DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT41F and Slc30a6

DIOPT Version :9

Sequence 1:	NP_610185.1	Gene:	ZnT41F / 35513	FlyBaseID:	FBgn0025693	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001239407.1	Gene:	Slc30a6 / 210148	MGIID:	2386741	Length:	465	Species:	Mus musculus

Alignment Length:	372	Identity:	66/372 - (17%)
Similarity:	133/372 - (35%)	Gaps:	89/372 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 SAQEAKYKIML--AVALCCVFMIIEFLGGYVAGSLAIMTDAAHLASDC-----ISFVIGLVAIWI 182
            :|....:||:|  |:.:.|...::.:...  ..|:|:.........|.     .|.:..|::.|:
Mouse    26 AADRRSWKILLFGAINVLCTGFLLMWCSS--TNSIALTAYTYLTIFDLFSLFFFSLITCLISYWV 88

  Fly   183 GGRPPDERMSFGYKRFEVIGALASI----LGIWFVTTLLVVVAIERIFSQDFELNADMMMLISGI 243
            ..|.|....|||::|.||:...||.    ||..|:    :..:.||...|. |::...:::.:.:
Mouse    89 MMRKPSPVYSFGFERLEVLAVFASTVLAQLGALFI----LKESAERFLEQP-EIHTGRLLVGTFV 148

  Fly   244 GIVINIVMMFVLHGSWFVNGNGHGHSHSHSHSHSHSHGNGHEPNDSLSQTRSNSNFLTTIGSQSA 308
            .:..|:..|..:....|                                         ...|::|
Mouse   149 ALSFNLFTMLSIRNKPF-----------------------------------------AYVSEAA 172

  Fly   309 STADEEDSIRKEINSNEHKIVITNGKKPTLTGTSNMELAHEDKNLNLRAAMIHVIGDLVQSIGVF 373
            ||:..:          ||...::......:.|.|::.|...:.         .|:.||..:..:.
Mouse   173 STSWLQ----------EHVADLSRSLCGLIPGLSSIFLPRMNP---------FVLIDLAGAFALC 218

  Fly   374 LAAVLIKVCPGAKY--ADPLCTLIFSIIVIMTTLRLFRESLGIIVNAVPQNL--NMRTLHLELGS 434
            :..:||::   ..|  .|....:..:::...|...:...|..:::...|.::  .:..|..|:.:
Mouse   219 ITYMLIEI---NNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVST 280

  Fly   435 IEGVRSLHHLNVWQQTSQQRVLMVHLVTDSRADGNEVLQAATALVSS 481
            ::||..:.:.:.|..........||:  ..|.|.||  |...|.||:
Mouse   281 LDGVLEVRNEHFWTLGFGSLAGSVHV--RIRRDANE--QMVLAHVSN 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT41F	NP_610185.1	CDF	142..495	CDD:273544	60/353 (17%)
ZnT41F	NP_610185.1	Cation_efflux	142..416	CDD:279834	44/284 (15%)
Slc30a6	NP_001239407.1	Cation_efflux	43..260	CDD:279834	45/286 (16%)
		CzcD	<83..336	CDD:224151	56/313 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810