DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ap and LHX2

DIOPT Version :9

Sequence 1:	NP_724428.1	Gene:	ap / 35509	FlyBaseID:	FBgn0267978	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens

Alignment Length:	394	Identity:	171/394 - (43%)
Similarity:	227/394 - (57%)	Gaps:	69/394 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 RATFEDSAAKFSISRSRTDCTEVSDETTSGISFKTEPFGPPSSPESTSDSKITRNLDDCSGCGRQ 154
            ||..|..|...:|.|..|:.|                     .|..:||....     |:|||.:
Human    21 RAKSEAPAISSAIDRGDTETT---------------------MPSISSDRAAL-----CAGCGGK 59

  Fly   155 IQDRFYLSAVEKRWHASCLQCYACRQPLERESSCYSRDGNIYCKNDYYSFFGTRRCSRCLASISS 219
            |.||:||.||:|:||..||:|..|:..||.|.:|:|:||:||||.|||..|..:||:||...||:
Human    60 ISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISA 124

  Fly   220 NELVMRARNLVFHVNCFCCTVCHTPLTKGDQYGIIDALIYCRTHYSIAREG---------DTASS 275
            :|:|||||:||:|:|||.||.|:..||.||.:|:.|:|:|||.|:....:|         |.|::
Human   125 SEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAA 189

  Fly   276 SMSATYPYSAQFGSPHNDSSSPHSDPSRSIVPTGIFVPASHVINGLPQPARQKGRPRKRKP---- 336
            :.:|....||..|:.   .::|...|..:.|.|                 .|||||||||.
Human   190 AAAAAAAKSAGLGAA---GANPLGLPYYNGVGT-----------------VQKGRPRKRKSPGPG 234

  Fly   337 KDIEAFTANIDLN---TEYVDFGRGSHLSSSSRTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLK 398
            .|:.|:.|.:..|   .|::|  |.....||.:||||||||||||||||||||||||||||||||
Human   235 ADLAAYNAALSCNENDAEHLD--RDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLK 297

  Fly   399 QLSQKTGLPKRVLQVWFQNARAKWRRMMMKQDGSGLLEKGEGALDLDSISVHSPTSFILG---GP 460
            ||:|||||.||||||||||||||:||.:::|:.:|:.:..:.||...:.|  .|.|.:..   .|
Human   298 QLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPS--GPASELSNASLSP 360

  Fly   461 NSTP 464
            :|||
Human   361 SSTP 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ap	NP_724428.1	LIM1_Lhx2_Lhx9	148..201	CDD:188755	29/52 (56%)
		LIM2_Lhx2_Lhx9	206..264	CDD:188763	31/57 (54%)
		Homeobox	371..424	CDD:395001	49/52 (94%)
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	32/67 (48%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	31/57 (54%)
		COG5576	<247..378	CDD:227863	72/122 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		8/21 (38%)
		Homeobox	270..323	CDD:395001	49/52 (94%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		14/15 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6077
eggNOG	1	0.900	-	-		E33208_3BD2S
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55848
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2768
Isobase	1	0.950	-	0	Normalized mean entropy	S3827
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174930at2759
OrthoFinder	1	1.000	-	-		FOG0002416
OrthoInspector	1	1.000	-	-		otm40827
orthoMCL	1	0.900	-	-		OOG6_105440
Panther	1	1.100	-	-	O	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3033
SonicParanoid	1	1.000	-	-		X1607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810