DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Not3 and Cnot3

DIOPT Version :9

Sequence 1:	NP_001260712.1	Gene:	Not3 / 35501	FlyBaseID:	FBgn0033029	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001100941.2	Gene:	Cnot3 / 308311	RGDID:	1304771	Length:	751	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	376/892 - (42%)
Similarity:	496/892 - (55%)	Gaps:	191/892 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAATRKLQGEIDRCLKKVAEGVETFEDIWKKVHNATNTNQKQKHLQEKYEADLKKEIKKLQRLRD 65
            ||..||||||||||||||:||||.|||||:|:|||.|.|||     |||||||||||||||||||
  Rat     1 MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQK-----EKYEADLKKEIKKLQRLRD 60

  Fly    66 QIKSWIASAEIKDKSSLLENRRLIETQMERFKVVERETKTKAYSKEGLGAAQKMDPAQRIKDDAR 130
            |||:|:||.|||||..|:|||:|||||||||||||||||||||||||||.|||:||||:.|::..
  Rat    61 QIKTWVASNEIKDKRQLIENRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVG 125

  Fly   131 NWLTSSISSLQIQIDQYESEIESL-LAGKKKRLDRDKQERMDDLRGKLDRHKFHITKLETLLRLL 194
            .|||::|.:|.:|:||:|||:||| :..:||:.|:|||:|::.|:..:::|::|:..|||:||:|
  Rat   126 QWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRMLETILRML 190

  Fly   195 DNDGVEAEQVNKIKDDVEYYIDSSQEPDFEENEFIYDDIIGLDEVELSGTATTDSNNS------- 252
            |||.:..:.:.|||||||||:||||:||||||||:||| :.|:::..:..||:..::|
  Rat   191 DNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDD-LDLEDIPQALVATSPPSHSHMEDEIF 254

  Fly   253 NETSGSPSSVTSGG--SPSQSPVTVQQILNTSSQGAASSGSSAASAALFQQQLTAAQSNGNNVGY 315
            |::|.:|:|.||..  .||.:..|.:...:...:|.::....:.|.|          .||:...:
  Rat   255 NQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPA----------KNGSKPVH 309

  Fly   316 ASDTSAASSSATTSTDPAG---GTVAVNCVGGLADKRNKSSESNAL--KLKPQP-HQLIKPTPVR 374
            ::  ....|.|...|.|:|   .|.|::...|.......::..:||  |..|.| |....|.|.
  Rat   310 SN--QHPQSPAVPPTYPSGPPPATSALSSTPGNNGASTPAAPPSALGPKASPAPSHNSGTPAPY- 371

  Fly   375 ATAKLPLSSDTQVNKIVSSTPSKNQQQLPTAASIVATSAMQSQSSIGSCSSTGGTGASQS----- 434
            |.|..|.:         :|.||..|.:.|:|.....:......||..|.|.|||....|:
  Rat   372 AQAVAPPN---------ASGPSNAQPRPPSAQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSY 427

  Fly   435 -------------ASSGNNPGNNPAVQPNA----PTPG---QSGIAAAAASTNVVSATIVSSANV 479
                         :|||.:..::.|:.|.:    |.|.   :|..||.:.:.:|.|.   |..|.
  Rat   428 SSVVADSPAEVALSSSGGSSASSQALGPTSGPHNPAPSTLKESSTAAPSGAGSVASG---SGNNS 489

  Fly   480 QGQSVIQP-------TPTIAFAAVAKHNTSLLENGPVLQQQLAVTPTVAAIVGAGTQAQQKHVPP 537
            .|.|::.|       :||.:|:......|.|  |||   .|.:.||.:            |...|
  Rat   490 GGPSLLVPLPVNPPSSPTPSFSEAKAAGTLL--NGP---PQFSTTPEI------------KAPEP 537

  Fly   538 LSNLQTNSPHIQNGLPVSDSTNDNSCNVVDTISLKTMAQDAINRSAI-DPNSLNQQQTSSIDLRQ 601
            ||                              |||:||:.|...|.| ||       ..::.|
  Rat   538 LS------------------------------SLKSMAERAAISSGIEDP-------VPTLHL-- 563

  Fly   602 PQSQKSLLQHFNSETNTNQQQLTSQQQQQLQNNSLAATTGSNNGTSTGSGLMNVANATGQPISGN 666
                            |::..:.|                |.:...|.|          ||
  Rat   564 ----------------TDRDIILS----------------STSAPPTSS----------QP---- 582

  Fly   667 AKTHACQPQQMATTEAHIPTLLGVTPLGPTPLQKEHQMQFQMMEAAYYHLPQPMDTEKLQTYFHR 731
                   |.|:  :|.:||..|||.||||..|.||...|..|.|||::|:|.|.|:|:::.|..|
  Rat   583 -------PLQL--SEVNIPLSLGVCPLGPVSLTKEQLYQQAMEEAAWHHMPHPSDSERIRQYLPR 638

  Fly   732 APVLTPSHYPQAQMPIYDTVEFYQRLSTETLFFVFYYMEGSKAQYLAAKALKKQSWRFHTKYMMW 796
            .|..||.::.|...|..||||||||||||||||:|||:||:||||||||||||||||||||||||
  Rat   639 NPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMW 703

  Fly   797 FQRHEEPKIINDDYEQGTYIYFDYEKWSQRKKEGFTFEYKYLEDKEL 843
            ||||||||.|.|::|||||||||||||.|||||||||||:||||::|
  Rat   704 FQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDL 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Not3	NP_001260712.1	Not3	3..233	CDD:281986	156/230 (68%)
		DUF3682	428..>509	CDD:289231	26/112 (23%)
		NOT2_3_5	711..836	CDD:282064	92/124 (74%)
Cnot3	NP_001100941.2	Not3	3..229	CDD:397951	157/231 (68%)
Cnot3	NP_001100941.2	COG5665	12..749	CDD:227952	366/878 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339565
Domainoid	1	1.000	331	1.000	Domainoid score	I1114
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1002
OMA	1	1.010	-	-		QHG53956
OrthoDB	1	1.010	-	-		D1109812at2759
OrthoFinder	1	1.000	-	-		FOG0004227
OrthoInspector	1	1.000	-	-		oto96535
orthoMCL	1	0.900	-	-		OOG6_101346
Panther	1	1.100	-	-	LDO	PTHR23326
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2972
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.910