DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7791 and FREM2

DIOPT Version :9

Sequence 1:	NP_610183.1	Gene:	CG7791 / 35511	FlyBaseID:	FBgn0033038	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_997244.4	Gene:	FREM2 / 341640	HGNCID:	25396	Length:	3169	Species:	Homo sapiens

Alignment Length:	272	Identity:	55/272 - (20%)
Similarity:	97/272 - (35%)	Gaps:	68/272 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 ANEFLPYFS----LGGCMEGLDNLLHALYGIRLQNTDLKPGE----AWHNDIY--KLAVVHEREG 410
            |:.::|.:|    ..||:....:||:     |.:..|....|    ::.|.::  ||| |.:.|.
Human  2923 ADGYVPKYSPMNAEYGCLADSPSLLY-----RFKIVDKAQPETQATSFGNVLFNAKLA-VDDPEA 2981

  Fly   411 LLGYIYCDFYERVGKPNQDCHFTIQGGKRMPDGSYQLPVVVVMLGLAQPRWSGPTLLSPARLDNL 475
            :|         .|.:|..| .|.:.          ..|:..|.||   ..|...|:.:....||.
Human  2982 IL---------LVNQPGSD-GFKVD----------STPLFQVALG---REWYIHTIYTVRSKDNA 3023

  Fly   476 FHEMGH---AMHSMLARTEHQHVTGTRCSTDFAEVPSVLMEYFAGDPRVLRTFARH--------- 528
            ...:|.   ..||::::.:.|..|.:|...:....||:..|..|.:.|  .|..:|
Human  3024 NRGIGKRSVEYHSLVSQGKPQSTTKSRKKREIRSTPSLAWEIGAENSR--GTNIQHIALDRTKRQ 3086

  Fly   529 -------------FQTHEPISEDMLRRLC--ASKNLFAASETQLQVFYSALDQEYHGASARHGQS 578
                         ::.:.|.|...|..:.  .:..|.....|.:.|......:.:.|..|..|.|
Human  3087 IPHGRAPPDGILPWELNSPSSAVSLVTVVGGTTVGLLTICLTVIAVLMCRGKESFRGKDAPKGSS 3151

  Fly   579 STDTLRSVQDHY 590
            |::.:...|.|:
Human  3152 SSEPMVPPQSHH 3163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7791	NP_610183.1	M3A_MIP	46..680	CDD:188996	55/272 (20%)
FREM2	NP_997244.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	319..413
		Cadherin_3	383..539	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	438..537
		Cadherin_3	507..676	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	560..675
		Cadherin_3	645..808	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	700..807
		Cadherin_3	774..920	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	828..919
		Cadherin_3	890..1038	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	945..1037
		Cadherin_3	1004..1170	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1066..1168
		Cadherin_3	1136..1284	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1189..1282
		Cadherin_3	1252..1401	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1303..1399
		Cadherin_3	1370..1514	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1420..1512
		Cadherin_3	1482..1623	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1532..1621
		Cadherin_3	1592..1754	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1655..1752
		Calx-beta	1771..1858	CDD:295344
		Calx-beta	1882..1982	CDD:295344
		Calx-beta	2008..2102	CDD:295344
		Calx-beta	2128..2220	CDD:295344
		Calx-beta	2249..2341	CDD:295344
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3057		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3141..3169		7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900