Protein Alignment ap and lhx8

DIOPT Version :10

• Sequence 1: NP_724428.1
• Gene: ap / 35509
• FlyBaseID: FBgn0267978
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: XP_012816489.1
• Gene: lhx8 / 548653
• XenbaseID: XB-GENE-494997
• Length: 385
• Species: Xenopus tropicalis
• Alignment Length: 494
• Identity: 128/494 - (25%)
• Similarity: 186/494 - (37%)
• Gaps: 166/494 - (33%)

  Fly    13 WQQSARFLGPGAREKSPTP----------PVAHQGSNQCGSAAGANNNHPLFRACSSSSCPDICD 67
            ||.      ||..:..|||          ..|...|.:||.||
 Frog    13 WQP------PGLGQGVPTPRSVRSFLSVLQFAPLMSEECGGAA---------------------- 49

  Fly    68 HSTKPFGNAYGTESFRSYETADRATFEDSAAKFSISRSRTDCTEVSDETTSGISFKTEPFGP--P 130
               .|.|.:..:|......:...|..|||            |:.|             |..|  .
 Frog    50 ---LPMGRSRKSEGTPVQGSPGAAMDEDS------------CSSV-------------PLSPVSS 86

  Fly   131 SSPESTSDSKITRNLDDCSGCGRQIQDRFYLSAVEKRWHASCLQCYACRQPLERESSCYSRDGNI 195
            |||.|...:.:.:....||.||.:|.|::.|...:..||..||.|..||..|.|.:|||.:|.:|
 Frog    87 SSPHSMPAAGLNQGKSVCSNCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDI 151

  Fly   196 YCKNDYYSFFGTRRCSRCLASISSNELVMRARNLVFHVNCFCCTVCHTPLTKGDQYGIIDALIYC 260
            |||.||:..:|| |||||...|.:.:.|.||:..|:|:.||.|..|...|:.|:::.:::..:.|
 Frog   152 YCKLDYFRRYGT-RCSRCGRHIHATDWVRRAKGNVYHLACFACYSCKRQLSTGEEFALVEEKVLC 215

  Fly   261 RTHYSIAREGDTASSSMSATYPYSAQFGSPHNDSSSPHSDPSRSIVPTGIFVPASHVINGLPQPA 325
            |.||..                                                  :::.|.:..
 Frog   216 RVHYDC--------------------------------------------------MLDNLKRAV 230

  Fly   326 RQKGRPRKRKPKDIE-AFTANIDLNTEYVDFGRGSHLSSSSRTKRMRTSFKHHQLRTMKSYFAIN 389
            ....|      ..:| |.....|:|             .....||.||||...||:.|::.||.:
 Frog   231 ENGNR------VSVEGALLTEQDIN-------------QPKPAKRARTSFTADQLQVMQAQFAQD 276

  Fly   390 HNPDAKDLKQLSQKTGLPKRVLQVWFQNARAKWRRMMMKQDGS--------------GLLEK--- 437
            :||||:.|::||::|||.:||:||||||.||:.::.:.....|              .:||:
 Frog   277 NNPDAQTLQKLSERTGLSRRVIQVWFQNCRARHKKHVSPNHSSTTPVTTVQPSRLSPPMLEEMTY 341

  Fly   438 -------GEGALDLDS-ISVHSPTSFILGG--PNSTPPL 466
                   |.....|.| :..||||:..|..  |:|...|
 Frog   342 SAYVPQDGPMLTALHSYMDAHSPTALGLQSLLPHSMTQL 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ap	NP_724428.1	LIM1_Lhx2_Lhx9	148..201	CDD:188755	24/52 (46%)
		LIM2_Lhx2_Lhx9	206..264	CDD:188763	21/57 (37%)
		Homeodomain	368..424	CDD:459649	31/55 (56%)
lhx8	XP_012816489.1	LIM1_Lhx7_Lhx8	103..158	CDD:188767	25/54 (46%)
		LIM2_Lhx7_Lhx8	165..219	CDD:188769	18/53 (34%)
		Homeodomain	255..311	CDD:459649	31/55 (56%)