DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1344 and scyl1

DIOPT Version :9

Sequence 1:	NP_001260711.1	Gene:	CG1344 / 35500	FlyBaseID:	FBgn0027507	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001016149.1	Gene:	scyl1 / 548903	XenbaseID:	XB-GENE-5843537	Length:	827	Species:	Xenopus tropicalis

Alignment Length:	750	Identity:	168/750 - (22%)
Similarity:	275/750 - (36%)	Gaps:	175/750 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 WTVYNAKTPETTNDERCSQMLSVFEGKVFVKAHVWSNGVGPIERAIKNLMVYRHPYILKYIATWE 88
            |.|...| .:|..|     .:|||..::...|...:...   :.|:|.:...:||.||.|:...|
Frog    27 WGVQKGK-KKTGGD-----AVSVFTYEIRPGAEEQTQAA---KTALKRIKTLKHPNILSYVDGLE 82

  Fly    89 KSGRKYLATERVRPLDEVLAQQTD------IEVCLGLRTILCALIFLVEKALARHLNINTQSIYV 147
            .....|:.||.|.||...:..:||      :|:..||..|:.||.|||......|.|:...:::|
Frog    83 TDKCLYIVTEPVTPLGTYVKLRTDSGGVSELEISWGLHQIVKALSFLVNDGNLIHNNVCMSAVFV 147

  Fly   148 TESGSWRLAGFEYVWRA---------------------TDVNKQLLDLAHSFIDLTIHGENFEQF 191
            ..:|.|:|.|.:|::.|                     ||.:|...:...:  |:...|....:.
Frog   148 DRAGEWKLGGLDYMYTAGAEDTAPLKGIEMEKYNPPEKTDRSKTSKEKWSA--DMWCLGCLIWEV 210

  Fly   192 FFSILCEKVLSR---KGTDSCITDSTPHVHEFREYCSTHLKHQNTKLRPRLSAILLH-----PYF 248
            |...|......|   |...|.:    ||      ||  .|...|.|:||..:..|.:     .:|
Frog   211 FNGPLPRPTALRSLGKIPKSLV----PH------YC--ELVGANPKVRPNPARFLQNCRSPGGFF 263

  Fly   249 NHEFVLIHSFLFELPLKSVHERHKFFRSLIDRLRYFDEEVVASQLACDLLSRMVLLDPAAQEF-- 311
            .:.||..:.||.|:.:|...|:..||..|.:.|..|.|:....::...||:        |.||
Frog   264 CNSFVETNLFLEEIQIKDPAEKQTFFEQLSENLDSFPEDFCRHKILPQLLT--------AFEFGS 320

  Fly   312 ----VTPHILRTKVTDKAPASLFSPQIYVQYLMPHILKMFRLRDAQIRLILLDYFMDYVRLLSDE 372
                |.|.:.:.       ....:...|.|.::|.::|||...|..:|:.||....::::.|::.
Frog   321 AGAVVLPPLFKI-------GKFLNADEYQQKIIPVVVKMFSSTDRAMRIRLLQQMENFIQYLNEP 378

  Fly   373 QLESEILPHLQLGMNDTNDVLVGKTLRCMADLVSILGAN-------KVLGGDRAR---------- 420
            .:.::|.||:..|..|||..:..:|::.|..|...|..|       |.....:||
Frog   379 TVNAQIFPHVVHGFMDTNPAIREQTVKSMLLLAPKLNENNLNMELMKHFARLQARDDQGPIRCNT 443

  Fly   421 --CFSDGRPH-----------AAVSRDSNNPYPEPRSISPL--MNTRSF-DVEDFMVSGSPLP-- 467
              |.....|:           :|.||.:.:|:...|:...|  ..|.:| .:.|  .:|..||
Frog   444 TVCLGKIAPYLNPATRQRVLISAFSRATKDPFSPSRAAGVLGFAATHNFYSLTD--CAGKVLPVL 506

  Fly   468 ------QESNASP---LSIRLSPDGGEDEKLRLNSNEKSISIKHNIDPEKDSYISGTEHERVANI 523
                  .|.|...   .:||...|     ||...|.:.|    ...:.|||.:.:......|
Frog   507 CGVTVDPEKNVREQAFKAIRSFLD-----KLETVSEDPS----QLAELEKDVHTASVSPSVV--- 559

  Fly   524 DEEGTWLDWDNT-------DHLQQGYQVDHAVTDSETNSNSFAREIQTGKSLSPSYRTGKCNLSV 581
               |.|..|..|       ..::.|.....|......::.|.|.| .:....:||........|.
Frog   560 ---GGWAGWAVTGVSSLTSKFIRTGGGAQDAAASEGASAPSTASE-ASKPDTAPSSSAPPAAAST 620

  Fly   582 GVNETISQTEQKVIDD-LSELDIKVQTVIQRSEFN-----------EFDFFKDMEPIIEIRTSTC 634
            .......:.|:...|: |...|.:....::.:|.|           ::...|..|..::..:|..
Frog   621 APTSYEPEEEKGAPDNSLDRWDDEDWGSLEDAEQNRGQTENDDWDTDWGHGKTQEKTVDFSSSRS 685

  Fly   635 ETPEQIS---SRFAAAASAVNCNELCADQGWGHDE 666
            :| :|:|   :|.:|           .|.|||.|:
Frog   686 KT-KQVSPPPNRTSA-----------LDDGWGWDD 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_001260711.1	PKc_like	24..>170	CDD:304357	45/172 (26%)
scyl1	NP_001016149.1	PKc_like	27..290	CDD:389743	72/285 (25%)
		HEAT repeat	271..297	CDD:293787	8/25 (32%)
		HEAT repeat	307..335	CDD:293787	7/42 (17%)
		HEAT repeat	344..370	CDD:293787	8/25 (32%)
		HEAT 1	345..383		9/37 (24%)
		HEAT repeat	381..410	CDD:293787	9/28 (32%)
		HEAT 2	384..422		12/37 (32%)
		HEAT repeat	422..453	CDD:293787	4/30 (13%)
		HEAT repeat	462..488	CDD:293787	6/25 (24%)
		HEAT repeat	499..525	CDD:293787	5/25 (20%)
		HEAT 3	502..540		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..827		26/135 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1074965at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920