DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT41F and SLC30A2

DIOPT Version :9

Sequence 1:	NP_610185.1	Gene:	ZnT41F / 35513	FlyBaseID:	FBgn0025693	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001004434.1	Gene:	SLC30A2 / 7780	HGNCID:	11013	Length:	372	Species:	Homo sapiens

Alignment Length:	388	Identity:	129/388 - (33%)
Similarity:	205/388 - (52%)	Gaps:	81/388 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 CNHQPGFRANSKSKSAQEAKYKIMLAVALCCVFMIIEFLGGYVAGSLAIMTDAAHLASDCISFVI 175
            |:.|.|..::...|.. :|:.::.:|.|:|.:|||.|.:|||:|.|||:|||||||.:|..|.:|
Human    53 CHAQKGPDSHCDPKKG-KAQRQLYVASAICLLFMIGEVVGGYLAHSLAVMTDAAHLLTDFASMLI 116

  Fly   176 GLVAIWIGGRPPDERMSFGYKRFEVIGALASILGIWFVTTLLVVVAIERIFSQDFELNADMMMLI 240
            .|.::|:..||..:.|:||::|.|::|||.|:|.||.||.:||.:|:||:.|.|:|::...|::.
Human   117 SLFSLWMSSRPATKTMNFGWQRAEILGALVSVLSIWVVTGVLVYLAVERLISGDYEIDGGTMLIT 181

  Fly   241 SGIGIVINIVMMFVLHGSWFVNGNGHGHSHSHSHSHSHSHGNGHEPNDSLSQTRSNSNFLTTIGS 305
            ||..:.:||:|...||.|      ||||||
Human   182 SGCAVAVNIIMGLTLHQS------GHGHSH----------------------------------- 205

  Fly   306 QSASTADEEDSIRKEINSNEHKIVITNGKKPTLTGTSNMELAHEDKNLNLRAAMIHVIGDLVQSI 370
                                              ||:|    .:::|.::|||.||||||.:||:
Human   206 ----------------------------------GTTN----QQEENPSVRAAFIHVIGDFMQSM 232

  Fly   371 GVFLAAVLIKVCPGAKYADPLCTLIFSIIVIMTTLRLFRESLGIIVNAVPQNLNMRTLHLELGSI 435
            ||.:||.::...|..||.||:||.:|||:|:.|||.:.|:.:.:::...|:.::...:...|.|:
Human   233 GVLVAAYILYFKPEYKYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVDFTAVRDLLLSV 297

  Fly   436 EGVRSLHHLNVWQQTSQQRVLMVHLVTDSRADGNEVLQAATALVSSPRYNIKHSTIQLEPTTE 498
            |||.:||.|::|..|..|.||.||:......|...||:.|::.:.. :::....|||:|..:|
Human   298 EGVEALHSLHIWALTVAQPVLSVHIAIAQNTDAQAVLKTASSRLQG-KFHFHTVTIQIEDYSE 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT41F	NP_610185.1	CDF	142..495	CDD:273544	119/352 (34%)
ZnT41F	NP_610185.1	Cation_efflux	142..416	CDD:279834	96/273 (35%)
SLC30A2	NP_001004434.1	CDF	83..357	CDD:273544	120/353 (34%)
SLC30A2	NP_001004434.1	Cation_efflux	83..278	CDD:279834	96/273 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53838
OrthoDB	1	1.010	-	-		D351752at33208
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830