DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7791 and NLN

DIOPT Version :9

Sequence 1:	NP_610183.1	Gene:	CG7791 / 35511	FlyBaseID:	FBgn0033038	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_065777.1	Gene:	NLN / 57486	HGNCID:	16058	Length:	704	Species:	Homo sapiens

Alignment Length:	732	Identity:	185/732 - (25%)
Similarity:	308/732 - (42%)	Gaps:	152/732 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GRTLLRW-------RTRHCSRRVSTWTPLATAFNAPPARRINFTHDDVGLFGMPELRSFEGFYLL 62
            ||.:|||       :||.....|.|                ...:|.||:.|:.|: ::|.....
Human    44 GRNVLRWDLSPEQIKTRTEELIVQT----------------KQVYDAVGMLGIEEV-TYENCLQA 91

  Fly    63 RDNVE----------------SRTQELISEATSDQRRRKMVDIFDELSDSLCKVADLAEFVRIAH 111
            ..:||                |..:|:.:.:|...:|....||  |:|    ...|:  |.||.|
Human    92 LADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDI--EMS----MRGDI--FERIVH 148

  Fly   112 PQSRYTQAAEQACISICGMVESLNTHKPIYKALSHVVDHGDKLPTSEVDRHVSRLFLFDFEQCGI 176
            .|        :.|        .|...||                  |..|::.:..... ::.|:
Human   149 LQ--------ETC--------DLGKIKP------------------EARRYLEKSIKMG-KRNGL 178

  Fly   177 HLPEEERMRVVRLNDYILQLGQKF-----------MSGAVQPSVLP-------------RSQVPE 217
            ||||:.:..:..:...:.:|...|           :....:...||             :.::..
Human   179 HLPEQVQNEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDDKYKITL 243

  Fly   218 SFRNYFPTSGENVIITGLCTNAENVQMREAAYRLYLQPSKSQED---LLRDLLLCRHELARSCGF 279
            .:.:|||       :...|...|..:..|.|:.     ::.:|:   :|:.||..|.::|:..|:
Human   244 KYPHYFP-------VMKKCCIPETRRRMEMAFN-----TRCKEENTIILQQLLPLRTKVAKLLGY 296

  Fly   280 DTYAHRALKGSTMEKPEVVREFIDELSEKLRPRADCDFALMSQMKRRE----GGKADARAEVWDT 340
            .|:|...|:.:|.:....|..|:|:||:||:|..:.:...:..:|::|    |.:.|.:...||.
Human   297 STHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDL 361

  Fly   341 PYY---TNQLRRQLFEEHANEFLPYFSLGGCMEGLDNLLHALYGIRL-QNTDLKPGEAWHNDIYK 401
            .||   |.:|:..:.:|...|   ||.:....|||.|....|.|:.. |.||   ...|:..:..
Human   362 YYYMTQTEELKYSIDQEFLKE---YFPIEVVTEGLLNTYQELLGLSFEQMTD---AHVWNKSVTL 420

  Fly   402 LAVVHEREG-LLGYIYCDFYERVGKPNQDCHFTIQGGKRMPDGSYQLPVVVVMLGLAQPRWSGPT 465
            ..|..:..| :||..|.|.|.|.||.|....|.:|.|..:||||..:.|..:::..:||....|:
Human   421 YTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPVAGRPS 485

  Fly   466 LLSPARLDNLFHEMGHAMHSMLARTEHQHVTGTRCSTDFAEVPSVLMEYFAGDPRVLRTFARHFQ 530
            ||....:...|||.||.||.:.|:|:....:||...|||.||||.::|.:..|...||..::|::
Human   486 LLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYK 550

  Fly   531 THEPISEDMLRRLCASKNLFAASETQLQVFYSALDQEYH-----GASARHGQSSTDTLRSVQDHY 590
            ...||::|:|.:|.||:.:.....|..|:..|.:||..|     .|::.:.:..::.|
Human   551 DGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAASEYAKYCSEIL------- 608

  Fly   591 YGLPYVDNTAWQLRFSHLV-GYGAKYYAYLVSKTIASWIWQTYFEANP-FNRQAGEKYRAEILAH 653
             |:.....|.....|.||. ||..:||.||.|:..:..::.:.|:... .|.:.|.|||..||..
Human   609 -GVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKP 672

  Fly   654 GGAVPSRKLVANFLQRE 670
            ||::....::.|||:||
Human   673 GGSLDGMDMLHNFLKRE 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7791	NP_610183.1	M3A_MIP	46..680	CDD:188996	174/684 (25%)
NLN	NP_065777.1	Dcp	54..701	CDD:223416	180/722 (25%)
NLN	NP_065777.1	M3A_TOP	58..699	CDD:188994	180/718 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D642479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820