DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ap and LHX9

DIOPT Version :9

Sequence 1:	NP_724428.1	Gene:	ap / 35509	FlyBaseID:	FBgn0267978	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_011508083.2	Gene:	LHX9 / 56956	HGNCID:	14222	Length:	403	Species:	Homo sapiens

Alignment Length:	376	Identity:	160/376 - (42%)
Similarity:	212/376 - (56%)	Gaps:	73/376 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RSRTDCTEVSDETTSGISFKTEPFG-PPSSPESTSDSKITRNLDDCSGCGRQIQDRFYLSAVEKR 167
            ||:|:.     ....|........| ||.|||..:         .|:|||.:|.||:||.||:|:
Human    46 RSKTEA-----RLAKGAQLNGRDAGMPPLSPEKPA---------LCAGCGGKISDRYYLLAVDKQ 96

  Fly   168 WHASCLQCYACRQPLERESSCYSRDGNIYCKNDYYSFFGTRRCSRCLASISSNELVMRARNLVFH 232
            ||..||:|..|:..||.|.:|:::||:||||.|||..|..:||:||...||::|:|||||:.|:|
Human    97 WHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYH 161

  Fly   233 VNCFCCTVCHTPLTKGDQYGIIDALIYCRTHYSIAREGDTASSSMSATYPYSAQFGSPHNDSSSP 297
            ::||.|:.|:..||.||.:|:.|:|:|||.|:....:|:         ||....:......|.
Human   162 LSCFTCSTCNKTLTTGDHFGMKDSLVYCRAHFETLLQGE---------YPPQLSYTELAAKSG-- 215

  Fly   298 HSDPSRSIVPTGIFVPASHVINGLPQPARQKGRPRKRKPKDIEAFTANIDLNTEYVDFGRG---- 358
                       |:.:|   ..||  ....|||||||||         :..|..:.|::..|
Human   216 -----------GLALP---YFNG--TGTVQKGRPRKRK---------SPALGVDIVNYNSGCNEN 255

  Fly   359 --SHLS-------SSSRTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLSQKTGLPKRVLQVW 414
              .||.       .|.:||||||||||||||||||||||||||||||||||:|||||.|||||||
Human   256 EADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVW 320

  Fly   415 FQNARAKWRRMMMKQDGSGLLEKGEGALDLDSISVHSPTSFILGGPNSTPP 465
            |||||||:||.:::|:..| ::|.:|.      |:.:|.|...|.  .|||
Human   321 FQNARAKFRRNLLRQENGG-VDKADGT------SLPAPPSADSGA--LTPP 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ap	NP_724428.1	LIM1_Lhx2_Lhx9	148..201	CDD:188755	28/52 (54%)
		LIM2_Lhx2_Lhx9	206..264	CDD:188763	28/57 (49%)
		Homeobox	371..424	CDD:395001	49/52 (94%)
LHX9	XP_011508083.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6077
eggNOG	1	0.900	-	-		E33208_3BD2S
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2768
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174930at2759
OrthoFinder	1	1.000	-	-		FOG0002416
OrthoInspector	1	1.000	-	-		otm40827
orthoMCL	1	0.900	-	-		OOG6_105440
Panther	1	1.100	-	-	LDO	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3033
SonicParanoid	1	1.000	-	-		X1607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860