIFVGK 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43366	NP_610188.2	SERPIN	1687..2136	CDD:294093	92/471 (20%)
Serpina1b	NP_033270.3	SERPIN	53..410	CDD:214513	91/467 (19%)
Serpina1b	NP_033270.3	RCL	368..387		6/50 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100