DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ap and zfh2

DIOPT Version :9

Sequence 1:	NP_724428.1	Gene:	ap / 35509	FlyBaseID:	FBgn0267978	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_524623.2	Gene:	zfh2 / 43795	FlyBaseID:	FBgn0004607	Length:	3005	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	119/531 - (22%)
Similarity:	186/531 - (35%)	Gaps:	148/531 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PPVAHQGSNQCGSA----AGANNNHPLFRACSSSSCPDICDHSTK-----PFGNAYGT------- 79
            ||:.. |:|..|:|    :..||:.....|.|:|...|  .|.|.     |..:...|
  Fly  1722 PPLVF-GANAAGNAVSGPSALNNSITTSTATSASGLGD--THLTSGVSSIPVDSGKATAVPPQTQ 1783

  Fly    80 -------ESFRSYETADRATFEDSAAK-----FSISRSRTD--CTEVSDETTSGISF-------- 122
                   :...|.:...|....|...|     |.|:.|.::  ..|:|.:....:..
  Fly  1784 LNANANSQQLASNQKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNT 1848

  Fly   123 --------KTEPF---GPPSSP------ESTSDSKITRNLDDCSGC--GRQIQDRFYL------- 161
                    |..|:   .|||:.      |.|..:|:|...|.||..  |........|
  Fly  1849 LFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQAKVTPLNDTCSVAVTGPMTSSTISLPPSGNIN 1913

  Fly   162 -----SAVEK-----RWHASCLQCYAC----RQPLERESSCYSRDGNIYCKNDYYS---FFGTRR 209
                 :|..|     :.:||....::.    ..||.|..|..| .|||   :||..   |||
  Fly  1914 LSSKENATSKVLAAGKANASGPVTFSATVPVSTPLSRPESTNS-SGNI---SDYIGNNIFFG--- 1971

  Fly   210 CSRCLASISSNELVM-----------------RARNLVFHVNCFCCTVCHTPLT-KGDQYGIIDA 256
                  .:.|.|.::                 .|.:..:.      |..|:..: ...|..::|.
  Fly  1972 ------QLGSKEQILPYSLDGQIKSEPQDDMIGATDFAYQ------TKQHSSFSFLKQQQDLVDP 2024

  Fly   257 LIYCRTHYSIAREGDT-------ASSSMSATYPYSAQFGSPHNDSSSPHSD-----PSRSIVPTG 309
            ...|.|:    :..||       |.||:::......|.......|.|..||     ||.:....|
  Fly  2025 PEQCLTN----QNADTAQDQSLLAGSSLASNCQSQQQINIFETKSESGSSDVLSRPPSPNSGAAG 2085

  Fly   310 -IFVPASHVIN-GLPQPARQKGRPRKRK------PKDIEAFTANIDLNTEYVDFGRGSHLSSSSR 366
             ::...:.::| .|.......|.|:|.:      .|::.....:..::|::......|..||||.
  Fly  2086 NVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFEKNVAPMVTSGSVSTQFESNSSNSSSSSSST 2150

  Fly   367 T--KRM-RTSFKHHQLRTMKSYFAINHNPDAKDLKQLSQKTGLPKRVLQVWFQNARAKWRRMMMK 428
            :  ||. ||.|..:|::.::.:|..|..|...||:.||:...|..||:.|||||||.|.|::...
  Fly  2151 SGGKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKLLLLSPRVIVVWFQNARQKQRKIYEN 2215

  Fly   429 QDGSGLLEKGE 439
            |..:.|.|..|
  Fly  2216 QPNNTLFENEE 2226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ap	NP_724428.1	LIM1_Lhx2_Lhx9	148..201	CDD:188755	16/75 (21%)
		LIM2_Lhx2_Lhx9	206..264	CDD:188763	10/75 (13%)
		Homeobox	371..424	CDD:395001	22/52 (42%)
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	616..633	CDD:275368
		C2H2 Zn finger	1515..1542	CDD:275371
		C2H2 Zn finger	1543..1564	CDD:275371
		HOX	1797..1853	CDD:197696	8/55 (15%)
		Homeobox	2158..2210	CDD:278475	22/51 (43%)
		Homeobox	2764..2816	CDD:278475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444980
Domainoid	1	1.000	45	1.000	Domainoid score	I3555
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840