DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKBKB and IKKepsilon

DIOPT Version :9

Sequence 1:	XP_005273547.1	Gene:	IKBKB / 3551	HGNCID:	5960	Length:	805	Species:	Homo sapiens
Sequence 2:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	169/780 - (21%)
Similarity:	307/780 - (39%)	Gaps:	191/780 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDV 79
            |.....||.|..|:|.:..|:.|||.:|:|........|..:....|.:.::::.|.|:|....:
  Fly    12 WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHENIVKLLAI 76

Human    80 PEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHR 144
            .|..:...    .::.||.|.||.|...|:..||..||.|...|.:|..:.:.:::|.:|:::||
  Fly    77 EEDQEGRG----KVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHR 137

Human   145 DLKPENI---VLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLE--------QQK 198
            ||||.||   :.:.|:  .|:|:.|.|.|:||:......|..||.:||.|:|.|        |:.
  Fly   138 DLKPGNIMKFISEDGQ--TIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQRS 200

Human   199 YTVTVDYWSFGTLAFECITG---FRPFLPNWQPVQWHSKVRQKSEVDIVVSEDL--NGTVKFSSS 258
            :|..||.||.|...:...||   ||||.........| ::..|....::....|  ||.:::|::
  Fly   201 FTANVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMH-QITTKKASGVISGTQLSENGPIEWSTT 264

Human   259 LPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHI-LNMVTGTI 322
            ||...:|:..|     |.|...|:....:...:.|:..:..|..:..||..:::|: ....|.::
  Fly   265 LPPHAHLSQGL-----KTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSV 324

Human   323 HTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLV 387
            ..: :..||.:.:.:.||...|.:|.|.|                                   :
  Fly   325 EVF-LEPDEQIDNFRERIFLQTEVPLEKQ-----------------------------------I 353

Human   388 FLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQR 452
            .||:|..:  |.:::||...::......:                  ..|.....|.|.:|..|:
  Fly   354 LLFNNEHL--EKKVTPRTIAKAFPATTTD------------------QPIFLYSNDDNNVQLPQQ 398

Human   453 AAMMNL--------LRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQ-TEFGITSD 508
            ..:...        :.|::.|:|   |..|:..:.|.::|.| ||:.|.::|..|. .|..:|:.
  Fly   399 LDLPKFPVFPPNVSVENDASLAK---SACSVGHECKRRVDIF-TSMDILIKKGVEHFIEMLVTTI 459

Human   509 KLLLAWRE---------------MEQAVELCGRENEVKLLVERMMALQTD--------------- 543
            .|||...|               :.....:...:.|:|.|:..:..:::|
  Fly   460 TLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTALENVKSDFDGAADVISQMHKHF 524

Human   544 -----IVDLQRSPMGRKQGGTLDDLEEQARELYRRLREK----PRDQRTE----GDSQ------- 588
                 :.|...|.|..|:.........||:.|..|||:.    .||:.|.    .|.|
  Fly   525 VIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQHLLRDRATRTLTYNDEQFHALEKI 589

Human   589 ------EMVRLLL------------QAIQSFEKKVRVIY--TQLSKTVV--CKQKALELLPKVEE 631
                  :.::.||            :.:..:.|..:.:|  ||:.:..|  |::|...:..::..
  Fly   590 KVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLKTQILEKDVRDCERKLNGIRDELYH 654

Human   632 VVS--LMNEDEKTV--------------VRLQEKRQKELWNLLK-----IACSKVRGPVSGSPDS 675
            |.|  .::.|.||:              :|:.:::|:|:..:::     |:.....|..:||.:|
  Fly   655 VKSELKLDVDTKTINNNNQLAKIEERNRLRVMQQQQQEVMAVMRTNSDIISLLSKLGITNGSLES 719

Human 676 675
Fly 720 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKBKB	XP_005273547.1	S_TKc	15..290	CDD:214567	84/290 (29%)
		STKc_IKK_beta	20..309	CDD:270940	87/304 (29%)
		GVQW	785..>805	CDD:290611
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	84/292 (29%)
		STKc_TBK1	18..332	CDD:270890	89/326 (27%)
		UBL_TBK1_like	299..389	CDD:240618	20/145 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770