DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1344 and yata

DIOPT Version :9

Sequence 1:	NP_001260711.1	Gene:	CG1344 / 35500	FlyBaseID:	FBgn0027507	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001263082.1	Gene:	yata / 43508	FlyBaseID:	FBgn0260990	Length:	873	Species:	Drosophila melanogaster

Alignment Length:	737	Identity:	169/737 - (22%)
Similarity:	272/737 - (36%)	Gaps:	159/737 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 WTVYNAKTPETTNDERCSQMLSVFEGKVFVKAHVWSNGVGP------IERAIKNLMVYRHPYILK 82
            ||::.||. :||.:|     :|||         |:....|.      .:.|:|.|...|||.||:
  Fly    30 WTLHKAKR-KTTLEE-----VSVF---------VYDIRSGSDTKCELAKAALKRLKTLRHPSILQ 79

  Fly    83 YIATWEKSGRKYLATERVRPLDEVLAQ------QTDIEVCLGLRTILCALIFLVEKALARHLNIN 141
            |:.:.|.....|:|||.|.||....::      |..:.:..|:..|..||.||......||.|::
  Fly    80 YLDSLETDKMLYVATEAVDPLGTYFSKLGSDNVQKGLYLAWGIFQITRALSFLNNDGNLRHNNVS 144

  Fly   142 TQSIYVTESGSWRLAGFEYVWRATDVNKQLLDLAHSFIDLTIHGENFEQFFFSILCEKVLSRKGT 206
            ..|::|..||.|:|...||| .|.|.|    .:..:.|.:|:      :.:.|.........|..
  Fly   145 AWSVFVNASGEWKLGSLEYV-SAADGN----PMPPAKIPVTL------EVYDSPEKNDPSKLKAA 198

  Fly   207 DSCITD-----------------------STPHVHEFRE--YCSTHLKHQNTKLRPRLSAILLH- 245
            ..|..|                       ...|:.:..:  ||  .|...:...||..:.|:..
  Fly   199 TKCSVDMWGLGCLVWEAFNGVLKQRSNLKDIEHIPKSLQSLYC--ELVGASPSNRPNPADIITRC 261

  Fly   246 ----PYFNHEFVLIHSFLFELPLKSVHERHKFFRSLIDRLRYFDEEVVASQLACDLLSRMVLLDP 306
                .:|.::.|....||.|:.:|...|:::||..|...|..|.:.|...::...|::.....|
  Fly   262 RKPGGFFKNDLVDTLLFLEEIQIKDKAEKNRFFSGLTTHLDNFPDNVCRHKILPQLITAYEYGD- 325

  Fly   307 AAQEFVTPHILRTKVTDKAPASLFSPQIYVQYLMPHILKMFRLRDAQIRLILLDYFMDYVRLLSD 371
            |....:.|.....|:.|:..        |.:.::|.::|:|...|...|..||.....::..|..
  Fly   326 AGSAVLAPMFKLGKLLDEVE--------YQKRIVPCVVKLFASTDRVTRSRLLQQLDLFIAHLQP 382

  Fly   372 EQLESEILPHLQLGMNDTNDVLVGKTLRCMADLVSILGAN----KVL------------GGDRAR 420
            :.:..:|.|.:..|..|||..:..:|::.:..|...|..|    :||            ||.|..
  Fly   383 QVVNDQIFPQVAHGFLDTNATIREQTVKSIIHLAPKLNYNNLNVEVLRHFARLQARDDQGGIRTN 447

  Fly   421 ---CFSDGRPH-----------AAVSRDSNNPYPEPR--SISPLMNTRSFDVEDFM---VSGSPL 466
               |.....||           :|..|...:|:|..|  .:..|..|:.:    |:   |:...|
  Fly   448 TTVCLGKIAPHLHPQVRQRVLVSAFIRAMRDPFPPARVAGVLALAATQQY----FLLSEVANRVL 508

  Fly   467 PQESNASPLSIRLSPDGGEDEKLRLNSNEKSIS------IKHNIDPEKDSYISGTEHERVANI-D 524
            |     |..|:.:.|     ||...:...|:|.      .|.:.||.....:....|....:| :
  Fly   509 P-----SLCSLTVDP-----EKTVRDPAFKTIRGFLGKLEKVSEDPSLRETMEADVHTATPSIGN 563

  Fly   525 EEGTWLDWDNTDHLQQGYQVDHAVTDSETNSNSFAREIQTGKSLSPSYRTGKCNLSVGVNETISQ 589
            ...||..|..|....:.|:       |:::| |..|...||::||.     ..:|....:.::|.
  Fly   564 AAATWAGWAVTAVTAKFYR-------SQSDS-SRPRPPLTGRNLSK-----PASLEQPSSSSLST 615

  Fly   590 TEQKVIDDLSELDIKVQTVIQRSEFNEFDFFKDMEPIIEIRTSTCETPEQISSRFAAAASAVNCN 654
            |...|....|.......|....|::...|:  |.|...|:.||...:....:|....|..|.|..
  Fly   616 TTSSVTSMTSLEHESNDTSASASDYGNNDW--DNENWGEMDTSQDPSSPLAASSNNGALMAANAL 678

  Fly   655 ELCADQGWGHDEQDDKDDIVWG 676
            ....| ||.::|        ||
  Fly   679 SEVRD-GWDNEE--------WG 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_001260711.1	PKc_like	24..>170	CDD:304357	51/157 (32%)
yata	NP_001263082.1	PKc_like	30..294	CDD:304357	71/291 (24%)
		Pkinase	34..257	CDD:278497	61/250 (24%)
		HEAT repeat	313..339	CDD:293787	4/26 (15%)
		HEAT repeat	351..375	CDD:293787	7/23 (30%)
		HEAT repeat	388..417	CDD:293787	8/28 (29%)
		HEAT repeat	427..458	CDD:293787	6/30 (20%)
		HEAT repeat	467..493	CDD:293787	6/25 (24%)
		HEAT repeat	504..530	CDD:293787	8/35 (23%)
		DUF4078	<838..859	CDD:290039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1243
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1074965at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12984
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850