Protein Alignment Not3 and NOT3

DIOPT Version :10

• Sequence 1: NP_610176.1
• Gene: Not3 / 35501
• FlyBaseID: FBgn0033029
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_012226.3
• Gene: NOT3 / 854773
• SGDID: S000001300
• Length: 836
• Species: Saccharomyces cerevisiae
• Alignment Length: 898
• Identity: 228/898 - (25%)
• Similarity: 385/898 - (42%)
• Gaps: 175/898 - (19%)

  Fly     3 ATRKLQGEIDRCLKKVAEGVETFEDIWKKVHNATNTNQKQKHLQEKYEADLKKEIKKLQRLRDQI 67
            |.||||.|:||..||:.||:|.|...:::..:.|| |..||   :|.|:|||:|:|||||||:||
Yeast     2 AHRKLQQEVDRVFKKINEGLEIFNSYYERHESCTN-NPSQK---DKLESDLKREVKKLQRLREQI 62

  Fly    68 KSWIASAEIKDKSSLLENRRLIETQMERFKVVERETKTKAYSKEGLGAAQKMDPAQRIKDDARNW 132
            |||.:|.:||||.|||:.||.:|..||::|.||:.:|.||||...|..::.:||.:|.:.|...:
Yeast    63 KSWQSSPDIKDKDSLLDYRRSVEIAMEKYKAVEKASKEKAYSNISLKKSETLDPQERERRDISEY 127

  Fly   133 LTSSISSLQIQIDQYESEIESLLA--GKKKRLDRDKQERMDDLRGKLDRHKFHITKLETLLRLLD 195
            |:..|..|:.|.|..:.||:.||.  .|||.......|:.:..:....|:::|..::|..||||.
Yeast   128 LSQMIDELERQYDSLQVEIDKLLLLNKKKKTSSTTNDEKKEQYKRFQARYRWHQQQMELALRLLA 192

  Fly   196 NDGVEAEQVNKIKDDVEYYIDSSQEPDFEENEFIYD-------DIIGLDEVELSGTATTDSNNSN 253
            |:.::.:.|..::||:.|:::|:|:|||.|:|.|||       :.|..:..:...:...:.||::
Yeast   193 NEELDPQDVKNVQDDINYFVESNQDPDFVEDETIYDGLNLQSNEAIAHEVAQYFASQNAEDNNTS 257

  Fly   254 ETSGSPSSVTSGGSPSQSPVTVQQILNTSSQGAASSGSSAASAALFQQQLTAAQSNGNNVGYASD 318
            :.:.|                :|.|...|.:........|..||    :|.|..:.|..:..|..
Yeast   258 DANES----------------LQDISKLSKKEQRKLEREAKKAA----KLAAKNATGAAIPVAGP 302

  Fly   319 TS-------AASSSATTSTDPAGGTVAVNCVGGLADKRN-KSSESNALKLKPQPHQLIKPTPVRA 375
            :|       .|.:|..|...|:...:........|.|.: ||..|:|..|.|.    ::.:|..|
Yeast   303 SSTPSPVIPVADASKETERSPSSSPIHNATKPEEAVKTSIKSPRSSADNLLPS----LQKSPSSA 363

  Fly   376 TAKLPLSSDTQV----NKIVSST-------PSKNQQQLPTAASIVATSAMQSQSSIGSCSS---- 425
            |.:.|.:..|.:    |.|..:|       |:|...:|..|  :.|:.|::....:.|.||
Yeast   364 TPETPTNVHTHIHQTPNGITGATTLKPATLPAKPAGELKWA--VAASQAVEKDRKVTSASSTISN 426

  Fly   426 ----TGGTGASQSASSGNNPG-----NNPAVQPNAPT--PGQSGIAAAAASTNVVSATIVSSANV 479
                |..|.|:.:.||..|..     |.|.:..::.:  |..:|.:::||:...|.|...::.:.
Yeast   427 TSTKTPTTAAATTTSSNANSRIGSALNTPKLSTSSLSLQPDNTGASSSAATAAAVLAAGAAAVHQ 491

  Fly   480 QGQSVIQ-------PTPTIAFAAVAKHN--TSLLENGP------VLQQQLAVTPTVAAIVGAGTQ 529
            ..|:..:       |..::|....::|.  |::.:|||      |::|:
Yeast   492 NNQAFYRNMSSSHHPLVSLATNPKSEHEVATTVNQNGPENTTKKVMEQK---------------- 540

  Fly   530 AQQKHVPPLSNLQTNSPHIQNGLPVSDSTNDNSCNVVDTISLKTMAQDAINRSAIDPNSLNQQQT 594
                        :..||..:|.|.|.      :..|.|.                |..|....:|
Yeast   541 ------------EEESPEERNKLQVP------TFGVFDD----------------DFESDRDSET 571

  Fly   595 SSIDLRQPQSQKSL-LQHFNSETNTNQQQLTSQQQQQLQNNSLAATTGSNNGTSTGSGLMNVANA 658
            ...:..||.:.|.| |:...::||..:::..|..:..|..:.:.....|       |.|.|  :.
Yeast   572 EPEEEEQPSTPKYLSLEQREAKTNEIKKEFVSDFETLLLPSGVQEFIMS-------SELYN--SQ 627

  Fly   659 TGQPISGNAKTHACQPQQMATTEAHIPTLLGVTPLGPTPLQK-EHQMQFQMMEAAYYHLPQPMDT 722
            ....|:.......|:..::    ..:|.  ||.|  |:||.. ....|:.:|..:.
Yeast   628 IESKITYKRSRDMCEISRL----VEVPQ--GVNP--PSPLDAFRSTQQWDVMRCSL--------- 675

  Fly   723 EKLQTYFHRAPVLTPSHYPQAQMPIYDTV-EFYQRLSTETLFFVFYYMEGSKAQYLAAKALKKQS 786
                    |..::......:....||..: |.::.|...:||:.:|:......:.:|.|.|.::.
Yeast   676 --------RDIIIGSERLKEDSSSIYAKILENFRTLEMFSLFYNYYFAITPLEREIAYKILNERD 732

  Fly   787 WRFHTKYMMWFQRHEEPKIINDDYEQGTYIYFDYEKWSQRKKEGFTFEYKYLE 839
            |:......|||.|..|.|..|:..|.|.|..|..:.|:...|..|..:|.:|:
Yeast   733 WKVSKDGTMWFLRQGEVKFFNEICEVGDYKIFKLDDWTVIDKINFRLDYSFLQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Not3	NP_610176.1	Not3	3..233	CDD:461155	98/238 (41%)
		PRK07764	<334..497	CDD:236090	42/196 (21%)
		NOT2_3_5	711..836	CDD:461199	26/125 (21%)
NOT3	NP_012226.3	Not3	2..230	CDD:461155	98/231 (42%)
		PHA03247	<293..399	CDD:223021	25/109 (23%)
		NOT2_3_5	<695..782	CDD:461199	23/86 (27%)