DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7791 and Thop1

DIOPT Version :9

Sequence 1:	NP_610183.1	Gene:	CG7791 / 35511	FlyBaseID:	FBgn0033038	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_073144.3	Gene:	Thop1 / 50492	MGIID:	1354165	Length:	687	Species:	Mus musculus

Alignment Length:	690	Identity:	168/690 - (24%)
Similarity:	287/690 - (41%)	Gaps:	90/690 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 APPARRINFTHDDVGLFGMPELRSFEGFYLLRDNVESRTQELISEATSDQRRRKMVDIFDELS-- 94
            |.||..:|....|                |....:.:.|.:|| |.|.....|.....|:::|
Mouse    15 ASPASTVNHLRWD----------------LSAQQIRALTTQLI-EQTKCVYDRVGAQNFEDVSYE 62

  Fly    95 DSLCKVAD----------LAEFVRIAHPQSRYTQAAEQACISICGMVESLNTHKPIYKALSHVVD 149
            .:|..:||          :.:|.:...|......|:.:|...:......::..:.:|:   .||.
Mouse    63 STLKALADVEVTYTVQRNILDFPQHVSPCKDIRAASTEADKKLSEFDVEMSMRQDVYQ---RVVW 124

  Fly   150 HGDKLPTS----EVDRHVSRLFLFDFEQCGIHLPEEERMRVVRLNDYILQLGQKFMSGAVQPSV- 209
            ..:|.|..    |..|::.||.... .:.|:|||::.:.::..:...:..|...|.....:.:.
Mouse   125 LQEKTPKDSLKPEAARYLERLIKLG-RRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTF 188

  Fly   210 LPRSQ-----VPESF------------------RNYFPTSGENVIITGLCTNAENVQMREAAYRL 251
            ||.::     :||.|                  .:|||       :...|...|..::.|.|:.
Mouse   189 LPFTREELGGLPEDFLSSLEKAEDGKLKVTLKYPHYFP-------LLKKCHVPETRRLLEEAFN- 245

  Fly   252 YLQPSKSQED---LLRDLLLCRHELARSCGFDTYAHRALKGSTMEKPEVVREFIDELSEKLRPRA 313
                .:.:|:   :|::|:..|.:.:...||.|:|...|:.:..:..:.|..|:|||::||:|..
Mouse   246 ----CRCKEENCAILKELVSLRAQKSSLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLG 306

  Fly   314 DCDFALMSQMKRREGGKA----DARAEVWDTPYYTNQLRRQLFEEHANEFLPYFSLGGCMEGLDN 374
            :.:.|::.::|..|..|.    |.|...||..||.||:....:....|....||.:.....||..
Mouse   307 EQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLA 371

  Fly   375 LLHALYGIRLQNTDLKPG-EAWHNDIYKLAVVHEREG-LLGYIYCDFYERVGKPNQDCHFTIQGG 437
            :...|.|:..   .|:.| .|||.|:...:|.....| .:|..|.|.|.|.||......|.:|.|
Mouse   372 IYQELLGLTF---TLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPG 433

  Fly   438 KRMPDGSYQLPVVVVMLGLAQPRWSGPTLLSPARLDNLFHEMGHAMHSMLARTEHQHVTGTRCST 502
            ....|||.||.|..::....:|....|:||....::..|||.||.||.:.::.|....:||....
Mouse   434 CLRQDGSRQLAVAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVER 498

  Fly   503 DFAEVPSVLMEYFAGDPRVLRTFARHFQTHEPISEDMLRRLCASKNLFAASETQLQVFYSALDQE 567
            ||.|.||.::|.:..:...|...::|::|.....:|:|.:|..|:...|......|:..:.:||.
Mouse   499 DFVEAPSQMLENWVWEKEPLMRMSQHYRTGSEAPQDLLEKLIKSRQANAGLFNLRQIVLAKVDQV 563

  Fly   568 YHGASARHGQSSTDTLRSVQDHYYGLPYVDNTAWQLRFSHLV-GYGAKYYAYLVSKTIASWIWQT 631
            .|  :......:.:..|..|: ..|:|....|.....|.||. ||.|:||.||.|:..:..::.|
Mouse   564 LH--TQTDADPAEEYARLCQE-ILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHT 625

  Fly   632 YF-EANPFNRQAGEKYRAEILAHGGAVPSRKLVANFLQRE 670
            .| :....:.:.|..||..||..||:..:..::..||.|:
Mouse   626 RFKQEGVLSPKVGMDYRTSILRPGGSEDASAMLKQFLGRD 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7791	NP_610183.1	M3A_MIP	46..680	CDD:188996	163/676 (24%)
Thop1	NP_073144.3	M3A_TOP	35..675	CDD:188994	162/654 (25%)
Thop1	NP_073144.3	Dcp	37..679	CDD:223416	162/652 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1976
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760