DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT41F and ttm-1

DIOPT Version :9

Sequence 1:	NP_610185.1	Gene:	ZnT41F / 35513	FlyBaseID:	FBgn0025693	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_499692.1	Gene:	ttm-1 / 176715	WormBaseID:	WBGene00012712	Length:	410	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	153/464 - (32%)
Similarity:	233/464 - (50%)	Gaps:	99/464 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SVNNNSVNREVVTIGSNVVRVPEEQTWEVPLLGDCGDSA-------------------RNQSSET 102
            |:..:|..|:  :..||:....||.|..|. ..|.|.||                   .:..:..
Worm    10 SIRLSSDKRD--SSSSNLPANIEEDTQSVS-SSDSGVSADSIDHHHHGHGHGHSHGGHGHSHTHN 71

  Fly   103 EFDMQRECCNHQPGFRANSKSKSAQEAK--YKIMLAV-ALCCVFMIIEFLGGYVAGSLAIMTDAA 164
            ..|...:|.....|...:|..:..|:.:  .|::.|| ||..||:..||:||:.|.||||||||.
Worm    72 NDDSSSDCSGAGGGAHKHSHDEKYQKGRRAEKVLWAVAALSAVFIAAEFVGGFWAQSLAIMTDAG 136

  Fly   165 HLASDCISFVIGLVAIWIGGRPPDERMSFGYKRFEVIGALASILGIWFVTTLLVVVAIERIFSQD 229
            |:.||.:||:|.:.||.....|..:|:||||:|.||:|||.|::.:|.:||:||||||:||.:.:
Worm   137 HMLSDLLSFIISIFAIRCARLPASKRLSFGYERAEVLGALTSVIILWVLTTVLVVVAIQRIVNNE 201

  Fly   230 FELNADMMMLISGIGIVINIVMMFVLHGSWFVNGNGHGHSHSHSHSHSHSHGNGHEPNDSLSQTR 294
            .|::||:|::.:|:|::.||||..|||   |..| ||||:|....||.|
Worm   202 HEVDADVMLITAGVGVLFNIVMGLVLH---FGTG-GHGHTHGGHSSHGH---------------- 246

  Fly   295 SNSNFLTTIGSQSASTADEEDSIRKEINSNEHKIVITNGKKPTLTGTSNMELAHEDKNLNLRAAM 359
                                                                ||:.||:|:|||:
Worm   247 ----------------------------------------------------AHDGKNVNVRAAL 259

  Fly   360 IHVIGDLVQSIGVFLAAVLIKVCPGAKYADPLCTLIFSIIVIMTTLRLFRESLGIIVNAVPQNLN 424
            |||||||||||||.:||::|:. .|...|||:||.:|||||:.||:.:.|:...:::.|.|.:.:
Worm   260 IHVIGDLVQSIGVLIAALIIRF-TGWTLADPICTFLFSIIVLFTTVTVMRDIFFVLMEATPSHYD 323

  Fly   425 MRTLHLELGSIEGVRSLHHLNVWQQTSQQRVLMVHLVTDSRADGNEVLQAATALVSSPRYNIKHS 489
            :..:...|.::|||:.:|.|::|.....:....|||..:|.....|.:..|.:|:.. |:.:..:
Worm   324 LSDVKKALSALEGVKGVHDLHLWSIGMDKTAFSVHLALESPNRAMENVAEARSLIRR-RFGVAVA 387

  Fly   490 TIQLEPTTE 498
            |:|:||..|
Worm   388 TVQVEPFDE 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT41F	NP_610185.1	CDF	142..495	CDD:273544	127/352 (36%)
ZnT41F	NP_610185.1	Cation_efflux	142..416	CDD:279834	108/273 (40%)
ttm-1	NP_499692.1	CDF	114..393	CDD:273544	127/352 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167871
Domainoid	1	1.000	221	1.000	Domainoid score	I1493
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H80964
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53838
OrthoDB	1	1.010	-	-		D351752at33208
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11562
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.960