DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1344 and scyl1

DIOPT Version :9

Sequence 1:	NP_001260711.1	Gene:	CG1344 / 35500	FlyBaseID:	FBgn0027507	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	XP_001332508.1	Gene:	scyl1 / 793792	ZFINID:	ZDB-GENE-030131-8915	Length:	855	Species:	Danio rerio

Alignment Length:	784	Identity:	177/784 - (22%)
Similarity:	280/784 - (35%)	Gaps:	197/784 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVEENAVETNQFWTVYNAKTPETTNDERCSQMLSVFEGKVFVKAHVWSNGVGPIER------AIK 70
            |:.||. |.:..||:...|...|      .:.:|||         |:....|..|:      |.|
Zfish    17 LLPENQ-EKSGIWTLSRGKRKST------GEPVSVF---------VYEVSQGTEEQTQLAKAAFK 65

  Fly    71 NLMVYRHPYILKYIATWEKSGRKYLATERVRPLDEVLAQQ------TDIEVCLGLRTILCALIFL 129
            .....|||.||.|:...|.....|:.||.|.||...|..|      :|:||..||..|:.||.||
Zfish    66 RTKTLRHPNILSYVDGLETEKSLYIVTEPVTPLAAHLKLQAEKGGASDLEVSWGLHQIVKALSFL 130

  Fly   130 VEKALARHLNINTQSIYVTESGSWRLAGFEYVWRATDVNKQLLDLAHSFI---DLTIH------- 184
            |......|.|:...:::|..:|.|:|.|.::|   |......:.|....:   ||..:
Zfish   131 VNDCHLNHNNLGMWAVFVDRAGEWKLGGLDHV---TSEQGDSITLPPPKVINPDLERYDPPESPN 192

  Fly   185 --GENFEQFFFSILC----------EKVLSRKGTDSCITDSTPHVHEFREYCSTHLKHQNTKLRP 237
              ||.:....:.:.|          .:..|.:..........||      ||  .|...|.|:||
Zfish   193 SGGEKWTGDVWRLGCLIWEVFNGSLPRASSLRSLGKIPKQLVPH------YC--ELVGANPKIRP 249

  Fly   238 RLSAILLH-----PYFNHEFVLIHSFLFELPLKSVHERHKFFRSLIDRLRYFDEEVVASQLACDL 297
            ..:..||:     .:.|:.||....||.|:.:|...|:.:||:.|.:.|..|.|:....::...|
Zfish   250 NPARFLLNCRSPGGFMNNSFVESCLFLEEIQIKEPAEKQQFFQDLSENLDSFPEDFCKHKVLPQL 314

  Fly   298 LSRMVLLDPAAQEF-------VTPHILRTKVTDKAPASLFSPQIYVQYLMPHILKMFRLRDAQIR 355
            |:        |.||       :||..   ||     ....|.:.|.|.::|.|:|||...|..:|
Zfish   315 LT--------AFEFGNAGAVVLTPLF---KV-----GKYLSAEEYQQKIIPVIVKMFSSTDRAMR 363

  Fly   356 LILLDYFMDYVRLLSDEQLESEILPHLQLGMNDTNDVLVGKTLRCM---ADLVSILGANKVLGGD 417
            :.||.....:::.|::..:.|:|.||:..|..|||..:..:|::.|   |..::....|:.|...
Zfish   364 IRLLQQMEQFIQYLNEAAVNSQIFPHVVHGFTDTNPAIREQTVKSMLLLAPKLNETNLNQELMRH 428

  Fly   418 RAR----------------CFSDGRPH-----------AAVSRDSNNPYPEPRSISPL--MNTRS 453
            .||                |.....|:           :|.||.:.:|:|..|:...|  ..|..
Zfish   429 FARLQARDDQGPIRCNTTVCLGKIAPYLNAGMRQRVLISAFSRATKDPFPASRAAGVLGFAATHQ 493

  Fly   454 FDVEDFMVSGSPLPQESNASPLSIRLSPDGGEDEKLRLNSNEKSISIKHNIDPEKDSYISGTEHE 518
            :    :.|:.|    .:...|....|:.|..::.:.:.....||...|.....|..|.::..|.:
Zfish   494 Y----YSVAES----ANRILPTLCTLTVDPDKNVRDQAFKAIKSFLSKLETVSEDPSKLTEIEKD 550

  Fly   519 RVANIDEEG---TWLDWDNTDHLQQGYQVDHAVTDSETNSNSFAREIQTGKSLSPSYRTGKCNLS 580
            ..|.....|   ||..|              |||...:.::...|....|.....:..|.....:
Zfish   551 VTAAGQTGGSAATWAGW--------------AVTGVSSLTSKLIRNAPAGSEAPSAENTSSPQPA 601

  Fly   581 VGVNETISQTEQKVIDDLSELDIKVQTVIQRSEFNEFDFFKDMEPIIEIRTSTCETPEQI----- 640
            .|...|      ...|...|:..:..:.|:....||.....|.:...|....:.|.||::
Zfish   602 AGSVNT------NTADKAEEMKTQTSSGIKSETSNEETGDTDGDRWDEEDWGSLEDPEKVQTDPD 660

  Fly   641 --SSRFAAAAS-------------AVN----------------CNE---------LCADQGWGHD 665
              .|.:::.:|             ||.                .||         ..||:|||:|
Zfish   661 DWQSNWSSVSSTQKKSNVGRKSSEAVKKQSSDWSSGWDADDSWSNEKDADGQGQSSPADEGWGND 725

  Fly   666 EQDD 669
            ..:|
Zfish   726 WDED 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_001260711.1	PKc_like	24..>170	CDD:304357	47/157 (30%)
scyl1	XP_001332508.1	PKc_like	28..293	CDD:304357	75/290 (26%)
		HEAT repeat	311..333	CDD:293787	7/32 (22%)
		HEAT repeat	348..369	CDD:293787	9/20 (45%)
		HEAT repeat	381..414	CDD:293787	10/32 (31%)
		HEAT repeat	424..455	CDD:293787	4/30 (13%)
		HEAT repeat	464..490	CDD:293787	7/25 (28%)
		HEAT repeat	501..530	CDD:293787	4/28 (14%)
		HEAT	504..534	CDD:281045	5/29 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1074965at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820