DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT41F and Slc30a4

DIOPT Version :9

Sequence 1:	NP_610185.1	Gene:	ZnT41F / 35513	FlyBaseID:	FBgn0025693	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_035904.2	Gene:	Slc30a4 / 22785	MGIID:	1345282	Length:	430	Species:	Mus musculus

Alignment Length:	456	Identity:	134/456 - (29%)
Similarity:	224/456 - (49%)	Gaps:	74/456 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DDRLSDYQDRYYSVNNNSVNREVVTIGSNVVRVPEEQ-TWEVPLLGDCGDSARNQS---SETEFD 105
            |....|:.|.......:..|:..|.:..:....||.. ....|.|....||..:|.   :.::..
Mouse    25 DTSAFDFSDEVSDEGLSRFNKLRVVVADDDSEAPERPVNGAHPALQADDDSLLDQDLPLTNSQLS 89

  Fly   106 MQRECCNHQPGFRANSKSKSAQEAKYKIMLAVALCCVFMIIEFLGGYVAGSLAIMTDAAHLASDC 170
            ::.:.|::....|...|.:   :.|.::.:|..|..:|||.|.:|||:|.||||||||.|:.:|.
Mouse    90 LKMDPCDNCSKRRELLKQR---KVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDALHMLTDL 151

  Fly   171 ISFVIGLVAIWIGGRPPDERMSFGYKRFEVIGALASILGIWFVTTLLVVVAIERIFSQDFELNAD 235
            .:.::.|:|:|:..:.|..|.:||:.|.||:.|:.|::.::.:...|:..|::|....::|:|.|
Mouse   152 SAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAVQRTIHMNYEINGD 216

  Fly   236 MMMLISGIGIVINIVMMFVLHGSWFVNGNGHGHSHSHSHSHSHSHGNGHEPNDSLSQTRSNSNFL 300
            :|::.:.:|:.:|::|.|:|      |.:||.|||:||||         .|::|.|...|..|
Mouse   217 VMLITAAVGVAVNVIMGFLL------NQSGHHHSHAHSHS---------LPSNSPSMVSSGHN-- 264

  Fly   301 TTIGSQSASTADEEDSIRKEINSNEHKIVITNGKKPTLTGTSNMELAHEDKNLNLRAAMIHVIGD 365
                                                           |...:|.:|||.:|.:||
Mouse   265 -----------------------------------------------HGQDSLAVRAAFVHALGD 282

  Fly   366 LVQSIGVFLAAVLIKVCPGAKYADPLCTLIFSIIVIMTTLRLFRESLGIIVNAVPQNLNMRTLHL 430
            ||||:||.:||.:|:..|..|.|||:||.|||::|..||.|:..:::.||:..||.:||:..:..
Mouse   283 LVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKE 347

  Fly   431 ELGSIEGVRSLHHLNVWQQTSQQRVLMVH--LVTDSRADGNEVLQAATALVSSPRYNIKHSTIQL 493
            .|..||.|.|:..||:|..||.:...:||  |:..|.:...||...|..|:.: .:.:...||||
Mouse   348 SLMKIEDVYSVEDLNIWSLTSGKSTAIVHMQLIPGSSSKWEEVQSKAKHLLLN-TFGMYKCTIQL 411

  Fly   494 E 494
            :
Mouse   412 Q 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT41F	NP_610185.1	CDF	142..495	CDD:273544	116/355 (33%)
ZnT41F	NP_610185.1	Cation_efflux	142..416	CDD:279834	89/273 (33%)
Slc30a4	NP_035904.2	CDF	123..414	CDD:273544	116/355 (33%)
		Cation_efflux	123..333	CDD:279834	89/273 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..264		9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53838
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11562
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850