Protein Alignment IKBKB and IKS1

DIOPT Version :9

• Sequence 1: XP_005273547.1
• Gene: IKBKB / 3551
• HGNCID: 5960
• Length: 805
• Species: Homo sapiens
• Sequence 2: NP_012478.3
• Gene: IKS1 / 853389
• SGDID: S000003593
• Length: 667
• Species: Saccharomyces cerevisiae
• Alignment Length: 433
• Identity: 101/433 - (23%)
• Similarity: 159/433 - (36%)
• Gaps: 131/433 - (30%)

Human    21 LGTGGFGNVIR-WH---NQETGEQIAIKQCRQELSPRNRERW---CL-EIQIMRRLTH--PNVVA 75
            ||.|..|:|.: .|   |.|.| ..|:|    ::...|...|   |: |::.:..|||  .|::.
Yeast   179 LGNGARGSVYKVVHTIGNTELG-VFALK----KIPIGNDMEWFNKCIREVKALSSLTHKSANLIT 238

Human    76 ARDV-------------PEGMQNLAPNDLP--LLAMEYCQGGD-----LRKYLNQFENC------ 114
            ...|             .:|.|:.:..::|  .:..:||.||:     |||..|:|.:.
Yeast   239 YNHVWLEMDSSVGFVRSIDGSQSDSQEEVPCIFILQQYCSGGNLEDCILRKVFNRFSDTESPEER 303

Human   115 ----------------CGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVL---------- 153
                            .||....:::::.|||..|..||...:|||||||.|.:|
Yeast   304 KKKFRTRKKNHGKSGEVGLSTEQLVSIIRDIARGLHELHSIGLIHRDLKPSNCLLLTPFKSDNEN 368

Human   154 ------QQGEQRLIHKII--DLGYAKELDQGSLCTSFVGTLQYLAPELLEQ-------------- 196
                  :.........|:  |||.::...:..|.|...|||::.||:|:.|
Yeast   369 DNVYDREHNSDEFFPSIVIGDLGESQLEGESRLGTGCTGTLEFTAPDLIIQGRPVSSSTLPSRSS 433

Human   197 ---QKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVK---- 254
               .:||...|.:|.|.:.:..:.|..||.|....|.  .|||.|:     ...|..|.::
Yeast   434 HTYNEYTFASDMYSLGMICYFIVFGELPFEPQLDIVD--LKVRIKN-----FRFDTEGMIEKHQA 491

Human   255 ------------FSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDIL 307
                        ...:|..|||.....|:.:|:.|..||:      .:.|  |.....:.:|..|
Yeast   492 MKLKPIDRRIFHLMDALLQPNNDARPTAKTVEETLDEMLI------NSKP--GKKFWKENVDSTL 548

Human   308 NLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEED 350
            |...:..:|..|.:.....:..|....||.|        |||:
Yeast   549 NFSTISEVNENTNSFTDDYIDGDNVTLSLPA--------PEEN 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKBKB	XP_005273547.1	S_TKc	15..290	CDD:214567	87/371 (23%)
		STKc_IKK_beta	20..309	CDD:270940	91/390 (23%)
		GVQW	785..>805	CDD:290611
IKS1	NP_012478.3	PKc_like	173..522	CDD:419665	83/354 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910