DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ap and lhx2b

DIOPT Version :9

Sequence 1:	NP_724428.1	Gene:	ap / 35509	FlyBaseID:	FBgn0267978	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001035099.3	Gene:	lhx2b / 791744	ZFINID:	ZDB-GENE-051220-1	Length:	427	Species:	Danio rerio

Alignment Length:	419	Identity:	179/419 - (42%)
Similarity:	240/419 - (57%)	Gaps:	60/419 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 CSS--SSCPDICDHSTKPFGNAYGTESFRSYETADRATFEDSAAKFSISRSRTDCTEVSDETTSG 119
            |.|  ::|..:...:|..|....|.|.....|..:|             |.::|...:|.....|
Zfish    16 CRSDGNTCYSVSSAATMLFHGLPGGEMHGVMEEMER-------------RGKSDSATISSAIDMG 67

  Fly   120 ISFKTEPFGPPSSPESTSDSKITRNLDDCSGCGRQIQDRFYLSAVEKRWHASCLQCYACRQPLER 184
               :||...|     |.|..::..    |:|||.:|.||:||.||:|:||..||:|..|:..||.
Zfish    68 ---ETETNMP-----SISGDRVAL----CAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLES 120

  Fly   185 ESSCYSRDGNIYCKNDYYSFFGTRRCSRCLASISSNELVMRARNLVFHVNCFCCTVCHTPLTKGD 249
            |.:|:|:||:||||.|||..|..:||:||...||::|:|||||:||:|:|||.||.|:..||.||
Zfish   121 ELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGD 185

  Fly   250 QYGIIDALIYCRTHYSIAREGDTASSSMSATYPYSAQFGSPHNDSSSPHSDPSRSIVPTGIFVPA 314
            .:|:.|:|:|||.|:....:||           :...|.  |.|.:     |::.:..||   |.
Zfish   186 HFGMKDSLVYCRLHFETLIQGD-----------FPTHFN--HTDVA-----PNKGLSSTG---PL 229

  Fly   315 S-HVINGLPQPARQKGRPRKRKP----KDIEAFTANIDLNTEYVD-FGRGSHLSSSSRTKRMRTS 373
            . ...||:  ...|||||||||.    .|:.|:.|.:..|....| ..|.|..|||.:|||||||
Zfish   230 GLSYYNGV--NTVQKGRPRKRKSPGPGADLAAYNAALSCNENDGDPMDRDSQYSSSQKTKRMRTS 292

  Fly   374 FKHHQLRTMKSYFAINHNPDAKDLKQLSQKTGLPKRVLQVWFQNARAKWRRMMMKQDGSGLLEKG 438
            |||||||||||||||||||||||||||:|||||.||||||||||||||:||.:::|:.:|:.:..
Zfish   293 FKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKAS 357

  Fly   439 EGALDLDSISVHSPTSFILG---GPNSTP 464
            :|: :|...:...|.|.|..   .|:|||
Zfish   358 DGS-NLAGGTPSGPASEISNASMSPSSTP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ap	NP_724428.1	LIM1_Lhx2_Lhx9	148..201	CDD:188755	29/52 (56%)
		LIM2_Lhx2_Lhx9	206..264	CDD:188763	31/57 (54%)
		Homeobox	371..424	CDD:395001	49/52 (94%)
lhx2b	NP_001035099.3	LIM1_Lhx2	74..137	CDD:188853	32/71 (45%)
		LIM2_Lhx2_Lhx9	142..200	CDD:188763	31/57 (54%)
		COG5576	<267..389	CDD:227863	73/120 (61%)
		Homeobox	290..342	CDD:278475	49/51 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6033
eggNOG	1	0.900	-	-		E33208_3BD2S
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55848
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174930at2759
OrthoFinder	1	1.000	-	-		FOG0002416
OrthoInspector	1	1.000	-	-		otm25706
orthoMCL	1	0.900	-	-		OOG6_105440
Panther	1	1.100	-	-	O	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3033
SonicParanoid	1	1.000	-	-		X1607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860