DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1344 and SCYL3

DIOPT Version :9

Sequence 1:	NP_001260711.1	Gene:	CG1344 / 35500	FlyBaseID:	FBgn0027507	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_851607.2	Gene:	SCYL3 / 57147	HGNCID:	19285	Length:	742	Species:	Homo sapiens

Alignment Length:	799	Identity:	205/799 - (25%)
Similarity:	333/799 - (41%)	Gaps:	181/799 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNEGSKLKGILVEENAVETNQFWTVYNAKTPETTNDERCSQMLSVFEGKVFVKAHVWSNGVGPI 65
            ||:|.|.||...:.|..........||    |....|   .:..|||..|        ......:
Human     1 MGSENSALKSYTLREPPFTLPSGLAVY----PAVLQD---GKFASVFVYK--------RENEDKV 50

  Fly    66 ERAIKNLMVYRHPYILKYIATWEKSGRKYLATERVRPLDEVLAQQTDIEVCLGLRTILCALIFLV 130
            .:|.|:|...|||.:|::::...::...:|.||||:||:..|...:..|||.|:..||.|||||.
Human    51 NKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLH 115

  Fly   131 EKALARHLNINTQSIYVTESGSWRLAGFEYVWRATDVNKQLL---------------DLAHSFID 180
            ::....|.|:...|::|:|.|.|:|.|.|.|.:.:....:.|               :::..|..
Human   116 DRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTT 180

  Fly   181 L-TIHGENFEQFFFSILCEKVLSRKGTDSCITDSTPHVHEFREYCSTHLKHQNTKLRPRLSAILL 244
            | ..||...:.|.|..|.|.:|:......    |...:..|::...:.|.:...|.||.|..:|.
Human   181 LPECHGHARDAFSFGTLVESLLTILNEQV----SADVLSSFQQTLHSTLLNPIPKCRPALCTLLS 241

  Fly   245 HPYFNHEFVLIHSFLFELPLKSVHERHKFFRSLIDRLRYFDEEVVASQLACDLLSRMVLLDPAAQ 309
            |.:|.::|:.:.:||..|.|||..|:.:||:.|:||:....||::||:|...||:::|..:|.|.
Human   242 HDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAV 306

  Fly   310 EFVTPHILRTKVTDKAPAS---LFSPQIYVQYLMPHILKMFRLRDAQIRLILLDYFMDYVRLLSD 371
            :...|::|..| .|.|...   |.||.::...::|.:|::|.:.:..:|::||.:...||...:.
Human   307 KSFLPYLLGPK-KDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQ 370

  Fly   372 EQLESEILPHLQLGMNDTNDVLVGKTLRCMADLVSILGANKVLGGDRARCFSDGRP--------- 427
            |||:..|||.:.||:.||:|.:|..||..:|.|||:||...|:||:|.:.|....|
Human   371 EQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKNTDLS 435

  Fly   428 ------------HAAVSRDSNNPYPE--PR---SISPLMNTRSFDVEDF----MVSGSPLPQESN 471
                        |:.:|....||:..  |:   |.|..:|::.....|:    :.:|.|..|
Human   436 LEDSPMCVVCSHHSQISPILENPFSSIFPKCFFSGSTPINSKKHIQRDYYNTLLQTGDPFSQ--- 497

  Fly   472 ASPLSIRLSPDGGEDEKLRLNSNEKSISIKHNIDPEKDSYISGTEHERVANIDEEGTWLDWDNTD 536
                .|:...:|..|.|   |::|.|           :::.|.::.      .||  |.||...:
Human   498 ----PIKFPINGLSDVK---NTSEDS-----------ENFPSSSKK------SEE--WPDWSEPE 536

  Fly   537 HLQQ---GYQV--DHAVTDSETNSNSFAREIQTGKSLSPSYRTGKCNLSVGVNET--ISQTEQKV 594
            ..:.   ..|:  .....|.::...:...|..:.....||....|.|...|:..|  ::..|||.
Human   537 EPENQTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPVTSGEQKP 601

  Fly   595 IDDL-----------SELDIKVQTVIQR----------------------------SEFN----- 615
            |..|           |.|..|: :::||                            .||.
Human   602 IPALLSLTEESMPWKSSLPQKI-SLVQRGDDADQIEPPKVSSQERPLKVPSELGLGEEFTIQVKK 665

  Fly   616 ------EFDFFKDMEPII----------EIRTSTCETPE------QISSRFAAAASAVNCNELCA 658
                  |.|:|.||.|.|          |:||......:      |.||:||||       |:..
Human   666 KPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSSKFAAA-------EITE 723

  Fly   659 D--QGWGHDEQDDKDDIVW 675
            .  :||..:.:.:.:|..|
Human   724 GEAEGWEEEGELNWEDNNW 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_001260711.1	PKc_like	24..>170	CDD:304357	45/145 (31%)
SCYL3	NP_851607.2	PK_SCY1_like	9..247	CDD:270913	67/256 (26%)
		Pkinase	26..245	CDD:278497	64/237 (27%)
		HEAT 1	199..238		9/42 (21%)
		HEAT 2	285..323		13/38 (34%)
		HEAT repeat	294..319	CDD:293787	8/25 (32%)
		HEAT 3	333..370		8/36 (22%)
		HEAT repeat	337..367	CDD:293787	8/29 (28%)
		HEAT 4	372..409		18/36 (50%)
		HEAT repeat	376..402	CDD:293787	11/25 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..544		11/59 (19%)
		Interaction with EZR. /evidence=ECO:0000269\|PubMed:12651155	548..742		41/201 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..598		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..652		0/22 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..742		3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142944
Domainoid	1	1.000	200	1.000	Domainoid score	I3031
eggNOG	1	0.900	-	-		E1_KOG1243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3774
Isobase	1	0.950	-	0	Normalized mean entropy	S7407
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1074965at2759
OrthoFinder	1	1.000	-	-		FOG0008108
OrthoInspector	1	1.000	-	-		oto88411
orthoMCL	1	0.900	-	-		OOG6_107909
Panther	1	1.100	-	-	LDO	PTHR12984
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4842
SonicParanoid	1	1.000	-	-		X6059
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740