Protein Alignment CG1344 and scyl1

DIOPT Version :10

• Sequence 1: NP_610175.2
• Gene: CG1344 / 35500
• FlyBaseID: FBgn0027507
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_001016149.1
• Gene: scyl1 / 548903
• XenbaseID: XB-GENE-5843537
• Length: 827
• Species: Xenopus tropicalis
• Alignment Length: 750
• Identity: 168/750 - (22%)
• Similarity: 275/750 - (36%)
• Gaps: 175/750 - (23%)

  Fly    24 WTVYNAKTPETTNDERCSQMLSVFEGKVFVKAHVWSNGVGPIERAIKNLMVYRHPYILKYIATWE 88
            |.|...| .:|..|     .:|||..::...|...:...   :.|:|.:...:||.||.|:...|
 Frog    27 WGVQKGK-KKTGGD-----AVSVFTYEIRPGAEEQTQAA---KTALKRIKTLKHPNILSYVDGLE 82

  Fly    89 KSGRKYLATERVRPLDEVLAQQTD------IEVCLGLRTILCALIFLVEKALARHLNINTQSIYV 147
            .....|:.||.|.||...:..:||      :|:..||..|:.||.|||......|.|:...:::|
 Frog    83 TDKCLYIVTEPVTPLGTYVKLRTDSGGVSELEISWGLHQIVKALSFLVNDGNLIHNNVCMSAVFV 147

  Fly   148 TESGSWRLAGFEYVWRA---------------------TDVNKQLLDLAHSFIDLTIHGENFEQF 191
            ..:|.|:|.|.:|::.|                     ||.:|...:...:  |:...|....:.
 Frog   148 DRAGEWKLGGLDYMYTAGAEDTAPLKGIEMEKYNPPEKTDRSKTSKEKWSA--DMWCLGCLIWEV 210

  Fly   192 FFSILCEKVLSR---KGTDSCITDSTPHVHEFREYCSTHLKHQNTKLRPRLSAILLH-----PYF 248
            |...|......|   |...|.:    ||      ||  .|...|.|:||..:..|.:     .:|
 Frog   211 FNGPLPRPTALRSLGKIPKSLV----PH------YC--ELVGANPKVRPNPARFLQNCRSPGGFF 263

  Fly   249 NHEFVLIHSFLFELPLKSVHERHKFFRSLIDRLRYFDEEVVASQLACDLLSRMVLLDPAAQEF-- 311
            .:.||..:.||.|:.:|...|:..||..|.:.|..|.|:....::...||:        |.||
 Frog   264 CNSFVETNLFLEEIQIKDPAEKQTFFEQLSENLDSFPEDFCRHKILPQLLT--------AFEFGS 320

  Fly   312 ----VTPHILRTKVTDKAPASLFSPQIYVQYLMPHILKMFRLRDAQIRLILLDYFMDYVRLLSDE 372
                |.|.:.:.       ....:...|.|.::|.::|||...|..:|:.||....::::.|::.
 Frog   321 AGAVVLPPLFKI-------GKFLNADEYQQKIIPVVVKMFSSTDRAMRIRLLQQMENFIQYLNEP 378

  Fly   373 QLESEILPHLQLGMNDTNDVLVGKTLRCMADLVSILGAN-------KVLGGDRAR---------- 420
            .:.::|.||:..|..|||..:..:|::.|..|...|..|       |.....:||
 Frog   379 TVNAQIFPHVVHGFMDTNPAIREQTVKSMLLLAPKLNENNLNMELMKHFARLQARDDQGPIRCNT 443

  Fly   421 --CFSDGRPH-----------AAVSRDSNNPYPEPRSISPL--MNTRSF-DVEDFMVSGSPLP-- 467
              |.....|:           :|.||.:.:|:...|:...|  ..|.:| .:.|  .:|..||
 Frog   444 TVCLGKIAPYLNPATRQRVLISAFSRATKDPFSPSRAAGVLGFAATHNFYSLTD--CAGKVLPVL 506

  Fly   468 ------QESNASP---LSIRLSPDGGEDEKLRLNSNEKSISIKHNIDPEKDSYISGTEHERVANI 523
                  .|.|...   .:||...|     ||...|.:.|    ...:.|||.:.:......|
 Frog   507 CGVTVDPEKNVREQAFKAIRSFLD-----KLETVSEDPS----QLAELEKDVHTASVSPSVV--- 559

  Fly   524 DEEGTWLDWDNT-------DHLQQGYQVDHAVTDSETNSNSFAREIQTGKSLSPSYRTGKCNLSV 581
               |.|..|..|       ..::.|.....|......::.|.|.| .:....:||........|.
 Frog   560 ---GGWAGWAVTGVSSLTSKFIRTGGGAQDAAASEGASAPSTASE-ASKPDTAPSSSAPPAAAST 620

  Fly   582 GVNETISQTEQKVIDD-LSELDIKVQTVIQRSEFN-----------EFDFFKDMEPIIEIRTSTC 634
            .......:.|:...|: |...|.:....::.:|.|           ::...|..|..::..:|..
 Frog   621 APTSYEPEEEKGAPDNSLDRWDDEDWGSLEDAEQNRGQTENDDWDTDWGHGKTQEKTVDFSSSRS 685

  Fly   635 ETPEQIS---SRFAAAASAVNCNELCADQGWGHDE 666
            :| :|:|   :|.:|           .|.|||.|:
 Frog   686 KT-KQVSPPPNRTSA-----------LDDGWGWDD 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_610175.2	Protein Kinases, catalytic domain	24..>170	CDD:473864	45/172 (26%)
scyl1	NP_001016149.1	Protein Kinases, catalytic domain	27..290	CDD:473864	72/285 (25%)
		HEAT repeat	271..297	CDD:293787	8/25 (32%)
		HEAT repeat	307..335	CDD:293787	7/42 (17%)
		HEAT repeat	344..370	CDD:293787	8/25 (32%)
		HEAT 1	345..383		9/37 (24%)
		HEAT repeat	381..410	CDD:293787	9/28 (32%)
		HEAT 2	384..422		12/37 (32%)
		HEAT repeat	422..453	CDD:293787	4/30 (13%)
		HEAT repeat	462..488	CDD:293787	6/25 (24%)
		HEAT repeat	499..525	CDD:293787	5/25 (20%)
		HEAT 3	502..540		10/42 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..827		26/135 (19%)