DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKBKB and ikbkb

DIOPT Version :9

Sequence 1:	XP_005273547.1	Gene:	IKBKB / 3551	HGNCID:	5960	Length:	805	Species:	Homo sapiens
Sequence 2:	NP_001116737.1	Gene:	ikbkb / 563560	ZFINID:	ZDB-GENE-071115-2	Length:	779	Species:	Danio rerio

Alignment Length:	768	Identity:	453/768 - (58%)
Similarity:	542/768 - (70%)	Gaps:	35/768 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIM 65
            ||..||:..||||.||:||||||||||||..|.|:||..||||||||||||.:|:.||.||||||
Zfish     1 MSRPPSMQPQTCGPWELKERLGTGGFGNVTLWQNKETSIQIAIKQCRQELSVKNKGRWSLEIQIM 65

Human    66 RRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIA 130
            :||||.||||||||||.:|.||.|||||||||:|||||||||||..|||||:||.|:|||:.||:
Zfish    66 KRLTHMNVVAARDVPEELQKLATNDLPLLAMEFCQGGDLRKYLNLVENCCGMREAAVLTLIQDIS 130

Human   131 SALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLE 195
            |||.|||..||||||||||||||||||:||:||||||||||||||.|||||||||||||||||||
Zfish   131 SALTYLHGMRIIHRDLKPENIVLQQGEKRLVHKIIDLGYAKELDQSSLCTSFVGTLQYLAPELLE 195

Human   196 QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLP 260
            ||||||.|||||||||.||||||||||||.|||||||||::||...||||.|||.|.|::|..||
Zfish   196 QQKYTVAVDYWSFGTLVFECITGFRPFLPTWQPVQWHSKLQQKHVDDIVVYEDLGGEVRYSKHLP 260

Human   261 YPNNLNSVLAERLEKWLQLMLMWHPRQRGTD-------------------PTYGPNG-------- 298
            .|:|||.:||..||:|||:||.|.|::||.|                   ....|.|
Zfish   261 NPHNLNKLLAGELERWLQMMLRWSPKERGKDLKQRNKESQETPKDAEEESKETSPEGAKDAPKAP 325

Human   299 --CFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLAL 361
              ||..|..||||||||:|||.:..|..|.|..::.:.||:.||.||||||..:||||.||||||
Zfish   326 CFCFDELSHILNLKLVHVLNMTSAEIFNYSVQPEDDVASLQERIAQDTGIPPANQELLLEAGLAL 390

Human   362 IPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQL 426
            .|.....||..|..|.:....|..||||||.|..:||.|.:||..||::..:..||||.|.:...
Zfish   391 EPQNSVMQCAIDYSLMDNRRADEPLVFLFDRSCCSYEPQFTPRVLPENIRFVQNEPKRPLPYSSQ 455

Human   427 RKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQ 491
            |:.|||.||:|:.||||..||||||:.|:|:|||:|..|||.||.|.||.|:|||.||||..|:.
Zfish   456 RRTWGQAWHTIRALKEDWQRLQQGQKVAIMSLLRHNGTLSKQKNEMVSMHQRLKATLDFFGASLH 520

Human   492 IDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQ 556
            :|:.||.||...||.|:|||..||||||....||:..:|..|.|.||.||||||||||.|.  :.
Zfish   521 VDISKYQEQRATGIASEKLLSVWREMEQTALDCGQTEDVFKLEEEMMTLQTDIVDLQRQPW--RS 583

Human   557 GGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQK 621
            |..|:.||.:|.||:|:||||||:||:.||.||:::|::||:|.:|:|:|..||.||||:||:|:
Zfish   584 GEALETLEVKAMELFRKLREKPREQRSMGDCQEVIKLVVQAVQFYERKLRDFYTHLSKTMVCRQR 648

Human   622 ALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQ 686
            .|.|||:||.:||.|...||.::.||||||||||||||:||||||.|||||||.........| |
Zfish   649 VLALLPRVEGLVSAMARSEKQLLHLQEKRQKELWNLLKVACSKVRSPVSGSPDGGRTPPAPTP-Q 712

Human   687 LMSQPSTASNSLPEPAKKSEE---LVAEAHNLCTLLENAIQDTVREQDQSFTV 736
            |||...:..:|.|.....:||   ::.|:......|::.:|||::|.:.|..:
Zfish   713 LMSHRPSHPSSPPSDGPHTEESLHVIEESRIFENRLQSLVQDTIQETESSMQI 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKBKB	XP_005273547.1	S_TKc	15..290	CDD:214567	214/274 (78%)
		STKc_IKK_beta	20..309	CDD:270940	219/317 (69%)
		GVQW	785..>805	CDD:290611
ikbkb	NP_001116737.1	STKc_IKK_beta	20..338	CDD:270940	219/317 (69%)
ikbkb	NP_001116737.1	TGS	329..>380	CDD:330245	26/50 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337057
Domainoid	1	1.000	446	1.000	Domainoid score	I3650
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7782
Inparanoid	1	1.050	886	1.000	Inparanoid score	I2921
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43878
OrthoDB	1	1.010	-	-		D1013139at2759
OrthoFinder	1	1.000	-	-		FOG0003594
OrthoInspector	1	1.000	-	-		oto48726
orthoMCL	1	0.900	-	-		OOG6_105964
Panther	1	1.100	-	-	LDO	PTHR22969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6738
SonicParanoid	1	1.000	-	-		X2467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300