DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1344 and CG1951

DIOPT Version :9

Sequence 1:	NP_001260711.1	Gene:	CG1344 / 35500	FlyBaseID:	FBgn0027507	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_651655.1	Gene:	CG1951 / 43423	FlyBaseID:	FBgn0039623	Length:	835	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	160/783 - (20%)
Similarity:	276/783 - (35%)	Gaps:	207/783 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SKLKGILVEENAVETNQ------------FWTVYNAKTPETTNDERCSQMLSVFEGKVFVKAHV- 57
            |.|.|:|...|.....:            .|.|||.....|      .|.:|||   ||.|..:
  Fly    16 STLSGVLPGNNVTREYEVLEQVCTAGVGLMWKVYNGHKKST------KQEVSVF---VFEKKSLE 71

  Fly    58 -WSNG-----VGPIERAIKNLMVYRHPYILKYIATWEKSGRKYL--ATERVRPL------DEVLA 108
             ||..     :..:.|.::.|...|||::|......|:| |..|  |||.|...      |.|.:
  Fly    72 RWSKDDRETMLETLRRGVQQLTKIRHPHVLTVQHPLEES-RDSLAFATEPVFASLANVVGDNVRS 135

  Fly   109 QQT--DIEVCLGLRTILCALIFLVEKALARHLNINTQSIYVTESGSWRLAGFEYV---------- 161
            ::.  |:|:..||..:...|.||.:.|...|.||:.::|.:.::.||:|.||::.
  Fly   136 EKKLYDVEIRHGLLQLFDGLQFLHQDAKIVHRNISAETIVINKNRSWKLFGFDFCIANQPATDGT 200

  Fly   162 --WRATDVNKQLLDLAHSFIDLT--------IHGENFEQF-----FFSILCEKVLSRKGTDSCIT 211
              |...:....|..||...::.|        ::..:.:.|     .|:|...|.|...|:|
  Fly   201 PHWPFREYTTSLHVLAQPSLEYTAPELALNSVNTPDSDLFSLGVLIFTIYAGKPLKMFGSD---- 261

  Fly   212 DSTPHVHEFREYCS---------------------THLKHQNTKLRPRLSAILLHPYFNHEFVLI 255
                 ...||.|.:                     ..|.|.:..|||:|..:....||....|..
  Fly   262 -----YSSFRRYANDLNQRKYPPMNAVPSELTESLKALLHPSANLRPKLHELKQIAYFQDVGVKT 321

  Fly   256 HSFLFELPLKSVHERHKFFR-------------SLIDRLRYFDEEVVASQLACDLLSRMVLLDPA 307
            .|:|..|......::.||::             :|...|.|..:|.|.|.:.
  Fly   322 LSYLDSLYQWDNLQKSKFYKGLPQIIPTLPHRVNLHSILPYLVKEFVNSPMI------------- 373

  Fly   308 AQEFVTPHILRTKVTDKAPASLFSPQIYVQYLMPHILKMFRLRD-AQIRLILLDYFMDYVRLLSD 371
              .||.|::|..       |.:.|.:.|..:::||:..:|:|.| .||.||.:......::|...
  Fly   374 --PFVLPNVLLI-------AEMSSQREYCDHILPHLKPIFKLTDPIQILLIFMQKMDLLLKLTPA 429

  Fly   372 EQLESEILP----HLQLGMNDTNDVLVG--KTLRCMADLVSILGANKVLGGDRARCFSDGRPHAA 430
            |:::..:||    .|:..|....|:.:.  .|...:.|..::  .|.||...:..|.........
  Fly   430 EEVKQSVLPLLYRSLECDMPQIQDLCLAVLPTFSTLIDYNAM--KNSVLPRIKKLCLQSSNVSVK 492

  Fly   431 VSRDSNNPYPEPRSISPLMNTRSFDVEDFMVSGSPLP---QESNASPLSIR----LSPDGGEDEK 488
            |:.        ..||..|:.    :::.::|....||   |..:..|..|.    :......:.|
  Fly   493 VNC--------LISIGKLLE----NLDKWLVLDEILPFLQQIQSREPAIIMGIIGIYKIAMTNTK 545

  Fly   489 LRLNSNEKS---------ISIKHNIDPEKDSYISGTEHERVANIDEEGTWLDWDNTDHLQQ--GY 542
            |.:..:..:         :|:::.:...:.:.|.....|.:..:::|       ..:.|||  ..
  Fly   546 LGITKDVMAHKCIPYLVPLSVENGLTIAQFNTIISLIKEMMGRVEQE-------QREKLQQLSTI 603

  Fly   543 QVDHAVTDSETNSNSFAREIQTGKSLSP--SYRTGKCNLSVGVNETISQTEQKVIDDLSELDIKV 605
            |.|:...|:   |...|.|:: ..:|||  |....|.|..:....|:.|.:..:...::....:.
  Fly   604 QRDNKPKDA---SEILANELE-NSTLSPYGSINGNKINDDMFSGFTVGQPKAAIGAAIAPAKARE 664

  Fly   606 QTVIQRSEFNEFDFFKDMEPIIEIRTSTCETPEQISSRF-----------AAAASAVNCNELCAD 659
            |..|..:               .|.......|:.:||..           .|||......::.::
  Fly   665 QLKISHN---------------TISAPPAARPDILSSMMQSNLTGLGTITVAAAPPPTTTQMPSN 714

  Fly   660 QGW 662
            .||
  Fly   715 NGW 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_001260711.1	PKc_like	24..>170	CDD:304357	48/174 (28%)
CG1951	NP_651655.1	Pkinase	31..314	CDD:278497	68/301 (23%)
		PK_SCY1_like	37..316	CDD:270913	70/297 (24%)
		HEAT repeat	396..425	CDD:293787	9/28 (32%)
		HEAT repeat	435..465	CDD:293787	6/29 (21%)
		HEAT repeat	474..501	CDD:293787	6/34 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464141
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12984
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940