Protein Alignment Not3 and CNOT3

DIOPT Version :10

• Sequence 1: NP_610176.1
• Gene: Not3 / 35501
• FlyBaseID: FBgn0033029
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001427582.1
• Gene: CNOT3 / 4849
• HGNCID: 7879
• Length: 771
• Species: Homo sapiens
• Alignment Length: 920
• Identity: 371/920 - (40%)
• Similarity: 493/920 - (53%)
• Gaps: 227/920 - (24%)

  Fly     1 MAATRKLQGEIDRCLKKVAEGVETFEDIWKKVHNATNTNQKQKHLQEKYEADLKKEIKKLQRLRD 65
            ||..||||||||||||||:||||.|||||:|:|||.|.|||     |||||||||||||||||||
Human     1 MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQK-----EKYEADLKKEIKKLQRLRD 60

  Fly    66 QIKSWIASAEIKDKSSLLENRRLIETQMERFKVVERETKTKAYSKEGLGAAQKMDPAQRIKDDAR 130
            |||:|:||.|||||..|::||:|||||||||||||||||||||||||||.|||:||||:.|::..
Human    61 QIKTWVASNEIKDKRQLIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVG 125

  Fly   131 NWLTSSISSLQIQIDQYESEIESL-LAGKKKRLDRD-KQERMDDLRGKLDRHKFHITKLETLLRL 193
            .|||::|.:|.:|:||:|||:||| :..:||:.|:| ||:|::.|:..:::|::|:..|||:||:
Human   126 QWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDQKQDRIEGLKRHIEKHRYHVRMLETILRM 190

  Fly   194 LDNDGVEAEQVNKIKDDVEYYIDSSQEPDFEENEFIYDDIIGLDEVELSGTATTDSNNS------ 252
            ||||.:..:.:.|||||||||:||||:||||||||:||| :.|:::..:..||:..::|
Human   191 LDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDD-LDLEDIPQALVATSPPSHSHMEDEI 254

  Fly   253 -NETSGSPSSVTSGG--SPSQSPVTVQQILNTSSQGAASSGSSAASAALFQQQLTAAQSNGNNVG 314
             |::|.:|:|.||..  .||.:..|.:...:...:|.::....:.|.|          .||:...
Human   255 FNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPA----------KNGSKPV 309

  Fly   315 YASDTSAASSSATTSTDPAGGTVAVNCVGGLADKRN---KSSESNAL--KLKPQP-HQLIKPTPV 373
            :::  ....|.|...|.|:|...|.:.:........   .::..:||  |..|.| |....|.|.
Human   310 HSN--QHPQSPAVPPTYPSGPPPAASALSTTPGNNGVPAPAAPPSALGPKASPAPSHNSGTPAPY 372

  Fly   374 RATAKLPLSSDTQVNKIVSSTPSKNQQQLPTAASIVATSAMQSQSSIGSCSSTGGTGASQSASS- 437
            ......|          ..|.||..|.:.|:.           |.|.|....:||.|:|.|::|
Human   373 AQAVAPP----------APSGPSTTQPRPPSV-----------QPSGGGGGGSGGGGSSSSSNSS 416

  Fly   438 ---------------------------GNNPGNNPAVQ-------PNAPTPGQSGIAAAAASTNV 468
                                       .::.|||.:.|       |:.|.|..|...:|||.|..
Human   417 AGGGAGKQNGATSYSSVVADSPAEVALSSSGGNNASSQALGPPSGPHNPPPSTSKEPSAAAPTGA 481

  Fly   469 VSATIVSSANVQGQSVIQP-------TPTIAFAAVAKHNTSLLENGPVLQQQLAVTPTVAAIVGA 526
            ......|..|..|.|::.|       :||.:|:. ||...:|| |||   .|.:..|.:
Human   482 GGVAPGSGNNSGGPSLLVPLPVNPPSSPTPSFSD-AKAAGALL-NGP---PQFSTAPEI------ 535

  Fly   527 GTQAQQKHVPPLSNLQTNSPHIQNGLPVSDSTNDNSCNVVDTISLKTMAQDAINRSAI-DPNSLN 590
                  |...|||                              |||:||:.|...|.| ||
Human   536 ------KAPEPLS------------------------------SLKSMAERAAISSGIEDP---- 560

  Fly   591 QQQTSSIDLRQPQSQKSLLQHFNSETNTNQQQLTSQQQQQLQNNSLAATTGSNNGTSTGSGLMNV 655
               ..::.|    :::.::                          |::|              :.
Human   561 ---VPTLHL----TERDII--------------------------LSST--------------SA 578

  Fly   656 ANATGQPISGNAKTHACQPQQMATTEAHIPTLLGVTPLGPTPLQKEHQMQFQMMEAAYYHLPQPM 720
            ..|:.||           |.|:  :|.:||..|||.||||.||.||...|..|.|||::|:|.|.
Human   579 PPASAQP-----------PLQL--SEVNIPLSLGVCPLGPVPLTKEQLYQQAMEEAAWHHMPHPS 630

  Fly   721 DTEKLQTYFHRAPVLTPSHYPQAQMPIYDTVEFYQRLSTETLFFVFYYMEGSKAQYLAAKALKKQ 785
            |:|:::.|..|.|..||.::.|...|..||||||||||||||||:|||:||:|||||||||||||
Human   631 DSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQ 695

  Fly   786 SWRFHTKYMMWFQRHEEPKIINDDYE-----------------QGTYIYFDYEKWSQRKKEGFTF 833
            |||||||||||||||||||.|.|::|                 ||||||||||||.|||||||||
Human   696 SWRFHTKYMMWFQRHEEPKTITDEFEQIPDHLLVHSLTAFSPGQGTYIYFDYEKWGQRKKEGFTF 760

  Fly   834 EYKYLEDKEL 843
            ||:||||::|
Human   761 EYRYLEDRDL 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Not3	NP_610176.1	Not3	3..233	CDD:461155	155/231 (67%)
		PRK07764	<334..497	CDD:236090	45/210 (21%)
		NOT2_3_5	711..836	CDD:461199	92/141 (65%)
CNOT3	NP_001427582.1	None