DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7791 and Frem2

DIOPT Version :9

Sequence 1:	NP_610183.1	Gene:	CG7791 / 35511	FlyBaseID:	FBgn0033038	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_766450.2	Gene:	Frem2 / 242022	MGIID:	2444465	Length:	3160	Species:	Mus musculus

Alignment Length:	642	Identity:	123/642 - (19%)
Similarity:	192/642 - (29%)	Gaps:	184/642 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLRDNVESRTQELISEATSDQRRRKMVDIFDELSDSLCKVADLAEFVRIAHPQSRY-----TQAA 120
            |:.|.|....:||.....:.|..........|.:::|.|:.|.|:...|...::::     ::..
Mouse  2192 LMDDAVYEDVEELRLVLGTPQGSSAFGAAVGEQNETLIKIQDEADKAVIKFGETKFSVTEPSRPG 2256

  Fly   121 EQACISI-------CGMVESLNTHKPIYKALS----HVVDHGDKLPTSEVDRHVSRLFLFD---- 170
            |...:.|       ...|..:..|.....|.|    |.|....:....|....|....:||
Mouse  2257 ESVVVKIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHTVEIEVIFDGVRE 2321

  Fly   171 -FEQCGIHLPEEERM----RVVRLNDYILQLGQKFMSGAVQPSV------LPRSQVPESFRNYFP 224
             .|...:||..:|.|    :..:...||.::..  |:....|||      |......:...:..|
Mouse  2322 MREAFTVHLKPDENMVAETQATKAIVYIEEIHS--MADVTFPSVPHIVSLLIYDDPSKGREDTGP 2384

  Fly   225 TSGENVII-------------TGLCTNAENVQMREAAYRLYLQPSKSQEDLLRDLLLCRHELARS 276
            .||..|:.             ||....:||:......||..:......:.:...:        |.
Mouse  2385 VSGYPVVCITACNPKYPDYEKTGSICASENINDTLTRYRWLISAPAGPDGVTSPM--------RE 2441

  Fly   277 CGFDTYAHRALKGSTMEKPEVVREFIDELSEKLRPRADC-----------DFALMSQMKR--REG 328
            ..|||:    ...|.|..       :|.:..:...|..|           ...|||.:..  ||.
Mouse  2442 VDFDTF----FTSSKMIT-------LDSIYFQPGSRVQCAARAVNTNGNEGLELMSPIVTIGREE 2495

  Fly   329 GKADAR------AEVW---------DTPYYTNQLRRQLFEEHANEFLPYFS-------------- 364
            |....|      ||.:         :.|.:.|.::..:...|.:..||..|
Mouse  2496 GLCQPRVPGVVGAEPFSAKLRYTGPEDPDFANLIKLTVTMPHIDGMLPAISTRELSNFELTLSPD 2560

  Fly   365 ---LGG--CMEGLD-NLLHALYGIRLQNTDLKP---GEAWHNDIYKLAVVHEREGLLGYI----- 415
               :|.  |...|| |.:...:|. |.|....|   ||.:.   |:.:|.......|.:.
Mouse  2561 GTRVGNHKCSNLLDYNEVKTHHGF-LTNATKNPEVIGETYP---YQYSVPVRGSSTLRFYRNLNL 2621

  Fly   416 ---------YCDFYERVGKPNQDCHFTIQGGKRMPDGSYQLPVVVVMLGLAQPRWSGPTLLSPAR 471
                     |.|..|.:.    ||     ||....||.        :|.|.|   |..||..|..
Mouse  2622 EACLWEFVSYYDMTELLA----DC-----GGTIGTDGQ--------VLNLVQ---SYVTLRVPLY 2666

  Fly   472 LDNLFHE---MGHAMHSMLARTEHQHVTGTRCSTDFAEVPSVLMEYFAGDPRVLRTFARHFQTHE 533
            :..:||.   :|...|..|.         :.....|....::|..:..|.|.........:.|..
Mouse  2667 VSYVFHSPVGVGGWQHFDLK---------SELRLTFVYDTAILWNHGIGSPPEAELQGSLYPTSM 2722

  Fly   534 PISEDMLRRLCASKNLFAASETQLQVFYSALDQEYHGASA-RHGQSSTDTLRSVQDH 589
            .|.|                |.:|.|.:.. :.::||... .|..|.|.:|....||
Mouse  2723 RIGE----------------EGRLAVNFKT-EAQFHGLFVLSHPASFTSSLIVSADH 2762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7791	NP_610183.1	M3A_MIP	46..680	CDD:188996	123/642 (19%)
Frem2	NP_766450.2	CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	312..406
		Cadherin_3	376..532	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	431..530
		Cadherin_3	500..665	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	553..664
		Cadherin_3	634..797	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	689..796
		Cadherin_3	763..909	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	817..908
		Cadherin_3	879..1026	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	934..1026
		Cadherin_3	993..1159	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1055..1157
		Cadherin_3	1125..1273	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1178..1271
		Cadherin_3	1241..1390	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1292..1388
		Cadherin_3	1359..1503	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1409..1501
		Cadherin_3	1471..1612	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1521..1610
		Cadherin_3	1581..1742	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1644..1741
		Calx-beta	1760..1847	CDD:295344
		Calx-beta	1871..1971	CDD:295344
		Calx-beta	1999..2091	CDD:295344
		Calx-beta	2117..2209	CDD:295344	5/16 (31%)
		Calx-beta	2239..2330	CDD:295344	14/90 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3130..3160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900