DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ap and lhx9

DIOPT Version :9

Sequence 1:	NP_724428.1	Gene:	ap / 35509	FlyBaseID:	FBgn0267978	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001032320.2	Gene:	lhx9 / 550405	ZFINID:	ZDB-GENE-050417-210	Length:	396	Species:	Danio rerio

Alignment Length:	342	Identity:	153/342 - (44%)
Similarity:	206/342 - (60%)	Gaps:	52/342 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PPSSPESTSDSKITRNLDDCSGCGRQIQDRFYLSAVEKRWHASCLQCYACRQPLERESSCYSRDG 193
            |..|||..:         .|:|||.:|.||:||.||:|:||..||:|..|:..||.|.:|:::||
Zfish    61 PSMSPEKPA---------LCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDG 116

  Fly   194 NIYCKNDYYSFFGTRRCSRCLASISSNELVMRARNLVFHVNCFCCTVCHTPLTKGDQYGIIDALI 258
            :||||.|||..|..:||:||...||::|:|||||:.|:|::||.||.|:..||.||.:|:.|.|:
Zfish   117 SIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCTTCNKTLTTGDHFGMKDNLV 181

  Fly   259 YCRTHYSIAREGDTASSSMSATYPYSAQFGSPHNDSSSPHSDPSRSIVPTGIFVPASHVINGLPQ 323
            |||.|:....:|:   ......|...|..|.                   |:.:|   ..||  .
Zfish   182 YCRVHFETLIQGE---YHPQLNYAELAAKGG-------------------GLALP---YFNG--T 219

  Fly   324 PARQKGRPRKRKPK----DIEAFTANIDLN-TEYVDFGRGSHLSSSSRTKRMRTSFKHHQLRTMK 383
            ...|||||||||..    ||.::::..:.| .:::|..:..: ..|.:|||||||||||||||||
Zfish   220 GTVQKGRPRKRKSPAMGIDIGSYSSGCNENDADHLDRDQQPY-PPSQKTKRMRTSFKHHQLRTMK 283

  Fly   384 SYFAINHNPDAKDLKQLSQKTGLPKRVLQVWFQNARAKWRRMMMKQDGSGLLEKGEGALDLDSIS 448
            |||||||||||||||||:|||||.||||||||||||||:||.:::|:..| ::|.:|.      |
Zfish   284 SYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNVLRQENGG-VDKADGT------S 341

  Fly   449 VHSPTSFILGGPNSTPP 465
            :..|:|   .....|||
Zfish   342 LPPPSS---DSGALTPP 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ap	NP_724428.1	LIM1_Lhx2_Lhx9	148..201	CDD:188755	28/52 (54%)
		LIM2_Lhx2_Lhx9	206..264	CDD:188763	29/57 (51%)
		Homeobox	371..424	CDD:395001	49/52 (94%)
lhx9	NP_001032320.2	LIM1_Lhx2	61..124	CDD:188853	32/71 (45%)
		LIM2_Lhx2_Lhx9	129..187	CDD:188763	29/57 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..272		7/24 (29%)
		Homeobox	271..323	CDD:278475	49/51 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..365		10/38 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6033
eggNOG	1	0.900	-	-		E33208_3BD2S
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174930at2759
OrthoFinder	1	1.000	-	-		FOG0002416
OrthoInspector	1	1.000	-	-		otm25706
orthoMCL	1	0.900	-	-		OOG6_105440
Panther	1	1.100	-	-	LDO	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3033
SonicParanoid	1	1.000	-	-		X1607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860