DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ap and Lhx2

DIOPT Version :9

Sequence 1:	NP_724428.1	Gene:	ap / 35509	FlyBaseID:	FBgn0267978	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_006497796.1	Gene:	Lhx2 / 16870	MGIID:	96785	Length:	414	Species:	Mus musculus

Alignment Length:	402	Identity:	172/402 - (42%)
Similarity:	227/402 - (56%)	Gaps:	77/402 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 RATFEDSAAKFSISRSRTDCTEVSDETTSGISFKTEPFGPPSSPESTSDSKITRNLDDCSGCGRQ 154
            ||..|..|...:|.|..|:.|                     .|..:||....     |:|||.:
Mouse    21 RAKSEAPAISSAIDRGDTETT---------------------MPSISSDRAAL-----CAGCGGK 59

  Fly   155 IQDRFYLSAVEKRWHASCLQCYACRQPLERESSCYSRDGNIYCKNDYYS--------FFGTRRCS 211
            |.||:||.||:|:||..||:|..|:..||.|.:|:|:||:||||.||||        .|..:||:
Mouse    60 ISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYSPSLHGPHRRFSVQRCA 124

  Fly   212 RCLASISSNELVMRARNLVFHVNCFCCTVCHTPLTKGDQYGIIDALIYCRTHYSIAREG------ 270
            ||...||::|:|||||:||:|:|||.||.|:..||.||.:|:.|:|:|||.|:....:|
Mouse   125 RCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHF 189

  Fly   271 ---DTASSSMSATYPYSAQFGSPHNDSSSPHSDPSRSIVPTGIFVPASHVINGLPQPARQKGRPR 332
               |.|:::.:|....||..||.   .::|...|..:.|.|                 .||||||
Mouse   190 NHADVAAAAAAAAAAKSAGLGSA---GANPLGLPYYNGVGT-----------------VQKGRPR 234

  Fly   333 KRKP----KDIEAFTANIDLN---TEYVDFGRGSHLSSSSRTKRMRTSFKHHQLRTMKSYFAINH 390
            |||.    .|:.|:.|.:..|   .|::|  |.....||.:||||||||||||||||||||||||
Mouse   235 KRKSPGPGADLAAYNAALSCNENDAEHLD--RDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINH 297

  Fly   391 NPDAKDLKQLSQKTGLPKRVLQVWFQNARAKWRRMMMKQDGSGLLEKGEGALDLDSISVHSPTSF 455
            ||||||||||:|||||.||||||||||||||:||.:::|:.:|:.:..:..|...:.|  .|.|.
Mouse   298 NPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKTSDATLQTGTPS--GPASE 360

  Fly   456 ILG---GPNSTP 464
            :..   .|:|||
Mouse   361 LSNASLSPSSTP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ap	NP_724428.1	LIM1_Lhx2_Lhx9	148..201	CDD:188755	29/52 (56%)
		LIM2_Lhx2_Lhx9	206..264	CDD:188763	31/57 (54%)
		Homeobox	371..424	CDD:395001	49/52 (94%)
Lhx2	XP_006497796.1	LIM1_Lhx2	43..106	CDD:188853	32/67 (48%)
		LIM2_Lhx2_Lhx9	119..177	CDD:188763	31/57 (54%)
		COG5576	<255..386	CDD:227863	71/122 (58%)
		Homeobox	278..331	CDD:395001	49/52 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6058
eggNOG	1	0.900	-	-		E33208_3BD2S
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55848
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2745
Isobase	1	0.950	-	0	Normalized mean entropy	S3827
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174930at2759
OrthoFinder	1	1.000	-	-		FOG0002416
OrthoInspector	1	1.000	-	-		otm42902
orthoMCL	1	0.900	-	-		OOG6_105440
Panther	1	1.100	-	-	O	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3033
SonicParanoid	1	1.000	-	-		X1607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810