DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKBKB and nak1

DIOPT Version :9

Sequence 1:	XP_005273547.1	Gene:	IKBKB / 3551	HGNCID:	5960	Length:	805	Species:	Homo sapiens
Sequence 2:	NP_596023.1	Gene:	nak1 / 2539963	PomBaseID:	SPBC17F3.02	Length:	652	Species:	Schizosaccharomyces pombe

Alignment Length:	806	Identity:	170/806 - (21%)
Similarity:	285/806 - (35%)	Gaps:	248/806 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    19 ERLGTGGFGNVIRWHNQETGEQIAIK-----QCRQELSPRNRERWCLEIQIMRRLTHPNVVAARD 78
            |.:|.|.:|.|.|.....|.|.:|||     ....|:|...:     |:.::..|...:|
pombe    14 ELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQK-----EVAVLSELKQSDV----- 68

Human    79 VPEGMQN--------LAPNDLPLLAMEYCQGGDLRKYLNQFENCCG-LREGAILTLLSDIASALR 134
                 :|        |...:|.:: |:||.||.:|..:.     .| :.|..|..:|.:...||:
pombe    69 -----ENIIKYHGSYLVGTNLWII-MDYCHGGSVRTLME-----AGPISEPCISLILRETLQALK 122

Human   135 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELD-QGSLCTSFVGTLQYLAPELL-EQQ 197
            ::|...|||||:|..||::.....   .|:.|.|.|.||: ......:|:||..::|||:: :.|
pombe   123 FIHHAGIIHRDIKAANILVSMSGN---VKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQ 184

Human   198 KYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIV---VSEDLNGTVKFSSSL 259
            :|.|..|.||.|..|:|..||..|          |:|......|.::   ....|||
pombe   185 EYNVMADIWSLGITAYEIATGSPP----------HAKEDPFRAVYLIAHTAPPRLNG-------- 231

Human   260 PYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALD--DILNLKLVH-----ILNM 317
                |.:::|.|.:...||.:    |::|              ||  ::|..|.:.     .::.
pombe   232 ----NFSALLKEFIASCLQDV----PQRR--------------LDSSELLKSKFIKQYSRMSISE 274

Human   318 VTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELL--QEAGLALIPDKPA--TQCISDG---- 374
            :|..:..|...            |...|||   |.||  :||.....||:..  |....||
pombe   275 LTNVVKRYDTW------------QAAGGIP---QTLLLGEEADDGSDPDQETSDTAASDDGWEFG 324

Human   375 --KLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSI 437
              |..:.:...:........:..|..|.::....|:| |.:.:.|..|
pombe   325 TIKQGQSNVSSITGTSTSTTTAATSSTTVTGTVIPKS-STVHEPPSSN----------------- 371

Human   438 QTLKEDCNRLQQGQRAAMMNLLRNNSCLS---KMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSE 499
                 |.:.|.|         |..:|.:|   ...|:..:.::..|.::.:    .||:|.....
pombe   372 -----DSHPLLQ---------LFKDSKISDDDSPSNAEGASTEDSKGEVSY----SQIELPSLDS 418

Human   500 QTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLE 564
            .   .::|.|..:..:..:||       .:..|.|.|.                |....|..| :
pombe   419 S---NLSSKKSTIQSKHTKQA-------EDYDLFVGRT----------------RSNSKTSSD-Q 456

Human   565 EQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVI----YTQLSKTVVC---KQKA 622
            ...|.|.|.::.:.......|.|...::..|:...||:.:.|.|    :.|||..:..   |..|
pombe   457 SIKRPLPRVVQRQKTSLGKRGISMSPMKPGLRMPSSFDLQSRSISMGAFEQLSTPLEAPAHKHSA 521

Human   623 LELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI-AC--------SKVRG---PVS-GSP- 673
            :....:|...:|:......:...|.:...:...:..|| :|        ||:|.   |:| |||
pombe   522 VLQPLEVNRSISIPPPKSISPSILHKPSLESASSTPKISSCSSTPKPFNSKLRAHLPPLSIGSPA 586

Human   674 ---------DSMNASRLSQ------PGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAI 723
                     ||:....|:.      ||.:                         ||:.::|...|
pombe   587 VQPLANDNYDSLGVRGLNMELFNDYPGNM-------------------------HNIKSVLSLEI 626

Human   724 QDTVREQDQSFTVTACVRLLRFHVLS 749
            ...:.|.|      ||::.|..::|:
pombe   627 DIVLGEMD------ACLKSLECNLLN 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKBKB	XP_005273547.1	S_TKc	15..290	CDD:214567	77/289 (27%)
		STKc_IKK_beta	20..309	CDD:270940	79/309 (26%)
		GVQW	785..>805	CDD:290611
nak1	NP_596023.1	PKc_like	8..282	CDD:304357	82/331 (25%)
nak1	NP_596023.1	S_TKc	10..264	CDD:214567	81/313 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910