DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Not3 and AT5G18230

DIOPT Version :9

Sequence 1:	NP_001260712.1	Gene:	Not3 / 35501	FlyBaseID:	FBgn0033029	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001330084.1	Gene:	AT5G18230 / 831941	AraportID:	AT5G18230	Length:	866	Species:	Arabidopsis thaliana

Alignment Length:	962	Identity:	319/962 - (33%)
Similarity:	465/962 - (48%)	Gaps:	220/962 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAATRKLQGEIDRCLKKVAEGVETFEDIWKKVHNATNTNQKQKHLQEKYEADLKKEIKKLQRLRD 65
            |.|:|||||||||.||||.|||:.|:.||.||::..|.|||     ||:|||||||||||||.||
plant     1 MGASRKLQGEIDRVLKKVQEGVDVFDSIWNKVYDTDNVNQK-----EKFEADLKKEIKKLQRYRD 60

  Fly    66 QIKSWIASAEIKDK-------SSLLENRRLIETQMERFKVVERETKTKAYSKEGLGAAQKMDPAQ 123
            |||:||.|:|||||       .||::.|:|||.:|||||:.|:||||||:||||||...|.||.:
plant    61 QIKTWIQSSEIKDKKVSASYEQSLVDARKLIEKEMERFKICEKETKTKAFSKEGLGQQPKTDPKE 125

  Fly   124 RIKDDARNWLTSSISSLQIQIDQYESEIESLLAGKKKRLDRDKQERMDDLRGKLDRHKFHITKLE 188
            :.|.:.|:||.:.:|.|:.|||.:|:|:|.|...|.|    .:..|:..|...:.|||.||.|||
plant   126 KAKSETRDWLNNVVSELESQIDSFEAELEGLSVKKGK----TRPPRLTHLETSITRHKDHIIKLE 186

  Fly   189 TLLRLLDNDGVEAEQVNKIKDDVEYYIDSSQEPDFEE--------NEFIYDDIIGLDEVELSGTA 245
            .:|||||||.:..||||.:||.::.|::.:|: ||:|        :....|::.||:::..:|..
plant   187 LILRLLDNDELSPEQVNDVKDFLDDYVERNQD-DFDEFSDVDELYSTLPLDEVEGLEDLVTAGPL 250

  Fly   246 TTDSNNSNETSGSPSSVTSGGSPSQS------PVTV---------------QQI-LNTSSQGAAS 288
                     ..|:|.|:.|..:.|.|      |:|:               |.| |.|..|....
plant   251 ---------VKGTPLSMKSSLAASASQVRVSIPITLLLKIFCLCFFIFALFQSISLPTHHQEKTE 306

  Fly   289 SGSSAASAALFQQQLTAAQSNGNNVGYASDTSA-------------ASSSATTSTDPAGGTVAVN 340
            ..|...|:|....: |....||..:..|..|.|             :::|.|.||.....| ::.
plant   307 DTSLPDSSAEMVPK-TPPPKNGAGLHSAPSTPAGGRPSLNVPAGNVSNTSVTLSTSIPTQT-SIE 369

  Fly   341 CVGGLADKRNKSSESNALKLKPQPHQLIKPTPVRATAKLPLSSDTQVNKIVSSTPSKNQQQLPTA 405
            .:|.|:....|..::..|..: :|...:..||:|...::.:.:..|.::..|..|:...:...|:
plant   370 SMGSLSPVAAKEEDATTLPSR-KPPSSVADTPLRGIGRVGIPNQPQPSQPPSPIPANGSRISATS 433

  Fly   406 ASIVA-TSAMQSQSSIGSCSS-----------TGGTGASQSASSGNNPGNNPAVQPNAPTPGQSG 458
            |:.|| .:.|..:|::...:|           .|..|    .:|.:|||:
plant   434 AAEVAKRNIMGVESNVQPLTSPLSKMVLPPTAKGNDG----TASDSNPGD--------------- 479

  Fly   459 IAAAAASTNVVSATIVSSA-------------NVQGQSVIQPTPTIAFAAVAKHNTSLLENGPVL 510
              .||:.....|.:|||.:             .|:|::.|.|.....|          |:....:
plant   480 --VAASIGRAFSPSIVSGSQWRPGSPFQSQNETVRGRTEIAPDQREKF----------LQRLQQV 532

  Fly   511 QQ---QLAVTPTVAAIVGAGTQAQ---QKHVPPLSNLQTNSPHIQNGLPVSDSTNDNSCNVVDTI 569
            ||   .|...|:::    .|.:.|   |:..|.|....:.|||...|:.|...    ..||:.:.
plant   533 QQGHGNLLGIPSLS----GGNEKQFSSQQQNPLLQQSSSISPHGSLGIGVQAP----GFNVMSSA 589

  Fly   570 SLKTMAQDAINRSAIDPNSLNQ---QQTSSIDLRQPQSQKSLLQHFNSETNTNQQQLTSQQQQQL 631
            ||:..:           |:::|   ||.|..|          :.|..:: :.:||.|........
plant   590 SLQQQS-----------NAMSQQLGQQPSVAD----------VDHVRND-DQSQQNLPDDSASIA 632

  Fly   632 QNNSLAATTGSNNGTSTGSGL-------MNVAN----ATGQPISGNAKTHACQPQQMATTEAHIP 685
            .:.::.:...|.....|.||:       :.|::    :.||||         ||.|.:::
plant   633 ASKAIQSEDDSKVLFDTPSGMPSYMLDPVQVSSGPDFSPGQPI---------QPGQSSSS----- 683

  Fly   686 TLLGV------TPLG----PTPLQKEH-QM-QFQMMEAAYYHLPQPMDTEKLQTYFHRAPVLTPS 738
              |||      :.||    |:.:...| || ..||:|||:|..|||.|:|:.:.|..|.|.:||.
plant   684 --LGVIGRRSNSELGAIGDPSAVGPMHDQMHNLQMLEAAFYKRPQPSDSERPRPYSPRNPAITPQ 746

  Fly   739 HYPQAQMPIYDTVEFYQRL-----STETLFFVFYYMEGSKAQYLAAKALKKQSWRFHTKYMMWFQ 798
            .:||.|.||.:....::||     .|:||||.|||.:.|..||||||.|||||||:|.|:..|||
plant   747 TFPQTQAPIINNPLLWERLGSDAYGTDTLFFAFYYQQNSYQQYLAAKELKKQSWRYHRKFNTWFQ 811

  Fly   799 RHEEPKIINDDYEQGTYIYFDYEK---------WSQRKKEGFTFEYKYLEDK 841
            ||:||||..|:||||.|:|||::.         |.||.|..|||||.||||:
plant   812 RHKEPKIATDEYEQGAYVYFDFQTPKDENQEGGWCQRIKNEFTFEYSYLEDE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Not3	NP_001260712.1	Not3	3..233	CDD:281986	125/244 (51%)
		DUF3682	428..>509	CDD:289231	17/93 (18%)
		NOT2_3_5	711..836	CDD:282064	70/138 (51%)
AT5G18230	NP_001330084.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	233	1.000	Domainoid score	I640
eggNOG	1	0.900	-	-		E1_COG5665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I490
OMA	1	1.010	-	-		QHG53956
OrthoDB	1	1.010	-	-		D1109812at2759
OrthoFinder	1	1.000	-	-		FOG0004227
OrthoInspector	1	1.000	-	-		oto2941
orthoMCL	1	0.900	-	-		OOG6_101346
Panther	1	1.100	-	-	LDO	PTHR23326
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2972
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840