Protein Alignment Not3 and not3

DIOPT Version :9

• Sequence 1: NP_001260712.1
• Gene: Not3 / 35501
• FlyBaseID: FBgn0033029
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_594789.2
• Gene: not3 / 2542126
• PomBaseID: SPAC1B3.05
• Length: 640
• Species: Schizosaccharomyces pombe
• Alignment Length: 854
• Identity: 250/854 - (29%)
• Similarity: 380/854 - (44%)
• Gaps: 233/854 - (27%)

  Fly     3 ATRKLQGEIDRCLKKVAEGVETFEDIWKKVHNATNTNQKQKHLQEKYEADLKKEIKKLQRLRDQI 67
            :.||||.||::..|||.:|:..|:::::|:..:.:.:||     ||.|.|||.:|||||||||||
pombe     2 SARKLQVEIEKTFKKVTDGIAIFDEVYEKLSASNSVSQK-----EKLEGDLKTQIKKLQRLRDQI 61

  Fly    68 KSWIASAEIKDKSSLLENRRLIETQMERFKVVERETKTKAYSKEGLGAAQKMDPAQRIKDDARNW 132
            |:|.:|.:||||.:|||||||||.:||.||.||||.|.||:|||||..|.|:||.::.|.|...|
pombe    62 KTWASSNDIKDKKALLENRRLIEAKMEEFKAVEREMKIKAFSKEGLSIASKLDPKEKEKQDTIQW 126

  Fly   133 LTSSISSLQIQIDQYESEIESLLA----GKKKRLDRDKQERMDDLRGKLDRHKFHITKLETLLRL 193
            :::::..|:.|.:..|:|.|||.|    |||   |..|...:.:|..:::|||:|..|||.::|.
pombe   127 ISNAVEELERQAELIEAEAESLKATFKRGKK---DLSKLSHLSELESRIERHKWHQDKLELIMRR 188

  Fly   194 LDNDGVEAEQVNKIKDDVEYYIDSSQEPDFEENEFIYDDIIGLDEVELSGTATTDSNNSNETSGS 258
            |:|..:..|.||.|::|:.||::.||..||.|:|.:||: :.|||...|..|        |.||.
pombe   189 LENSQISPEAVNDIQEDIMYYVECSQSEDFAEDENLYDE-LNLDEASASYDA--------ERSGR 244

  Fly   259 PSSVTSGGSPSQSPVTVQQILNTSSQGAASSGSSAASAALFQQQLTAAQSNGNNVGYASDTSAAS 323
            .||.:...|||.|                   ||::|..|.|.:..|.:.      .::|.|...
pombe   245 SSSSSHSPSPSAS-------------------SSSSSENLLQDKAEAEEK------VSADASVQD 284

  Fly   324 SSATTSTDPAGGTVAVNCVGGLADKRNKSSESNALKLKPQPHQLIKPTPVRATAKLPLSSDTQVN 388
            .:...|.| |...:|.|      |:.:...|:.|                          :||.:
pombe   285 IAEKESLD-ADKELATN------DQEDDEEENQA--------------------------ETQKD 316

  Fly   389 KIVSSTPSKNQQQLPTAASIVATSAMQSQSSIGSCSSTGGTGASQSASSGNNPGNNPAVQPNAPT 453
            ..:|:..:                 |||:                             ||...|:
pombe   317 GAISNNEN-----------------MQSE-----------------------------VQTTNPS 335

  Fly   454 PGQSGIAAAAASTNVVSATIVSS----ANVQGQSVIQP-TPTIAFAAVAKHNTSLLENGPVLQQQ 513
                  |:.:|.||:...|::.:    .:|....|..| ||.....|            |.::.:
pombe   336 ------ASTSAVTNITKPTLIQNPSTPLSVSNSKVASPETPNATHTA------------PKVEMR 382

  Fly   514 LAVTPTVAAIVGAGTQAQQKHVPPLSNLQT-NSPHIQNGLPVS--DSTNDNSCNVVDTISLKTMA 575
            .|.....||...|.......::......:| |||.:.:.:..|  ||....:...:.|..:::::
pombe   383 YASAAAAAAAALAKESPSHHYIMQQVRPETPNSPRLNSTVIQSKWDSLGHTASPKMQTQPVRSVS 447

  Fly   576 Q-DAINRSAIDPNSLNQQQTSSIDLRQPQSQKSLLQHFNSETNTNQQQLTSQQQQQLQNNSLAAT 639
            | .|...:.:.|   .:::.:.:.:..|...|.|:...|          ||::|
pombe   448 QSSATTETNVKP---TKEENADVPVSSPDYLKDLVNALN----------TSKEQ----------- 488

  Fly   640 TGSNNGTSTGSGLMNVANATGQPISGNAKTHACQPQQMATTEAHIPTLLGVTPLGPTPLQKEHQM 704
                                          |.....:...|||
pombe   489 ------------------------------HKGAIDKEKLTEA---------------------- 501

  Fly   705 QFQMMEAAYYHLPQPMDTEKLQTYFHRAPVLTPSHYPQAQMPIYDTVEFYQRLSTETLFFVFYYM 769
                :..:..::|...|..|.|.|..:.|...|.:|||..:|::|:.|..:.:..:|||::|||.
pombe   502 ----LNISCVYVPDATDAAKPQYYIPKDPYPVPHYYPQQPLPLFDSSEMTELVDPDTLFYMFYYR 562

  Fly   770 EGSKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKIINDDYEQGTYIYFDYE-KWSQRKKEGFTF 833
            .|:..||:|.:.|||||||||.||..|||||||||:|.|::|.|:|.|||:| .|.||||..|.|
pombe   563 PGTYQQYIAGQELKKQSWRFHKKYTTWFQRHEEPKMITDEFESGSYRYFDFEGDWVQRKKADFRF 627

  Fly   834 EYKYLEDKE 842
            .|:||||.:
pombe   628 TYQYLEDDD 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Not3	NP_001260712.1	Not3	3..233	CDD:281986	109/233 (47%)
		DUF3682	428..>509	CDD:289231	14/85 (16%)
		NOT2_3_5	711..836	CDD:282064	59/125 (47%)
not3	NP_594789.2	Not3	2..228	CDD:281986	109/234 (47%)
		COG5665	12..636	CDD:227952	244/842 (29%)
		NOT2_3_5	505..629	CDD:282064	59/123 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	217	1.000	Domainoid score	I573
eggNOG	1	0.900	-	-		E1_COG5665
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	380	1.000	Inparanoid score	I419
OMA	1	1.010	-	-		QHG53956
OrthoFinder	1	1.000	-	-		FOG0004227
OrthoInspector	1	1.000	-	-		oto100975
orthoMCL	1	0.900	-	-		OOG6_101346
Panther	1	1.100	-	-	LDO	PTHR23326
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R834
SonicParanoid	1	1.000	-	-		X2972
TreeFam	1	0.960	-	-
	13	12.860